American Journal of Reproductive Immunology

Volume 72, Issue 5 pp. 435-439

Short Communication

The CD200-tolerance Signaling Molecule Associated with Pregnancy Success is Present In Patients with Early-stage Breast Cancer but Does not Favor Nodal Metastasis

David A. Clark,

Corresponding Author

David A. Clark

Department of Medicine, McMaster University, Health Sciences Center Rm 3H1E, Hamilton, ON, Canada

Department of Molecular Medicine & Pathology, McMaster University, Hamilton, ON, Canada

Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Toronto General Research Institute, Toronto, ON, Canada

Correspondence

David A. Clark

Department of Medicine, McMaster University, Health Sciences Center Rm 3H1E, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.

E-mail: [email protected]

Search for more papers by this author

Sukhbinder Dhesy-Thind,

Sukhbinder Dhesy-Thind

Department of Oncology, McMaster University and Juravinski Cancer Center, Hamilton, ON, Canada

Search for more papers by this author

Peter Ellis,

Peter Ellis

Department of Oncology, McMaster University and Juravinski Cancer Center, Hamilton, ON, Canada

Search for more papers by this author

Jennifer Ramsay,

Jennifer Ramsay

Department of Molecular Medicine & Pathology, McMaster University, Hamilton, ON, Canada

Search for more papers by this author

David A. Clark,

Corresponding Author

David A. Clark

Department of Medicine, McMaster University, Health Sciences Center Rm 3H1E, Hamilton, ON, Canada

Department of Molecular Medicine & Pathology, McMaster University, Hamilton, ON, Canada

Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Toronto General Research Institute, Toronto, ON, Canada

Correspondence

David A. Clark

Department of Medicine, McMaster University, Health Sciences Center Rm 3H1E, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.

E-mail: [email protected]

Search for more papers by this author

Sukhbinder Dhesy-Thind,

Sukhbinder Dhesy-Thind

Department of Oncology, McMaster University and Juravinski Cancer Center, Hamilton, ON, Canada

Search for more papers by this author

Peter Ellis,

Peter Ellis

Department of Oncology, McMaster University and Juravinski Cancer Center, Hamilton, ON, Canada

Search for more papers by this author

Jennifer Ramsay,

Jennifer Ramsay

Department of Molecular Medicine & Pathology, McMaster University, Hamilton, ON, Canada

Search for more papers by this author

First published: 18 July 2014

https://doi.org/10.1111/aji.12297

Citations: 9

Share a link

Email
Wechat
Bluesky

Abstract

Problem

The CD200-tolerance signaling molecule prevents pregnancy failure and is also expressed by a wide variety of malignant tumors. The effect of CD200 mRNA expression on progression of human tumors has been variable.

Method of study

A cross-sectional study was performed to examine the correlation between CD200 protein expression in the primary tumors from postoperative Stage I–IIIA human breast cancer and the likelihood of regional lymph node metastasis.

Results

Fifty-eight percentage of patients had strong CD200⁺ tumor staining (71% of Stage I and 53% Stage II–IIIA). Strong staining was associated with large T2–3 primary tumors compared to T1 tumors (64 versus 50%) and T2–3 N⁺ versus T1 N⁻ tumors (70 versus 63%), but this was not statistically significant. Nodal metastases were not more frequent in patients with strong CD200⁺ staining (57% compared to 58% for weak/negative staining cases), and the metastatic tumor cells in regional lymph nodes were often CD200⁻ when the primary tumor was CD200⁺.

Conclusion

CD200 expression by early-stage human breast cancer cells in primary tumors did not correlate with increased regional lymph node metastasis.

References

1Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bilger M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN: Characterization of the CD200 receptor family in mice and humans and their interaction with CD200. J Immunol 2003; 171: 3034–3046.
10.4049/jimmunol.171.6.3034
CAS PubMed Web of Science® Google Scholar
2Gorczynski RM, Chen Z, Kai Y, Lei J: Evidence for persistent expression of OX-2 as a necessary component of prolonged renal allograft survival following portal vein immunization. Clin Immunol 2000; 97: 69–78.
10.1006/clim.2000.4907
CAS PubMed Web of Science® Google Scholar
3Gorczynski RM, Chen Z, He W, Khatri I, Sun Y, Yu K, Boudakov I: Expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts. J Immunol 2009; 183: 1569–1568.
10.4049/jimmunol.0900200
CAS PubMed Web of Science® Google Scholar
4Gorczynski RM, Chan Z, Khatri I, Yu G: Graft-infiltrating cells expressing a CD200 transgene prolong allogeneic skin graft survival in association with local increases in Foxp3(+) Treg and mast cells. Transpl Immunol 2011; 25: 187–193.
10.1016/j.trim.2011.07.006
CAS PubMed Web of Science® Google Scholar
5Clark DA, Gorczynski RM: Immunological tolerance/acceptance of the semiallogeneic embryo: decidual transforming growth factors and tolerance signaling molecules. In Immunology of Pregnancy 2013, G Chaouat, S Olivier, N Ledee (eds). Bentham eBooks (eISBN:978-1-60805-733-7), 2013, pp 540–558.
10.2174/9781608057337113010026
Google Scholar
6Clark DA, Chaouat G: Regulatory T cells and reproduction: how do they do it? J Reprod Immunol 2012; 96: 1–7.
10.1016/j.jri.2012.07.007
CAS PubMed Web of Science® Google Scholar
7Moreau J, Veyrune JL, Reme T, De Vos J, Klein B: CD200: a putative therapeutic target in cancer. Biochem Biophys Res Commun 2008; 366: 117–122.
10.1016/j.bbrc.2007.11.103
CAS PubMed Web of Science® Google Scholar
8Talebian F: CD200-CD200R interaction in tumor immunity. PhD Thesis, Ohio State University, 2012. http://rave.ohiolink.edu/etc./view?accnum=osu1331913293.
Google Scholar
9Ghebeh H, Barhoush E, Tulbah A, Elkum N, Al_Tweigeri T, Dermime S: FOXP3⁺ and B7-H1⁺/PD-1⁺ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: implications for immunotherapy. BMC Cancer 2008; 8: 57–68.
10.1186/1471-2407-8-57
CAS PubMed Web of Science® Google Scholar
10Podnos A, Clark DA, Erin N, Yu K, Gorczynski RM: Further evidence for a role for human CD200 expression in breast cancer metastases in CD200R1KO mice. Breast Cancer Res Treat 2012; 136: 117–127.
10.1007/s10549-012-2258-3
CAS PubMed Web of Science® Google Scholar
11Clark DA: Cell-surface CD200 may predict efficacy of paternal mononuclear leukocyte immunotherapy in treatment of human recurrent pregnancy loss. Am J Reprod Immunol 2009; 61: 75–84.
10.1111/j.1600-0897.2008.00665.x
PubMed Web of Science® Google Scholar
12Whiteside TL: Regulatory T cell subsets in human cancer: are they regulating for or against progression? Cancer Immunol Immunother 2014; 63: 67–72.
10.1007/s00262-013-1490-y
CAS PubMed Web of Science® Google Scholar
13Whiteside TL: Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumor-derived exosomes). Biochem Soc Trans 2013; 41: 245–251.
10.1042/BST20120265
CAS PubMed Web of Science® Google Scholar
14Kshirsagar SK, Alam SK, Jasti S, Hodes H, Nauser T, Gilliam M, Billstrand C, Hunt JS, Petroff MG: Immunomodulatory molecules are released from the first trimester and term placenta via exosomes. Placenta 2012; 33: 982–990.
10.1016/j.placenta.2012.10.005
CAS PubMed Web of Science® Google Scholar
15Tannetta D, Mackeen M, Kessler B, Sargent L, Redman C: OSo₄₅. Multi-dimensional protein identification technology analysis of syncytiotrophoblast vesicles released from perfused preeclamptic placentas. Pregnancy Hypertens 2012; 2: 201–202.
Google Scholar
16 American Joint Committee on Cancer: Cancer Staging Manual, 7th edn, SB Edge, DR Byrd, CC Compton, AG Fritz, FL Greene, A Trotti (eds). New York, Springer-Verlag, 2010, p 347.
10.1007/978-0-387-88441-7_32
Google Scholar
17Wong KK, Khatri I, Shaha S, Spanner DE, Gorczynski RM: The role of CD200 in immunity to B cell lymphoma. J Leukoc Biol 2010; 88: 361–372.
10.1189/jlb.1009686
CAS PubMed Web of Science® Google Scholar
18Wong KK, Brennerman F, Chesney A, Spaner DE, Gorczynsiki RM: Soluble CD200 is critical to engraft chronic lymphocytic leukemia cells in immunocompromised mice. Cancer Res 2012; 72: 4931–4943.
10.1158/0008-5472.CAN-12-1390
CAS PubMed Web of Science® Google Scholar
19Gorczynski RM, Chen Z, Khatri I, Podnos A, Yu K: Cure of metastatic growth of EMT6 tumor cells in mice following manipulation of CD200:CD200R signaling. Breast Cancer Res Treat 2013; 142: 271–282.
10.1007/s10549-013-2735-3
CAS PubMed Web of Science® Google Scholar
20Mumm JB, Oft M: Cytokine-based transformation of immune surveillance into tumor-promoting inflammation. Oncogene 2008; 27: 5913–5919.
10.1038/onc.2008.275
CAS PubMed Web of Science® Google Scholar
21Schuh JCL: Trials, tribulation, and trends in tumor modeling in mice. Toxicol Pathol 2004; 32(Suppl 1): 53–66.
10.1080/01926230490424770
CAS PubMed Google Scholar
22Scott OCA: Tumor transplantation and tumor immunity: a personal view. Cancer Res 1991; 51: 757–763.
CAS PubMed Web of Science® Google Scholar
23Hewitt HB, Blake ER, Walder AS: A critique of the evidence for active host defence against cancer based on personal studies of 27 murine tumors of spontaneous origin. Br J Cancer 1976; 33: 241–249.
10.1038/bjc.1976.37
PubMed Web of Science® Google Scholar
24Rosenberg SA: Progress in human tumor immunology and immunotherapy. Nature 2001; 411: 380–384.
10.1038/35077246
CAS PubMed Web of Science® Google Scholar
25Humphries C: Honing that killer instinct. Nature 2013; 504: 513–515.
10.1038/504S13a
CAS Google Scholar

Citing Literature

Volume72, Issue5

November 2014

Pages 435-439

The CD200-tolerance Signaling Molecule Associated with Pregnancy Success is Present In Patients with Early-stage Breast Cancer but Does not Favor Nodal Metastasis

Abstract

Problem

Method of study

Results

Conclusion

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

The CD200-tolerance Signaling Molecule Associated with Pregnancy Success is Present In Patients with Early-stage Breast Cancer but Does not Favor Nodal Metastasis

Abstract

Problem

Method of study

Results

Conclusion

References

Citing Literature

References

Related

Information