Volume 117, Issue 2 pp. 253-257

Article

Protein Expression of the Tumor Suppressors p16INK4A and p53 and Disease Progression in Recurrent Respiratory Papillomatosis

Truc T. Pham MD,

Truc T. Pham MD

Department of Pathology, University of California–San Diego, San Diego, California, U.S.A.

*T.T.P. and W.M.O. contributed equally to this work.

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Weg M. Ongkeko MD, PhD,

Corresponding Author

Weg M. Ongkeko MD, PhD

[email protected]

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of California–San Diego, San Diego, California, U.S.A.

*T.T.P. and W.M.O. contributed equally to this work.

Weg M. Ongkeko, MD, PhD, University of California–San Diego, Basic Science Building Rm. 1109, Mail Code 0612, 9500 Gilman Dr., La Jolla, CA 92093, U.S.A.Search for more papers by this author

Yi An,

Yi An

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of California–San Diego, San Diego, California, U.S.A.

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Eunhee S. Yi MD,

Eunhee S. Yi MD

Department of Pathology, University of California–San Diego, San Diego, California, U.S.A.

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Truc T. Pham MD,

Truc T. Pham MD

Department of Pathology, University of California–San Diego, San Diego, California, U.S.A.

*T.T.P. and W.M.O. contributed equally to this work.

Search for more papers by this author

Weg M. Ongkeko MD, PhD,

Corresponding Author

Weg M. Ongkeko MD, PhD

[email protected]

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of California–San Diego, San Diego, California, U.S.A.

*T.T.P. and W.M.O. contributed equally to this work.

Weg M. Ongkeko, MD, PhD, University of California–San Diego, Basic Science Building Rm. 1109, Mail Code 0612, 9500 Gilman Dr., La Jolla, CA 92093, U.S.A.Search for more papers by this author

Yi An,

Yi An

Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of California–San Diego, San Diego, California, U.S.A.

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Eunhee S. Yi MD,

Eunhee S. Yi MD

Department of Pathology, University of California–San Diego, San Diego, California, U.S.A.

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First published: 02 January 2009

https://doi.org/10.1097/01.mlg.0000248241.95357.a6

Citations: 6

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Abstract

Background: Recurrent respiratory papillomatosis (RRP) is a benign condition that rarely metastasizes as invasive squamous cell carcinoma. Although this disease is associated with human papillomavirus, the role of this virus in tumorigenesis is unclear.

Objectives: The aim of this study is to assess the involvement of the tumor suppressors P16INK4A and p53 in RRP tumor progression.

Design: Immunohistochemistry of p16INK4A and p53 was performed on biopsies of recurrent squamous papillomas and invasive lesions in nine patients.

Results: Twenty biopsies were graded as papillomas (RP), three as papillomas with high-grade dysplasia/carcinoma in situ (HGD/CIS), and two as invasive squamous cell carcinoma (SCCA). Forty-five percent of RP and 60% of HGD/CIS/SCCA expressed p16INK4A. Fifty percent of RP and 100% of HGD/CIS/SCCA expressed p53. The difference in the frequency of p53-positive staining between HGD/CIS and SCCA (100% of tissues examined) and RP (50% of tissues examined) approached statistical significance. Neither p16INK4A nor p53 was predictive of invasive transformation.

Conclusions: Expression of p16INK4A, which is a surrogate for the tumor suppressor retinoblastoma (Rb), did not immediately lead to invasive disease. There is no correlation between disease severity of RRP and level of p16INK4A.

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Volume117, Issue2

February 2007

Pages 253-257

Protein Expression of the Tumor Suppressors p16INK4A and p53 and Disease Progression in Recurrent Respiratory Papillomatosis

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Protein Expression of the Tumor Suppressors p16INK4A and p53 and Disease Progression in Recurrent Respiratory Papillomatosis

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