Invited review
Endoplasmic reticulum stress is activated in acute pancreatitis
Jian Sheng Wu,
Wei Min Li,
Yi Na Chen,
Qian Zhao,
Qin Fen Chen,
Corresponding Author
Jian Sheng Wu
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Correspondence to: Jian Sheng WU, Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang Province 325000, China. Email: [email protected]Search for more papers by this authorWei Min Li
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorYi Na Chen
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorQian Zhao
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorQin Fen Chen
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorJian Sheng Wu,
Wei Min Li,
Yi Na Chen,
Qian Zhao,
Qin Fen Chen,
Corresponding Author
Jian Sheng Wu
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Correspondence to: Jian Sheng WU, Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang Province 325000, China. Email: [email protected]Search for more papers by this authorWei Min Li
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorYi Na Chen
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorQian Zhao
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorQin Fen Chen
Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Search for more papers by this authorConflict of interest: None.
Abstract
Endoplasmic reticulum (ER) is one of the most important cell organelles in the body, regulating protein synthesis, folding and aggregation. Endoplasmic reticulum stress (ERS) is a particular subcellular pathological process involving an imbalance of homeostasis and ER disorder. In the early stage of ERS, cells show a protective unfolded protein response that changes the cellular transcriptional and translational programs to alleviate the process. Therefore, a certain degree of ERS can activate the protective adaptation of cells, whereas sustained severe ERS triggers an apoptotic signal and leads to apoptosis. Acute pancreatitis is a disease caused by trypsin digestion of the pancreas, although the pathogenesis is not completely understood. However, a close association has been suggested between pancreatitis and ERS. This article reviewed relevant research advances and discussed the effect of ERS on the development and progression of acute pancreatitis.
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