Complications of pancreatic surgery
CHOON-KIAT HO,
JÖRG KLEEFF,
HELMUT FRIESS,
MARKUS W. BÜChler,
CHOON-KIAT HO
Department of General Surgery, University of Heidelberg, Germany
Search for more papers by this authorJÖRG KLEEFF
Department of General Surgery, University of Heidelberg, Germany
Search for more papers by this authorHELMUT FRIESS
Department of General Surgery, University of Heidelberg, Germany
Search for more papers by this authorCorresponding Author
MARKUS W. BÜChler
Department of General Surgery, University of Heidelberg, Germany
Markus W. Büchler MD, Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. Fax: +49 6221 56 6903. E-mail: [email protected]Search for more papers by this authorCHOON-KIAT HO,
JÖRG KLEEFF,
HELMUT FRIESS,
MARKUS W. BÜChler,
CHOON-KIAT HO
Department of General Surgery, University of Heidelberg, Germany
Search for more papers by this authorJÖRG KLEEFF
Department of General Surgery, University of Heidelberg, Germany
Search for more papers by this authorHELMUT FRIESS
Department of General Surgery, University of Heidelberg, Germany
Search for more papers by this authorCorresponding Author
MARKUS W. BÜChler
Department of General Surgery, University of Heidelberg, Germany
Markus W. Büchler MD, Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. Fax: +49 6221 56 6903. E-mail: [email protected]Search for more papers by this authorAbstract
Pancreatic resection is the only treatment option that can lead to a meaningful prolonged survival in pancreatic cancer and, in some instances, perhaps a potential chance for cure. With the advent of organ and function preserving procedures, its use in the treatment of chronic pancreatitis and other less common benign diseases of the pancreas is increasing. Furthermore, over the past two decades, with technical advances and centralization of care, pancreatic surgery has evolved into a safe procedure with mortality rates of <5%. However, postoperative morbidity rates are still substantial. This article reviews the more common procedure-related complications, their prevention and their treatment.
References
- [1] Yeo CJ, Cameron JL, Sohn TA, Lillemoe KD, Pitt HA, Talamini MA, et al. Six hundred fifty consecutive pancreaticoduodenectomy in the 1990s: pathology, complications, and outcomes. Ann Surg 1997; 226: 248–57.
- [2] Stojadinovic A, Brooks A, Hoos A, Jaques DP, Conlon KC, Brennan MF. An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma. J Am Coll Surg 2003; 196: 6: 954–64.
- [3] Crist DW, Sitzmann JV, Cameron JL. Improved hospital morbidity, mortality and survival after the Whipple procedure. Ann Surg 1987; 206: 358–65.
- [4] Büchler MW, Wagner M, Schmied BM, Uhl W, Friess H, Z'graggen K. Changes in mortality after pancreatic resection: towards the end of completion pancreatectomy. Arch Surg 2003; 138: 1310–14.
- [5] Balcom JH, Rattner DW, Warshaw AL, Chang Y, Fernandez-del Castillo C. Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg 2001; 136: 391–8.
- [6] Richter A, Niedergethmann M, Sturm JW, Lorenz D, Post S, Trede M. Long-term results of pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg Mar: 2003; 27: 3: 324–9.
- [7] Strasberg SM, Drebin JA, Soper NJ. Evolution and current status of the Whipple procedure: an update for gastroenterologists. Gastroenterology 1997; 113: 983–94.
- [8] Cancer Statistics 2004. American Cancer Society. http://www.cancer.org.
- [9] Greenlee RT, Murray T, Boldon S, Wingo PA. Cancer statistics. CA Cancer J Clin 2000; 50: 7–33.
- [10] Bramhall SR, Neoptolemos JP. Adjuvant chemotherapy in pancreatic cancer. Int J Pancreatol 1997; 21: 59.
- [11]
Büchler M,
Friess H,
Schultheiss KH,
Gebhard C,
Kubel R,
Muhrer KH,
Winkelmann M,
Wagener T,
Klapdor R,
Kaul M.
A randomized controlled trial of adjuvant immunotherapy (murine monoclonal antibody 494/32) in resectable pancreatic cancer.
Cancer
1991; 68: 1507.
10.1002/1097-0142(19911001)68:7<1507::AID-CNCR2820680707>3.0.CO;2-0 CAS PubMed Web of Science® Google Scholar
- [12] Friess H, Büchler M, Beglinger C, Weber A, Kunz J, Fritsch K, Dennler HJ, Beger HG. Low-dose octreotide treatment is not effective in patients with advanced pancreatic cancer. Pancreas 1993; 8: 540.
- [13] Friess H, Büchler M, Kruger M, Beger HG. Treatment of duct carcinoma of the pancreas with the LH-RH analogue Buserelin. Pancreas 1992; 7: 516.
- [14] Nishimura Y, Hosotani R, Shibamoto Y, Kokubo M, Kanamori S, Sasai K, Hiraoka M, Ohshio G, Imamura M, Takahashi M, et al. External and intraoperative radiotherapy for resectable and unresectable pancreatic cancer: Analysis of survival rates and complications. Int J Radiat Oncol Biol Phys 1997; 39: 39.
- [15] Beger HG, Rau B, Gansauge F, Poch B. Treatment of pancreatic cancer: challenge of the facts. World J Surg 2003; 27: 1075–84.
- [16] American Gastroenterological Association American Gastroenterological Association medical position statement: epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. Gastroenterology 1999; 117: 1463–84.
- [17] Wagner M, Redaelli C, Lietz M, Seiler CA, Friess H, Büchler MW. Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. BJS 2004; 91: 586–94.
- [18] Schafer M, Müllhaupt B, Clavien PA. Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitis. Ann Surg 2002; 236: 2: 137–48.
- [19] Frey CF. The surgical management of chronic pancreatitis: the Frey procedure. Adv in Surg 1999; 32: 41–83.
- [20] Beger HG, Schlosser W, Siech M, Poch B. The surgical management of chronic pancreatitis: Duodenum-preserving pancreatectomy. Adv in Surg 1999; 32: 87–105.
- [21] Sohn TA, Campbell KA, Pitt HA, Sauter PK, Coleman J, Lillemoe KD, Yeo CJ, Cameron JL. Quality of life and long-term survival after surgery for chronic pancreatitis. J Gastrointest Surg 2004; 4: 355–65.
- [22] Bradley EL III. Pancreatoduodenectomy for pancreatic adenocarcinoma: Triumph, Triumphalism or Transition. World J Surg 2002; 137: 771–3.
- [23] Gilsdorf RB, Spanos P. Factors influencing morbidity and mortality in pancreaticoduodenectomy. Ann Surg 1973 332–7.
- [24] Bakkevoid KE, Kambestad B. Morbidity and mortality after radical and palliative pancreatic cancer surgery. Risk factors influencing the short-term results. Ann Surg 1993; 217: 356–68.
- [25] Halloran CM, Ghaneh P, Bosonnet L, Hartley MN, Sutton R, Neoptolemos JP. Complications of pancreatic cancer resection. Dig Surg 2002; 19: 138–46.
- [26] Büchler MW, Friess H, Wagner M, Kulli C, Wagener V, Z'graggen K. Pancreatic fistula after pancreatic head resection. BJS 2000; 87: 883–9.
- [27] Wagner M, Z'graggen K, Vagianos, Redaelli CA, Holzinger F, Sadowski C, et al. Pylorus-preserving total pancreatectomy: early and late results. Dig Surg 2001; 18: 188–95.
- [28] Büchler MW, Friess H, Müller MW, Wheatley AM, Beger HU. Randomized trial of duodenum-preserving pancreatic head resection versus pyloric-preserving Whipple in chronic pancreatitis. Am J Surg 1995; 169: 65–70.
- [29] Warshaw AL, Rattner DW, Fernandez-del Castillo C, Z'graggen K. Middle segment pancreatectomy: a novel technique for conserving pancreatic tissue. Arch Surg 1998; 133: 327–31.
- [30]
Balcom J,
Fernandez-del Castillo C,
Warshaw AL.
Cystic lesions in the pancreas: when to watch, when to resect.
Curr Gastroenterol Rep
2001; 2: 152–8.
10.1007/s11894-000-0099-4 Google Scholar
- [31] Birkmeyer JD, Siewers AE, Finlayson EVA, et al. Hospital volume and surgical mortality in the United States. N Engl J Med 2002; 346: 1128–37.
- [32] Liebermann MD, Killborn H, Lindsey M, et al. Relation of perioperative deaths to hospital volume among patients undergoing pancreatic resection for malignancy. Ann Surg 1995; 222: 786–94.
- [33] Gouma DJ, van Geenen RCI, van Gulik THM. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Ann Surg 2000; 232: 786–94.
- [34] Bramhall SR, Allum WH, Jones AG, et al. Treatments and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br J Surg 1995; 82: 111–5.
- [35] Neoptolemos JP, Russel RCG, Bramhale S, et al. Low mortality following resection for pancreatic and periampullary tumours in 1026 patients. Br J Surg 1997; 84: 1370.
- [36] Gordon TA, Bowman HM, Bass EB, et al. Complex gastrointestinal surgery: impact of provider experience on clinical and economic outcomes. J Am Coll Surg 1999; 189: 46–56.
- [37] Scand J Finnish Surg Society Annual Meeting (1996) 17–45 http://www.fimnet.fi.
- [38] Birkmeyer JD, Finlayson SRG, Toeteson ANA, et al. Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy. Surgery 1999; 125: 250–6.
- [39] Birkmeyer JD, Warshaw AL, Finlayson SR, Grove MR, Tosteson AN. Relationship between hospital volume and late survival after pancreaticoduodenectomy. Surgery 1999; 126: 2: 178–83.
- [40] Cooperman MM, Schwartz ET, Fader A, et al. Safety, efficacy and cost of pancreaticoduodenal resection in a specialized center based at a community hospital. Arch Surg 1997; 132: 744–8.
- [41] Hutchins RR, Kojodjojo P, Ho R, Bani-Hani A, Snooks SJ. Short and long-term outcome of pancreatic surgery in a district general hospital. J R Coll Surg Edinb 2002; 47: 3: 548–51.
- [42] Afsari A, Zhandoug Z, Young S, Feruson L, Silapaswan S, Mittal V. Oucome analysis of pancreaticoduodenectomy at a community hospital. Am Surg 2002; 68: 3: 281–5.
- [43] Birkmeyer JD, Stukel TA, Siewers AE, Goodney PP, Wennberg DE, Lucas FL. Surgeon volume and operative mortality in the United States. N Engl J Med 2003; 329: 22: 2117–27.
- [44] Dimick JB, Pronovost PJ, Cowan JA Jr, Lipsett PA, Stanley JC, Upchurch GR Jr. Variation in postoperative complication rates after high-risk surgery in the United States. Surgery 2003; 134: 534–41.
- [45] Cullen JJ, Sarr MG, Ilstrup D. Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance and management. Am J Surg 1994; 168: 295–8.
- [46] Berberat PO, Friess H, Kleeff J, Uhl W, Büchler MW. Prevention and treatment of complications in pancreatic cancer surgery. Dig Surg 1999; 16: 327–36.
- [47] Conlon KC, Labow D, Leung D, Smith A, Jamagin W, Coit DG, et al. Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection. Ann Surg 2001; 234: 487–94.
- [48] Suzuki Y, Fujino Y, Tanioka Y, Hiraoka K, Takada M, Ajiki T, Takeyama Y, Ku Y, Kuroda Y. Selection of pancreaticojejunostomy techniques according to pancreatic texture and duct size. Arch Surg 2002; 137: 1044–7.
- [49] Bassi C, Falconi M, Salvia R, Mascetta G, Molinari E, Pederzoli P. Management of complications after pancreaticoduodenectomy in a High Volume Centre: results on 150 consecutive patients. Dig Surg 2001; 18: 453–7.
- [50] Van Berge Henegouwen MI, De Wit LT, Van Gulik TM, Obertop H, Gouma DJ. Incidence, risk factors and treatment of pancreatic leakage after pancreaticoduodenectomy: drainage versus resection of the pancreatic remnant. J Am Coll Surg 1997; 185: 18–24.
- [51] Büchler M, Friess H, Klempa I, Hermanek P, Sulkowski U, Becker H, Schafmayer A, Baca I, Lorenz D, Meister R. Role of octreotide in the prevention of postoperative complications following pancreatic resection. Am J Surg 1992; 163: 125–30.
- [52] Yeo CJ, Cameron JL, Lillemoe KD, Sauter PK, Coleman J, Sohn TA, et al. Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy: results of a prospective randomized placebo-controlled trial. Ann Surg 2000; 232: 3: 419–29.
- [53] Suc B, Msika S, Piccinini M, Fourtanier G, Hay JM, Flamant Y, Fingerhut A, Fagniez PL, Chipponi J. Octreotide in the prevention of intra-abdominal complications following elective pancreatic resection: A prospective, multicenter randomized controlled trial. Arch Surg 2004; 139: 288–94.
- [54] Friess H, Malfertheiner P, Isenmann R, Kuhne H, Beger HG, Büchler MW. The risk of pancreaticointestinal anastomosis can be predicted preoperatively. Pancreas 1996; 13: 202–8.
- [55] Bartoli FG, Arnone GB, Ravera G, Bachi V. Pancreatic fistula and relative mortality in malignant disease after pancreaticoduodenectomy. Review and statistical meta-analysis regarding 15 years of literature. Anticancer Res 1991; 11: 1831–48.
- [56] Pederzoli P, Bassi C, Falconi M, Camboni MG. Efficacy of octreotide in the prevention of complications of elective pancreatic surgery: Italian Study Group. Br J Surg 1994; 81: 265–9.
- [57] Montorsi M, Zago M, Mosca F, Capussotti L, Zotti E, Ribotta G, et al. Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery 1995; 117: 26–31.
- [58] Friess H, Beger HG, Sulkowski U, Becker H, Hofbauer B, Dennler HJ, et al. Randomized controlled multicentre study of the prevention of complications by octreotide for patients undergoing surgery for chronic pancreatitis. Br J Surg 1995; 82: 1270–3.
- [59] Lowy AM, Lee JE, Pisters PWT, Davidson BS, Fenoglio CJ, Stanford P, et al. Prospective randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg 1997; 226: 632–41.
- [60] Sarr MG. Pancreatic Surgery Group The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. J Am Coll Surg 2003; 196: 556–65.
- [61] Rosenberg L, MacNeil P, Turcotte L. Economic evaluation of the use of octreotide for the prevention of complications following pancreatic resection. J Gastrointest Surg 1999; 3: 225–32.
- [62] Li-Ling J, Irving M. Somatostatin and octreotide in the prevention of postoperative pancreatic complications and the treatment of enterocutaneous pancreatic fistulas: a systematic review of randomized controlled trials. Br J Surg 2001; 88: 190–9.
- [63] Shu YP, Yi PM, Yin BL, Ying S, Cheng HP, Xiu JC, Yu LW, Lin HZ. Binding pancreaticojejunostomy: 150 consecutive cases without leakage. J Gastrointest Surg 2003; 7: 898–900.
- [64] Tanaka T, Matsugu Y, Fukuda Y. Use of ultrasonically activated shears improves the safety of pancreaticojejunostomy after pancreaticoduodenectomy. Arch Surg 2002; 137: 1258–61.
- [65] Yeo CJ, Cameron JL, Maher MM, et al. A prospective randomized trial of pancreaticogastrostomy and pancreaticojejunostomy after pancreaticoduodenectomy. Ann Surg 1995; 222: 580–8.
- [66] Chou FF, Sheen-Chen SM, Chen YS, et al. Postoperative morbidity and mortality of pancreaticoduodenectomy for periampullary cancer. Eur J Surg 1996; 162: 477–81.
- [67] Matsumoto Y, Fujii H, Miura K, Inoue S, Sekikawa T, Aoyama H, Ohnishi N, Sakai K, Suda K. Successful pancreatojejunal anastomosis for pancreatoduodenectomy. Surg Gynecol Obstet 1992; 175: 555–62.
- [68] Hosotani R, Doi R, Imamura M. Duct-to-mucosa pancreaticojejunostomy reduces the risk of pancreatic leakage after pancreatoduodenectomy. World J Surg 2002; 26: 99–104.
- [69] Z'graggen K, Uhl W, Friess H, Büchler MW. How to do a safe pancreatic anastomosis. J Hepatobiliary Pancreat Surg 2002; 9: 733–7.
- [70] Roder JD, Stein HJ, Bottcher KA, Busch R, Heidecke CD, Siewert JR. Stented versus non-stented pancreaticojejunostomy after pancreatoduodenectomy: a prospective study. Ann Surg 1999; 229: 41–8.
- [71] Kingsnorth AN. Safety and function of isolated Roux loop pancreaticojejunostomy after Whipple's pancreaticoduodenectomy. Ann R Coll Surg Engl 1994; 76: 175–9.
- [72] Matsusue S, Takeda H, Nakamura Y, Nishimura S, Koizumi S. A prospective analysis of factors influencing pancreaticojejunostomy performed using a single method, in 100 consecutive pancreaticoduodenectomies. Surg Today 1998; 28: 719–26.
- [73] Tran K, van Eijck C, Di Carlo V, et al. Occlusion of the pancreatic duct versus pancreaticojejunostomy: a prospective randomized trial. Ann Surg 2002; 236: 422–8.
- [74] D'Andrea AA, Costantino V, Sperti C, Pedrazzoli S. Human fibrin sealant in pancreatic surgery: is it useful in preventing fistula? A prospective randomized study. Ital J Gastroenterol 1994; 26: 283–6.
- [75] Suc B, Msika S, Fingerhut A, Fourtanier G, Hay JM, Holmieres F, et al. the French Associations for Surgical Research Temporary fibrin glue occlusion of the main pancreatic duct in the prevention of intra-abdominal complications after pancreatic resection. Ann Surg 2003; 237: 57–65.
- [76] Torres AJ, Landa JI, Moreno-Azcoita M, Arguello JM, Silecchia G, Castro J, Hernandez-Merlo F, Jover JM, Moreno-Gonzales E, Balibrea JL. Somatostatin in the management of gastrointestinal fistulas. A multicenter trial. Arch Surg 1992; 127: 97–9.
- [77] Sancho JJ, di Costanzo J, Nubiola P, Larrad A, Beguiristain A, Roqueta F, Franch G, Oliva A, Gubern JM, Sitges-Serra A. Randomized double-blind placebo controlled trial of early octreotide in patients with post-operative enterocutaneous fistula. Br J Surg 1995; 82: 638–41.
- [78] Nubiola P, Badia JM, Martinez-Rodenas F, Gill MJ, Segura M, Sancho JJ, Sitges-Serra A. Treatment of 27 postoperative enterocutaneous fistulas with long half-life somatostatin analogue SMS 201–995. Ann Surg 1989; 219: 56–8.
- [79] Bassi C, Falconi M, Salvia R, Caldiron E, Butturini G, Pederzoli P. Role of octreotide in the treatment of external pancreatic pure fistula: a single-institution prospective experience. Langenbecks Arch Surg 2000; 385: 10–13.
- [80] Alvarez C, McFadden DW, Reber HA. Complicated enterocutaneous fistula: failure of octreotide to improve healing. World J Surg 2000; 24: 533–7.
- [81] Farley DR, Schwall G, Trede M. Completion pancreatectomy for complications after pancreaticoduodenectomy. Br J Surg 1996; 83: 176–9.
- [82] Trede M, Saeger HD, Schwall G, Rumstadt B. Resection of pancreatic cancer: surgical achievements. Langenbecks Arch Surg 1998; 383: 121–8.
- [83] Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Goodman SN, Dooley WC, Coleman J, Pitt HA. Pancreaticoduodenectomy for cancer of the head of the pancreas. Ann Surg 1995; 221: 721–33.
- [84] Adam U, Makowiec F, Riediger H, Schareck WD, Benz S, Hopt UT. Risk factors for complications after pancreatic head resection. Am J Surg 2004; 187: 201–8.
- [85] Rumstadt B, Schwab M, Korth P, Samman M, Trede M. Hemorrhage after pancreatoduodenectomy. Ann Surg 1998; 227: 236–41.
- [86] Martignoni ME, Wagner M, Krahenbühl L, Redaelli CA, Friess H, Büchler MW. Effect of preoperative biliary drainage on surgical outcome after pancreaticoduodenectomy. Am J Surg 2001; 181: 52–9. discussion 87.
- [87] Van Berge Henegouwen MI, Allema JH, Van Gulik TM, Verbeek PC, Obertop H, Gouma DJ. Delayed massive hemorrhage after pancreatic and biliary surgery. Br J Surg 1995; 82: 1527–31.
- [88] Sewnath ME, Karsten TM, Prins MH, Rauws EJA, Obertop H, Gouma DJ. A meta-analysis on the efficacy of preoperative biliary drainage for tumours causing obstructive jaundice. Ann Surg 2002; 236: 1: 17–27.
- [89] Saleh MMA, Nørregaard P, Jørgensen HL, Andersen PK, Matzen P. Preoperative endoscopic stent placement before pancreaticoduodenectomy: a meta-analysis of the effect on morbidity and mortality. Gastrointest Endosc 2002; 56: 529–34.
- [90] Brodsky JT, Turnbull AD. Arterial hemorrhage after pancreaticoduodenectomy. The ‘sentinel bleed’. Arch Surg 1991; 126: 1037–40.
- [91] Shankar R, Russell RCG. Hemorrhage in pancreatic disease. Br J Surg 1995; 82: 1527–31.
- [92] Horstmann O, Markus PM, Ghadimi MB, Becker H. Pylorus preservation has no impact on delayed gastric emptying after pancreatic head resection. Pancreas 2004; 28: 69–74.
- [93] Van Berge Henegouwen MI, Van Gulik TM, Dewit LT, Allema JH, Rauws EA, Obertop H, Gouma DJ. Delayed gastric emptying after standard pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: an analysis of 200 consecutive patients. J Am Coll Surg 1997; 185: 373–9.
- [94] Jimenez RE, Fernandez-del Castillo C, Rattner DW, Chang Y, Warshaw AL. Outcome of pancreaticoduodenectomy with pylorus preservation or with antrectomy in the treatment of chronic pancreatitis. Ann Surg 2000; 231: 293–300.
- [95] Roder JD, Stein HJ, Huttl W, Siewert JR. Pylorus preserving versus standard pancreaticoduodenectomy: an analysis of 110 pancreatic and periampullary carcinomas. Br J Surg 1992; 79: 152–5.
- [96] Di Carlo V, Zerbi A, Balzano G, Corso V. Pylorus-preserving pancreaticoduodenectomy versus conventional Whipple operation. World J Surg 1999; 23: 920–5.
- [97] Mosca F, Giulianotti PC, Balestracci T, Di Candio G, Pietrabassa A, Sbrana F, et al. Long term survival in pancreatic cancer: pylorus-preserving versus Whipple pancreatoduodenectomy. Surgery 1997; 122: 553–66.
- [98] Lin PW, Lin YJ. Prospective randomized comparison between pylorus-preserving and standard pancreaticoduodenectomy. Br J Surg 1999; 86: 603–7.
- [99] Izbicki JR, Bloechle C, Broering DC, Knoefel WT, Kuechler T, Broelsch CE. Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg 1998; 228: 771–9.
- [100] Riediger H, Makowiec F, Schareck WD, Hopt UT, Adam U. Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications. J Gastrointest Surg 2003; 7: 758–65.
- [101] Yeo CJ, Cameron JL, Sohn TA, Coleman J, Sauter PK, Hruban RH, Pitt HA, Lillemoe KD. Pancreatoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short term exposure. Ann Surg 1999; 228: 613–22.
- [102] Pedrazzoli S, Di Carlo V, Dionigi R, Mosca F, Pederzoli P, Pasquali C, Kloppel G, Dhaene K, Michelassi F. Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multi-centre prospective randomized study. Lymphadenectomy Study Group. Ann Surg 1998; 28: 508–17.
- [103] Yeo CJ, Barry K, Sauter PK, Sostre S, Lillemoe KD, Pitt HA, Cameron CJ. Erythromycin accelerates gastric emptying after pancreatoduodenectomy. Ann Surg 1993; 218: 229–38.
- [104] Cooperman AM. Surgery and chronic pancreatitis. Surg Clin North Am 2001; 81: 2: 431–54.
- [105] Frey CF, Kathrin LM. Comparison of local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy (Frey procedure) and duodenum-preserving resection of the pancreatic head (Beger procedure). World J Surg 2003; 27: 1217–30.
- [106] Izbicki JR, Bloechle C, Knoefel WT, Kuechler T, Binmoeller KF, Soehendra N, et al. [Drainage versus resection in surgical therapy of chronic pancreatitis of the head of the pancreas: a randomized study]. Chirurg 1997; 68: 369–77.
- [107] Malka D, Hammel P, Sauvanet A, Rufat P, O'Toole D, Bardet P, et al. Risk factors for diabetes mellitus in chronic pancreatitis. Gastroenterology 2000; 119: 1324–32.
- [108] Klempa I, Spatny M, Menzel J, Baca I, Nustede R, Stockmann F, et al. [Pancreatic function and quality of life after resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized comparative study after duodenum preserving resection of the head of the pancreas versus Whipple's operation]. Chirurg 1995; 66: 350–9.
- [109] Aldridge MC, Williamson RCN. Distal pancreatectomy with and without splenectomy. Br J Surg 1991; 78: 976–9.
- [110] Sheehan MK, Beck K, Creech S, Pickleman J, Aranha GV. Distal pancreatectomy: does the method of closure influence fistula formation. Am Surgeon 2002; 68: 3: 264–8.
- [111] Fahy BN, Frey CF, Ho HS, Beckett L, Bold RJ. Morbidity, mortality, and technical factors of distal pancreatectomy. Am J Surg 2002; 183: 237–41.
- [112] Castillo CF, Rattner DW, Warshaw AL. Standards for pancreatic resection in the 1990s. Arch Surg 1995; 130: 295–300.
- [113] Bilimoria MM, Evans DB, Lee JE, et al. Pancreatic closure after distal pancreatectomy: relationship to postoperative pancreatic fistula. Presented at the 53rd Annual Cancer Symposium of the Society of Surgical Oncology, New Orleans, LA, Mar. 16–19, 2000.
- [114] Kajiyama Y, Tsurumaru M, Udagawa H, Tsustumi K, Kinoshita Y, Akiyama H. Quick and simple distal pancreatectomy using the GIA staple: report of 35 cases. Br J Surg 1996; 83: 1711.
- [115] Takeuchi K, Tsuzuki Y, Ando T, Sekihara M, Hara T, Kori T, Nakajima H, Kuwano H. Distal pancreatectomy: is staple closure beneficial. ANZ J Surg 2003; 73: 922–5.
- [116] Yellin AE, Vecchione TR, Donovan AJ. Distal pancreatectomy for pancreatic trauma. Am J Surg 1972; 124: 135–42.
- [117] Benoist S, Dugue L, Sauvanet A, Valverde A, Mauvais F, Paye F, et al. Is there a role of preservation of the spleen in distal pancreatectomy. J Am Coll Surg 1999; 188: 255–60.
- [118] Richardson DQ, Scott-Conner CEH. Distal pancreatectomy with and without splenectomy: a comparative study. Am Surg 1989; 55: 21–5.
- [119] Trede M, Schwall G, Seger HD. Survival after pancreatoduodenectomy. 118 consecutive resections without an operative mortality. Ann Surg 1990; 211: 447–58.
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