Efficacy of Stronger Neo-Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis
Corresponding Author
Kazuhiko Miyake
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Professor K Miyake, Department of Internal Medicine, Teikyo Univeristy School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. Email: [email protected]Search for more papers by this authorToshiro Tango
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorYasuhiko Ota
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorKeiji Mitamura
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorMakoto Yoshiba
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorMakoto Kako
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorShigeki Hayashi
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Present address: Social Insurance Tonan General Hospital, Tokyo, Japan.
Search for more papers by this authorYusei Ikeda
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorNorimasa Hayashida
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorShogo Iwabuchi
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorYuzuru Sato
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorToshiaki Tomi
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorNaoya Funaki
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorNaoaki Hashimoto
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorTomoyuki Umeda
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorJun Miyazaki
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorKatsuaki Tanaka
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorYasuo Endo
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorHiroshi Suzuki
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorCorresponding Author
Kazuhiko Miyake
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Professor K Miyake, Department of Internal Medicine, Teikyo Univeristy School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. Email: [email protected]Search for more papers by this authorToshiro Tango
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorYasuhiko Ota
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorKeiji Mitamura
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorMakoto Yoshiba
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorMakoto Kako
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorShigeki Hayashi
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Present address: Social Insurance Tonan General Hospital, Tokyo, Japan.
Search for more papers by this authorYusei Ikeda
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorNorimasa Hayashida
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorShogo Iwabuchi
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorYuzuru Sato
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorToshiaki Tomi
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorNaoya Funaki
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorNaoaki Hashimoto
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorTomoyuki Umeda
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorJun Miyazaki
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorKatsuaki Tanaka
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorYasuo Endo
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorHiroshi Suzuki
* Teikyo University School of Medicine, Tokyo, † National Institute of Public Health, Tokyo, ‡ Toshiba Hospital, Tokyo, § Showa University School of Medicine,Tokyo, ¶ Showa University Fujigaoka Hospital, Kanagawa, * * Teikyo University Mizonokuchi Hospital, Kanagawa, † † International Medical Center of Japan, Tokyo, ‡ ‡ Tokyo Kosei-Nenkin Hospital, Tokyo, § § Kawakita General Hospital, Kanagawa, ¶ ¶ Kawasaki Abdominal Hospital, Kanagawa, * * * Kanto Medical Center of NTT East Corporation, Tokyo, † † † Jiseikai Hospital, Tokyo, ‡ ‡ ‡ Tokyo Senbai Hospital, Tokyo, § § § Tokyo Postal Services Agency Hospital, Tokyo, ¶ ¶ ¶ Tokyo Metropolitan Ebara Hospital, Tokyo, * * * * Tokyo Hitachi Hospital, Tokyo, † † † † Yokohama City University Medical Center, Kanagawa, ‡ ‡ ‡ ‡ Sanraku Hospital, Tokyo and § § § § Yamanashi Medical University, Yamanashi, Japan
Search for more papers by this authorPresent address: Ohfuna Chuo Hospital, Kanagawa, Japan.
Abstract
Background: A daily injection of glycyrrhizin (Stronger Neo-Minophagen C (SNMC) containing 40 mg glycyrrhizin in a 20 mL ampoule) lowers alanine aminotransferase (ALT) levels in patients with chronic viral hepatitis.
Methods: The therapeutic effects of intermittent administration of SNMC three times a week for 12 weeks were evaluated and compared between two doses (40 and 100 mL) in a randomized clinical trial.
Results: Overall, the therapeutic response was better in the 53 patients allocated 100 mL than the 59 who were allocated to have 40 mL SNMC (P = 0.0243). At the completion of SNMC treatment, ALT levels decreased more extensively in the patients on 100 mL than those on 40 mL SNMC (−29 vs−50% in comparison with the baseline value, P = 0.0002). Minor side-effects occurred in both the patients on 100 mL (20%) and those on 40 mL (12%), but they did not require any therapies.
Conclusions: Intermittent SNMC would be efficient in suppressing ALT levels in patients with chronic viral hepatitis in a dose-dependent manner. Taken along with infrequent and very mild side-effects, long-term intermittent SNMC would benefit patients with chronic hepatitis by maintaining their quality of life with easier compliance.
© 2002 Blackwell Publishing Asia Pty Ltd
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