Dual Use of Department of Veterans Affairs and Medicare Benefits on High-Risk Opioid Prescriptions in Veterans Aged 65 Years and Older: Insights from the VA Musculoskeletal Disorders Cohort
Corresponding Author
Philip W. Chui M.D.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Internal Medicine, Yale School of Medicine, New Haven, CT
Address correspondence to Philip W. Chui, M.D., Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516; and also Department of Internal Medicine, Yale School of Medicine, New Haven, CT; e-mail: [email protected].Search for more papers by this authorLori A. Bastian M.D., M.P.H.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Internal Medicine, Yale School of Medicine, New Haven, CT
Search for more papers by this authorEric DeRycke M.P.H.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Search for more papers by this authorCynthia A. Brandt M.D., M.P.H.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Emergency Medicine, Yale School of Medicine, New Haven, CT
Search for more papers by this authorWilliam C. Becker M.D.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Internal Medicine, Yale School of Medicine, New Haven, CT
Search for more papers by this authorJoseph L. Goulet Ph.D.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Search for more papers by this authorCorresponding Author
Philip W. Chui M.D.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Internal Medicine, Yale School of Medicine, New Haven, CT
Address correspondence to Philip W. Chui, M.D., Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516; and also Department of Internal Medicine, Yale School of Medicine, New Haven, CT; e-mail: [email protected].Search for more papers by this authorLori A. Bastian M.D., M.P.H.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Internal Medicine, Yale School of Medicine, New Haven, CT
Search for more papers by this authorEric DeRycke M.P.H.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Search for more papers by this authorCynthia A. Brandt M.D., M.P.H.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Emergency Medicine, Yale School of Medicine, New Haven, CT
Search for more papers by this authorWilliam C. Becker M.D.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Department of Internal Medicine, Yale School of Medicine, New Haven, CT
Search for more papers by this authorJoseph L. Goulet Ph.D.
Pain, Research, Informatics, Medical Comorbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT
Search for more papers by this authorAbstract
Objective
To examine the association of dual use of both Veterans Health Administration (VHA) and Medicare benefits with high-risk opioid prescriptions among Veterans aged 65 years and older with a musculoskeletal disorder diagnosis.
Data Sources/Study Setting
Data were obtained from the VA Musculoskeletal Disorder (MSD) cohort and national Medicare claims data from 2008 to 2010.
Study Design
We conducted a retrospective analysis of Veterans enrolled in Medicare to examine the association of dual use with long-term opioid use (>90 days of prescription opioids/year) and overlapping opioid prescriptions. Multivariable logistic regression was performed adjusting for demographic and clinical characteristics.
Data Collection/Extraction Methods
We identified 21,111 Veterans enrolled in Medicare who entered the MSD cohort in 2008 and received an opioid prescription in 2010. We linked VHA data with Medicare claims data to identify opioid prescriptions for these Veterans in 2010.
Principal Findings
As compared to Veterans who used only VHA or Medicare, Veterans with dual use of VHA and Medicare were significantly more likely to be prescribed long-term opioid therapy (OR = 4.61 (95 percent CI 4.05–5.25) and were also found to have higher median number of opioid prescriptions and higher odds of overlapping opioid prescriptions in 1 year. Patients reporting moderate-to-severe pain, non-white-race/ethnicity, and higher scoring on the Charlson comorbidity index had significantly higher odds of long-term opioid prescriptions.
Conclusions
Among Veterans aged 65 years or older, dual use of both VHA and Medicare was associated with higher odds of long-term opioid therapy. Our findings suggest there may be benefit to combining VHA and non-VHA electronic health record data to minimize exposure to high-risk opioid prescribing.
Supporting Information
Filename | Description |
---|---|
hesr13060-sup-0001-AppendixSA1.pdfPDF document, 1.5 MB | Appendix SA1: Author Matrix. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- Ahrnsbrak, R., J. Bose, S. L. Hedden, R. N. Lipari, and E. Park-Lee. 2017. Substance Abuse and Mental Health Services Administration. “ Key substance use and mental health indicators in the United States: Results from the 2016 National Survey on Drug Use and Health (HHS Publication No. SMA 17-5044, NSDUH Series H-52).”Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration [accessed on November 28, 2017]. Available at https://www.samhsa.gov/data/sites/default/files/NSDUH-FFR1-2016/NSDUH-FFR1-2016.pdf
- American Community Survey. 2016. “ American FactFinder.” Suitland, MD: United States Census Bureau [accessed on November 28, 2017]. Available at https://factfinder.census.gov/faces/nav/jsf/pages/index.xhtml
- Ballantyne, J. C., and J. Mao. 2003. “Opioid Therapy for Chronic Pain.” New England Journal of Medicine 349: 1943–53.
- Becker, W. D., B. T. Fenton, C. A. Brant, E. L. Doyle, J. Francis, J. L. Goulet, B. A. Moore, V. Torrise, R. D. Kerns, and P. W. Kreiner. 2017. “Multiple Sources of Prescription Payment and Risky Opioid Therapy among Veterans.” Medical Care 55 (suppl 7): S33–6.
- Bohnert, A. S., M. A. Ilgen, S. Galaea, J. F. McCarthy, and F. C. Blow. 2011. “Accidental Poisoning Mortality among Veterans in the Department of Veterans Affairs Health System.” Medical Care 49 (4): 393–6.
- Boscarino, J. A., M. Rukstalis, S. N. Hoffman, J. J. Han, P. M. Erlich, G. S. Gerhard, and W. F. Stewart. 2010. “Risk Factors for Drug Dependence among Out-Patients on Opioid Therapy in a Large US Health-Care System.” Addiction 105 (10): 1776–82.
- Brennan, P. L., K. K. Schutte, and R. H. Moos. 2005. “Pain and Use of Alcohol to Manage Pain: Prevalence and 3-Year Outcomes among Older Problem and Non-Problem Drinkers.” Addiction 100: 777–86.
- CDC. 2017. “ Wide-Ranging Online Data for Epidemiologic Research (WONDER).” Atlanta, GA: CDC, National Center for Health Statistics [accessed on November 26, 2017]. Available at https://wonder.cdc.gov/
- Deyo, R. A., D. C. Cherkin, and M. A. Ciol. 1992. “Adapting a Clinical Comorbidity Index for Use with ICD-9-CM Administrative Databases.” Journal of Clinical Epidemiology 45 (6): 613–9.
- Dobscha, S. K., B. J. Morasco, A. E. Kovas, D. M. Peters, K. Hart, and B. H. McFarland. 2015. “Short-Term Variability in Outpatient Pain Intensity Scores in a National Sample of Older Veterans with Chronic Pain.” Pain Med 16 (5): 855–65.
- Dorflinger, L., B. Moore, J. Goulet, W. Becker, A. A. Heapy, J. J. Sellinger, and R. D. Kerns. 2014. “A Partnered Approach to Opioid Management, Guideline Concordant Care and the Stepped Care Model of Pain Management.” Journal of General Internal Medicine 29 (Supp 4): 870–6.
- Dowell, D., T. M. Hargerich, and R. Chou. 2016. “CDC Guideline for Prescribing Opioids for Chronic Pain-United States, 2016.” Journal of the American Medical Association 315 (15): 1624–45.
- Dunn, K. M., K. W. Saunders, C. M. Rutter, C. J. Banta-Green, J. O. Merrill, M. D. Sullivan, C. M. Weisner, M. J. Silverberg, C. I. Campbell, B. M. Psaty, and M. Von Korff. 2010. “Opioid Prescriptions for Chronic Pain and Overdose: A Cohort Study.” Annals of Internal Medicine 152 (2): 85–92.
- Edlund, M. J., D. Steffick, T. Hudson, K. M. Harris, and M. Sullivan. 2007. “Risk Factors for Clinically Recognized Opioid Abuse and Dependence among Veterans Using Opioids for Chronic Non-Cancer Pain.” Pain 129 (3): 355–62.
- Edlund, M. J., B. C. Martin, J. E. Russo, A. DeVries, J. B. Braden, and M. D. Sullivan. 2014. “The Role of Opioid Prescription in Incident Opioid Abuse and Dependence among Individuals with Chronic Noncancer Pain: The Role of Opioid Prescription.” Clinical Journal of Pain 305: 57–64.
- Fihn. 2014. “ US Department of Veterans Affairs. 172VA10P2: VHA Corporate Data Warehouse – VA. 79 FR 4377. ” Updated January 27, 2014 [accessed on March 10, 2017].
- Gellad, W. F., X. Zhao, C. T. Thorpe, M. K. Mor, C. B. Good, and M. J. Fine. 2015. “Dual Use of Department of Veterans Affairs and Medicare Benefits and Use of Test Strips in Veterans with type 2 Diabetes Mellitus.” JAMA Internal Medicine 175 (1): 26–34.
- Gellad, W. F., J. M. Thorpe, X. Zhao, C. T. Thorpe, F. E. Sileanu, J. P. Cashy, J. A. Hale, M. K. Mor, T. R. Radomski, L. R. M. Hausmann, J. M. Donohue, A. J. Gordon, K. J. Suda, K. T. Stroupe, J. T. Hanlon, F. E. Cunningham, C. B. Good, and M. J. Fine. 2018. “Impact of Dual Use of Department of Veterans Affairs and Medicare Part D Drug Benefits on Potentially Unsafe Opioid Use.” American Journal of Public Health 108 (2): 248–55.
- Goulet, J. L., R. D. Kerns, M. Bair, W. C. Becker, P. Brennan, D. Burgess, C. M. Carroll, S. Dobscha, M. A. Driscoll, B. T. Fenton, L. Fraenkel, S. G. Haskell, A. A. Heapy, D. M. Higgins, R. A. Hoff, U. Hwang, A. C. Justice, J. D. Piette, P. Sinnott, L. Wandner, J. A. Womack, and C. A. Brandt. 2016. “The Musculoskeletal Diagnosis Cohort: Examining Pain and Pain Care among Veterans.” Pain 157 (8): 1696–703.
- Hooten, W. M., Y. Shi, H. M. Gazelka, and D. O. Warner. 2011. “The Effects of Depression and Smoking on Pain Severity and Opioid Use in Veterans with Chronic Pain.” Pain 152 (1): 223–9.
- Jena, A. B., D. Goldman, L. Weaver, and P. Karaca-Mandic. 2014. “Opioid Prescribing by Multiple Providers in Medicare: Retrospective Observational Study of Insurance Claims.” BMJ 348: g1393.
- Klabunde, C. N., A. L. Potosky, J. M. Legler, and J. L. Warren. 2000. “Development of a Comorbidity Index Using Physician Claims Data.” Journal of Clinical Epidemiology 53 (12): 1258–67.
- Morasco, B. J., and S. K. Dobscha. 2008. “Prescription Medication Misuse and Substance use Disorder in VA Primary Care Veterans with Chronic Pain.” General Hospital Psychiatry 30 (2): 93–9.
- Nahin, R. L. 2017. “Severe Pain in Veterans: The Effect of Age and Sex, and Comparisons with the General Population.” J Pain 18 (3): 247–54.
- Otis, J. D., T. M. Keane, and R. D. Kerns. 2003. “An Examination of the Relationship between Chronic Pain and Post-Traumatic Stress Disorder.” Journal of Rehabilitation Research and Development 40 (5): 397–405.
- Peterson, K., J. Anderson, L. Ferguson, and K. Mackey. 2016. “ Evidence Brief: The Comparative Effectiveness of Selected Complementary and Integrative Health (CIH) Interventions for Preventing or Reducing Opioid Use in Adults with Chronic Neck, Low Back, and Large Joint Pain.” VA Evidence-based Synthesis Program Evidence Briefs.
- Phifer, J., K. Skelton, T. Weiss, A. C. Schwartz, A. Wingo, C. F. Gillespie, L. A. Sands, S. Sayyar, B. Bradley, T. Jovanovic, and K. J. Ressler. 2011. “Pain Symptomatology and Pain Medication Use in Civilian PTSD.” Pain 152 (10): 2233–40.
- Pizer, S. D., and J. A. Gardner. 2011. “Is Fragmented Financing Bad for Your Health?” Inquiry 48 (2): 109–22.
- Reifler, L. M., D. Droz, J. E. Bailey, S. H. Schnoll, R. Fant, R. C. Dart, and B. B. Bartelson. 2012. “Do Prescription Monitoring Programs Impact State Trends in Opioid Abuse/Misuse?” Pain Med 13 (3): 434–42.
- Saunders, K. W., K. M. Dunn, J. O. Merrill, M. Sullivan, C. Weisner, J. B. Braden, B. M. Psaty, and M. Von Korff. 2010. “Relationship of Opioid Use and Dosage Levels to Fractures in Older Chronic Pain Veterans.” Journal of General Internal Medicine 25 (4): 310–5.
- Seal, K. H., Y. Shi, G. Cohen, B. E. Cohen, S. Maguen, E. E. Krebs, and T. C. Neylan. 2012. “Association of Mental Health Disorders with Prescription Opioids An High-Risk Opioids Use in US Veterans of Iraq and Afghanistan.” Journal of the American Medical Association 307 (9): 940–7.
- Solomon, D. H., J. A. Raassen, R. J. Glynn, J. Lee, R. Levin, and S. Schneeweiss. 2010. “The Comparative Safety of Analgesics in Older Adults with Arthritis.” Archives of Internal Medicine 170 (22): 1968–78.
- Stewart, W. F., J. A. Ricci, E. Chee, D. Morganstein, and R. Lipton. 2003. “Lost Productive Time and Cost Due to Common Pain Conditions in the US Workforce.” Journal of the American Medical Association 290 (18): 2443–54.
- Strong, J., R. Ashton, and D. Chant. 1991. “Pain Intensity Measurement in Chronic Low Back Pain.” Clinical Journal of Pain 7 (3): 209–18.
- Stroupe, K. T., B. M. Smith, T. P. Hogan, J. R. St Andre, W. F. Gellad, S. Weiner, T. A. Lee, M. Burk, F. Cunningham, J. D. Piette, T. J. Rogers, Z. Huo, and F. M. Weaver. 2013. “Medication Acquisition across Systems of Care and Patient–Provider Communication among Older Veterans.” American Journal of Health System Pharmacy 70 (9): 804–13.
- The White House: Office of the Press Secretary. 2017. “ President Donald J. Trump is Taking Action on Drug Addiction and the Opioid Crisis.” Washington, DC: The White House [accessed on November 28, 2017]. Available at https://www.whitehouse.gov/the-press-office/2017/10/26/president-donald-j-trump-taking-action-drug-addiction-and-opioid-crisis
- Toblin, R. L., P. J. Quartana, L. A. Riviere, K. C. Walper, and C. W. Hoge. 2014. “Chronic Pain and Opioid Use in US Soldiers after Combat Deployment.” JAMA Internal Medicine 174 (8): 1400–1.
- “ VA Information Resource Center, Record and Person Counts in the VA/CMS Medicare Data, CY 1997-2013.” Hines, IL: U.S. Dept. of Veterans Affairs, Health Services Research and Development Service, VA Information Resource Center. 2015.
- VIReC Support for VA/CMS Data provided by the Department of Veterans Affairs, VA Health Services Research and Development Service, VA Information Resource Center (Project Numbers SDR 02-237 and 98-004), Hines, IL. 2016.
- Wilsey, B. L., S. M. Fishman, A. M. Gilson, C. Casamalhuapa, H. Baxi, and H. Zhang. 2010. “Profiling Multiple Provider Prescribing of Opioids, Benzodiazepines, Stimulants, and Anorectics.” Drug and Alcohol Dependence 112: 99–106.
- Wolinsky, F. D., T. R. Miller, H. An, P. R. Brezinski, T. E. Vaughn, and G. E. Rosenthal. 2006. “Dual Use of Medicare and the Veterans Health Administration: Are There Adverse Health Outcomes?” BMC Health Serv Res 6: 1–11.
- Woolf, A. D., T. Vos, and L. March. 2010. “How to Measure the Impact of Musculoskeletal Conditions.” Best Pract Res Clin Rheumol 24: 723–32.
- Zale, E. L., S. A. Maisto, and J. W. Ditre. 2015. “Interrelations between Pain and Alcohol: An Integrative Review.” Clin Psychol Rev 37: 57–71.