ORIGINAL ARTICLE

The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury

Corresponding Author

Ahmed M. Abd El Wahab

[email protected]

orcid.org/0000-0002-9873-0356

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence

Ahmed M. Abd El Wahab, Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura, Egypt.

Email: [email protected]

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Abeer Awadeen,

Abeer Awadeen

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Mostafa M. Mansour,

Mostafa M. Mansour

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Rasha Shemies,

Rasha Shemies

orcid.org/0000-0002-0770-8023

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Ahmed M. Abd El Wahab,

Corresponding Author

Ahmed M. Abd El Wahab

[email protected]

orcid.org/0000-0002-9873-0356

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence

Ahmed M. Abd El Wahab, Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura, Egypt.

Email: [email protected]

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Abeer Awadeen,

Abeer Awadeen

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Search for more papers by this author

Mostafa M. Mansour,

Mostafa M. Mansour

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Search for more papers by this author

Rasha Shemies,

Rasha Shemies

orcid.org/0000-0002-0770-8023

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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First published: 01 October 2022

https://doi.org/10.1111/1744-9987.13936

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Abstract

Background

Acute kidney injury (AKI) frequently affects patients with liver cirrhosis, diagnosed by changes in serum creatinine and urine output. This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis complicated by AKI.

Methods

A total of 81 cirrhotic patients with AKI were included. AKI was diagnosed according to Kidney Disease Improving Global Outcomes criteria. All patients were assessed clinically and biochemically. Baseline serum Cys C and Ang 2 were assessed, and patients were prospectively followed-up to assess patients' and renal survival.

Results

Cys C significantly predicted AKI (p < 0.001). Ang 2 (≤179.7 pg/ml) was an independent predictor of mortality in multivariate analysis. Marked ascites and partial pressure of carbon dioxide ≤ 29 were significant predictors of nonrenal recovery.

Conclusion

Cys C showed validity AKI diagnosis in cirrhotic patients while Ang 2 was an independent predictor of mortality.

CONFLICT OF INTEREST

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Open Research

DATA AVAILABILITY STATEMENT

All data analyzed during this study are included in the article.

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Volume27, Issue3

June 2023

Pages 419-427

The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

References

Information

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The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

References

Related

Information