A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)
Dr Kensuke Kojima, The First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791–0295, Japan. E-mail: [email protected]
Abstract
Summary. We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF–CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP–MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF–CBP and/or CBP–MORF fusion protein(s) might play an important role in the development of t-MDS.
