Rapid Quantitative Analysis of Multiple Explosive Compound Classes on a Single Instrument via Flow-Injection Analysis Tandem Mass Spectrometry†‡
Corresponding Author
Alla Ostrinskaya M.S.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Corresponding author: Alla Ostrinskaya, M.S. E-mail: [email protected]Search for more papers by this authorRoderick R. Kunz Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorMichelle Clark Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorRichard P. Kingsborough Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorTa-Hsuan Ong Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorSandra Deneault
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorCorresponding Author
Alla Ostrinskaya M.S.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Corresponding author: Alla Ostrinskaya, M.S. E-mail: [email protected]Search for more papers by this authorRoderick R. Kunz Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorMichelle Clark Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorRichard P. Kingsborough Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorTa-Hsuan Ong Ph.D.
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorSandra Deneault
Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421
Search for more papers by this authorAbstract
A flow-injection analysis tandem mass spectrometry (FIA MSMS) method was developed for rapid quantitative analysis of 10 different inorganic and organic explosives. Performance is optimized by tailoring the ionization method (APCI/ESI), de-clustering potentials, and collision energies for each specific analyte. In doing so, a single instrument can be used to detect urea nitrate, potassium chlorate, 2,4,6-trinitrotoluene, 2,4,6-trinitrophenylmethylnitramine, triacetone triperoxide, hexamethylene triperoxide diamine, pentaerythritol tetranitrate, 1,3,5-trinitroperhydro-1,3,5-triazine, nitroglycerin, and octohy-dro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine with sensitivities all in the picogram per milliliter range. In conclusion, FIA APCI/ESI MSMS is a fast (<1 min/sample), sensitive (~pg/mL LOQ), and precise (intraday RSD < 10%) method for trace explosive detection that can play an important role in criminal and attributional forensics, counterterrorism, and environmental protection areas, and has the potential to augment or replace several of the existing explosive detection methods.
Supporting Information
| Filename | Description |
|---|---|
| jfo13827-sup-0001-SupInfo.docxWord document, 187.2 KB |
Table S1. FIA APCI/ESI MSMS explosives detection. MRM transitions and optimized MS parameters for secondary MRM transition used to reduce false positive detection. Figure S1. APCI MSMS spectrum of the 0.4 ng of explosives mix showing 2,6-dinitrotoluene and 4,6- dinitrotoluene at m/z of 182, 2-amino-4, 6-dinitrotoluene and 4-amino-2, 6-dinitrotoluene at m/z 197, 1,3, 5-trinitrobenzene at m/z 213, TNT at m/z 227, Tetryl at m/z 242, RDX at m/z 268, PETN at m/z 315, HMX at m/z 342. Figure S2. urea nitrate calibration curve. Error bars represent 1 standard deviation between 42 measurements at each concentration level. Figure S3. potassium chlorate calibration curve. Error bars represent 1 standard deviation between 60 measurements at each concentration level. Figure S4. TATP calibration curve. Error bars represent 1 standard deviation between 36 measurements at each concentration level. Figure S5. HMTD calibration curve. Error bars represent 1 standard deviation between 84 measurements at each concentration level. Figure S6. TNT calibration curve. Error bars represent 1 standard deviation between 66 measurements at each concentration level. Figure S7. RDX calibration curve. Error bars represent 1 standard deviation between 102 measurements at each concentration level. Figure S8. PETN calibration curve. Error bars represent 1 standard deviation between 114 measurements at each concentration level. Figure S9. NG calibration curve. Error bars represent 1 standard deviation between 36 measurements at each concentration level. Figure S10. HMX calibration curve. Error bars represent 1 standard deviation between 54 measurements at each concentration level. Figure S11. Tetryl calibration curve. Error bars represent 1 standard deviation between 48 measurements at each concentration level. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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