Invited Review
Radiology and biomarkers in assessing disease activity in Takayasu arteritis
Ying Sun,
Qingrong Huang,
Lindi Jiang,
Ying Sun
Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
Search for more papers by this authorQingrong Huang
Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
Search for more papers by this authorCorresponding Author
Lindi Jiang
Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
Center of Evidence-based Medicine, Fudan University, Shanghai, China
Correspondence: Lindi Jiang, PhD, MD, Department of Rheumatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. Email: [email protected]Search for more papers by this authorYing Sun,
Qingrong Huang,
Lindi Jiang,
Ying Sun
Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
Search for more papers by this authorQingrong Huang
Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
Search for more papers by this authorCorresponding Author
Lindi Jiang
Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
Center of Evidence-based Medicine, Fudan University, Shanghai, China
Correspondence: Lindi Jiang, PhD, MD, Department of Rheumatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. Email: [email protected]Search for more papers by this authorAbstract
Takayasu arteritis (TA) is a rare and chronic large-vessel vasculitis that predominantly affects aorta and its main branches. It occurs mainly in females <40 years. Precise assessment of disease activity is one of the major difficulties in the long-term management of TA. Until now, the accuracy of traditional activity index is still controversial. During these years, due to rapid development of radiological technology and researches of pathogenesis, new measurements and biomarkers have been applied to monitor disease activity for TA. Thus, in this review, we mainly discuss the benefits and limitations of recent developments of radiology and biomarkers for disease activity assessment in TA.
References
- 1Mason JC (2010) Takayasu arteritis–advances in diagnosis and management. Nat Rev Rheumatol 6 (7), 406–15.
- 2Kerr GS, Hallahan CW, Giordano J et al. (1994) Takayasu arteritis. Ann Intern Med 120 (11), 919–29.
- 3Misra R, Danda D, Rajappa SM et al. (2013) Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Rheumatology (Oxford) 52 (10), 1795–801.
- 4Webb M, Chambers A, AL-Nahhas A et al. (2004) The role of 18F-FDG PET in characterising disease activity in Takayasu arteritis. Eur J Nucl Med Mol Imaging 31 (5), 627–34.
- 5Andrews J, Mason JC (2007) Takayasu's arteritis–recent advances in imaging offer promise. Rheumatology (Oxford) 46 (1), 6–15.
- 6Walter MA (2007) [(18)F]fluorodeoxyglucose PET in large vessel vasculitis. Radiol Clin North Am 45 (4), 735–44, viii.
- 7Blockmans DT, Bley Schmidt W (2009) Imaging for large-vessel vasculitis. Curr Opin Rheumatol 21 (1), 19–28.
- 8Kobayashi Y, Ishii K, Oda K et al. (2005) Aortic wall inflammation due to Takayasu arteritis imaged with 18F-FDG PET coregistered with enhanced CT. J Nucl Med 46 (6), 917–22.
- 9Meller J, Strutz F, Siefker U et al. (2003) Early diagnosis and follow-up of aortitis with [(18)F]FDG PET and MRI. Eur J Nucl Med Mol Imaging 30 (5), 730–6.
- 10Lee KH, Cho A, Choi YJ et al. (2012) The role of (18) F-fluorodeoxyglucose-positron emission tomography in the assessment of disease activity in patients with takayasu arteritis. Arthritis Rheum 64 (3), 866–75.
- 11Tezuka D, Haraguchi G, Ishihara T et al. (2012) Role of FDG PET-CT in Takayasu arteritis: sensitive detection of recurrences. JACC Cardiovasc Imaging 5 (4), 422–9.
- 12Alibaz-Oner F, Dede F, Ones T, Turoglu HT, Direskeneli H (2015a) Patients with Takayasu's arteritis having persistent acute-phase response usually have an increased major vessel uptake by 18F-FDG-PET/CT. Mod Rheumatol 25 (5), 752–5.
- 13Alibaz-Oner F, Aydin SX, Direskeneli H (2013) Advances in the diagnosis, assessment and outcome of Takayasu's arteritis. Clin Rheumatol 32 (5), 541–6.
- 14Fuchs M, Briel M, Daikeler T et al. (2012) The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis. Eur J Nucl Med Mol Imaging 39 (2), 344–53.
- 15Lamare F, Hinz R, Gaemperli O et al. (2011) Detection and quantification of large-vessel inflammation with 11C-(R)-PK1195PET/CT. J Nucl Med 52 (1), 33–9.
- 16Jiang L, Li D, Yan F, Dai X, Li Y, Ma L (2012) Evaluation of Takayasu arteritis activity by delayed contrast-enhanced magnetic resonance imaging. Int J Cardiol 155 (2), 262–7.
- 17Li D, Lin J, Yan F (2011) Detecting disease extent and activity of Takayasu arteritis using whole-body magnetic resonance angiography and vessel wall imaging as a 1-stop solution. J Comput Assist Tomogr 35 (4), 468–74.
- 18Choe YH, Han BK, Koh EM, Kim DK, Do YS, Lee WR (2000) Takayasu's arteritis: assessment of disease activity with contrast-enhanced MR imaging. AJR Am J Roentgenol 175 (2), 505–11.
- 19Sun Y, Ma L, Ji Z et al. (2016) Value of whole-body contrast-enhanced magnetic resonance angiography with vessel wall imaging in quantitative assessment of disease activity and follow-up examination in Takayasu's arteritis. Clin Rheumatol 35 (3), 685–93.
- 20Eshet Y, Pauzner R, Goitein O et al. (2011) The limited role of MRI in long-term follow-up of patients with Takayasu's arteritis. Autoimmun Rev 11 (2), 132–6.
- 21Kato Y, Terashima M, Ohigashi H et al. (2015) Vessel wall inflammation of Takayasu Arteritis detected by contrast-enhanced magnetic resonance imaging: association with disease distribution and activity. PLoS ONE 10 (12), e0145855.
- 22Tombetti E, Mason J (2016) Large vessel vasculitis: the search for response biomarkers. Expert Rev Clin Immunol 12 (10), 1011–3.
- 23Papa M, De Cobelli F, Baldissera E et al. (2012) Takayasu arteritis: intravascular contrast medium for MR angiography in the evaluation of disease activity. AJR Am J Roentgenol 198(3), W279–84.
- 24Tombetti E, Colombo B, Di Chio MC et al. (2016) Chromogranin-A production and fragmentation in patients with Takayasu arteritis. Arthritis Res Ther 18, 187.
- 25Tombetti E, Di Chio MC, Sartorelli S et al. (2014) Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis. Arthritis Res Ther 16 (6), 479.
- 26Einspieler I, Thürmel K, Pyka T et al. (2015) Imaging large vessel vasculitis with fully integrated PET/MRI: a pilot study. Eur J Nucl Med Mol Imaging 42 (7), 1012–24.
- 27Yoshida S, Akiba H, Tamakawa M et al. (2001) The spectrum of findings in supra-aortic Takayasu's arteritis as seen on spiral CT angiography and digital subtraction angiography. Cardiovasc Intervent Radiol 24 (2), 117–21.
- 28Park JH (1996) Conventional and CT angiographic diagnosis of Takayasu arteritis. Int J Cardiol 54 (Suppl), S165–71.
- 29Park JH, Chung JW, Im JG et al. (1995) Takayasu arteritis: evaluation of mural changes in the aorta and pulmonary artery with CT angiography. Radiology 196 (1), 89–93.
- 30Kang EJ, Kim SM, Choe YH, Lee GY, Lee KN, Kim DK (2014) Takayasu arteritis: assessment of coronary arterial abnormalities with 128-section dual-source CT angiography of the coronary arteries and aorta. Radiology 270 (1), 74–81.
- 31Soto ME, Meléndez-Ramírez G, Kimura-Hayama E et al. (2011) Coronary CT angiography in Takayasu arteritis. JACC Cardiovasc Imaging 4 (9), 958–66.
- 32Schmidt WA (2007) Technology Insight: the role of color and power Doppler ultrasonography in rheumatology. Nat Clin Pract Rheumatol 3 (1), 35–42; quiz 59.
- 33Schmidt WA (2013) Imaging in vasculitis. Best Pract Res Clin Rheumatol 27 (1), 107–18.
- 34Schmidt WA, Seipelt E, Krause A, Wernicke D (2007) Carotidynia in Takayasu arteritis. J Rheumatol 34 (1), 231–2.
- 35Chaubal N, Dighe M, Shah M (2004) Sonographic and color doppler findings in aortoarteritis (Takayasu arteritis). J Ultrasound Med 23 (7), 937–44.
- 36Fukudome Y, Abe I, Onaka U et al. (1998) Regression of carotid wall thickening after corticosteroid therapy in Takayasu's arteritis evaluated by B-mode ultrasonography: report of 2 cases. J Rheumatol 25 (10), 2029–32.
- 37Schinkel AF, van den Oord SC, van der Steen AF, van Laar JA, Sijbrands EJ (2014) Utility of contrast-enhanced ultrasound for the assessment of the carotid artery wall in patients with Takayasu or giant cell arteritis. Eur Heart J Cardiovasc Imaging 15 (5), 541–6.
- 38Giordana P, Baqué-Juston MC, Jeandel PY et al. (2011) Contrast-enhanced ultrasound of carotid artery wall in Takayasu disease: first evidence of application in diagnosis and monitoring of response to treatment. Circulation 124 (2), 245–7.
- 39Magnoni M, Dagna L, Coli S, Cianflone D, Sabbadini MG, Maseri A (2011) Assessment of Takayasu arteritis activity by carotid contrast-enhanced ultrasound. Circ Cardiovasc Imaging 4 (2), e1–2.
- 40Germano G, Macchioni P, Possemato N et al. (2017) Contrast-enhanced ultrasound of the carotid artery in patients with large vessel vasculitis: correlation with positron emission tomography findings. Arthritis Care Res (Hoboken) 69 (1), 143–9.
- 41Grosse K, Witte T, Moosig F et al. (2014) Association of ferritin antibodies with Takayasu arteritis. Clin Rheumatol 33 (10), 1523–6.
- 42Praprotnik S, Rozman B, Blank M, Shoenfeld Y (2000) Pathogenic role of anti-endothelial cell antibodies in systemic vasculitis. Wien Klin Wochenschr 112 (15–16), 660–4.
- 43Park MC, Park YB, Jung SY, Lee KH, Lee SK (2006a) Anti-endothelial cell antibodies and antiphospholipid antibodies in Takayasu's arteritis: correlations of their titers and isotype distributions with disease activity. Clin Exp Rheumatol 24 (2 Suppl. 41), S10–6.
- 44Tripathy NK, Sinha N, Nityanand S (2003) Anti-annexin V antibodies in Takayasu's arteritis: prevalence and relationship with disease activity. Clin Exp Immunol 134 (2), 360–4.
- 45Dogan S, Piskin O, Solmaz D et al. (2014) Markers of endothelial damage and repair in Takayasu arteritis: are they associated with disease activity? Rheumatol Int 34 (8), 1129–38.
- 46Arraes AE, de Souza AW, Mariz HA et al. (2016) (18)F-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis. Rev Bras Reumatol Engl Ed 56 (4), 299–308.
- 47Alibaz-Oner F, Yentür SP, Saruhan-Direskeneli G, Direskeneli H (2015b) Serum cytokine profiles in Takayasu's arteritis: search for biomarkers. Clin Exp Rheumatol 33(2 Suppl.89), S-32–5.
- 48Park MC, Lee SW, Park YB, Lee SK (2006b) Serum cytokine profiles and their correlations with disease activity in Takayasu's arteritis. Rheumatology (Oxford) 45 (5), 545–8.
- 49Sun Y, Ma L, Yan F et al. (2012) MMP-9 and IL-6 are potential biomarkers for disease activity in Takayasu's arteritis. Int J Cardiol 156 (2), 236–8.
- 50Tripathy NK, Sinha N, Nityanand S (2004) Interleukin-8 in Takayasu's arteritis: plasma levels and relationship with disease activity. Clin Exp Rheumatol 22 (6 Suppl. 36), S27–30.
- 51Arnaud L, Haroche J, Duhaut P, Piette JC, Amoura Z (2009) Pathogenesis of primary large vessel arteritis. Rev Med Interne 30 (7), 578–84.
- 52Kuroda T, Ueno M, Sato H et al. (2006) A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature. Rheumatol Int 27 (1), 103–7.
- 53Harada M, Yoshida H, Mitsuyama K et al. (1998) Aortitis syndrome (Takayasu's arteritis) with cataract and elevated serum level of vascular endothelial growth factor. Scand J Rheumatol 27 (1), 78–9.
- 54Mahajan N, Dhawan V, Malik S, Jain S (2010) Implication of oxidative stress and its correlation with activity of matrix metalloproteinases in patients with Takayasu's arteritis disease. Int J Cardiol 145 (2), 286–8.
- 55Matsuyama A, Sakai N, Ishigami M et al. (2003) Matrix metalloproteinases as novel disease markers in Takayasu arteritis. Circulation 108 (12), 1469–73.
- 56Ishihara T, Haraguchi G, Tezuka D, Kamiishi T, Inagaki H, Isobe M (2013) Diagnosis and assessment of Takayasu arteritis by multiple biomarkers. Circ J 77 (2), 477–83.
- 57Ishihara T, Haraguchi G, Kamiishi T, Tezuka D, Inagaki H, Isobe M (2011) Sensitive assessment of activity of Takayasu's arteritis by pentraxin3, a new biomarker. J Am Coll Cardiol 57 (16), 1712–3.
- 58Dagna L, Salvo F, Tiraboschi M et al. (2011) Pentraxin-3 as a marker of disease activity in Takayasu arteritis. Ann Intern Med 155 (7), 425–33.
- 59da Silva TF, Levy-Neto M, Bonfá E, Pereira RM (2013) High prevalence of metabolic syndrome in Takayasu arteritis: increased cardiovascular risk and lower adiponectin serum levels. J Rheumatol 40 (11), 1897–904.
- 60Yilmaz H, Gerdan V, Kozaci D et al. (2012) Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritis. Arthritis Res Ther 14 (6), R272.
- 61Serra R, Grande R, Buffone G et al. (2014) Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis. J Pharmacol Pharmacother 5 (3), 193–6.
