Clinical significance of the CALLY index in patients with gastric cancer undergoing gastrectomy
Corresponding Author
Katsunobu Sakurai
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Correspondence
Katsunobu Sakurai, 2-13-22 Miyakojima-hondori Miyakojima-ku, Osaka City, Osaka 534-0021, Japan.
Email: [email protected]
Contribution: Conceptualization, Formal analysis, Investigation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorNaoshi Kubo
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorTsuyoshi Hasegawa
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorJunya Nishimura
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorYasuhito Iseki
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorTakafumi Nishii
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorToru Inoue
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Validation
Search for more papers by this authorMasakazu Yashiro
Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorYukio Nishiguchi
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorKiyoshi Maeda
Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorCorresponding Author
Katsunobu Sakurai
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Correspondence
Katsunobu Sakurai, 2-13-22 Miyakojima-hondori Miyakojima-ku, Osaka City, Osaka 534-0021, Japan.
Email: [email protected]
Contribution: Conceptualization, Formal analysis, Investigation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorNaoshi Kubo
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorTsuyoshi Hasegawa
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorJunya Nishimura
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorYasuhito Iseki
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorTakafumi Nishii
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Investigation
Search for more papers by this authorToru Inoue
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Validation
Search for more papers by this authorMasakazu Yashiro
Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorYukio Nishiguchi
Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorKiyoshi Maeda
Department of Gastroenterological Surgery, Osaka Metropolitan University, Osaka, Japan
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorAbstract
Background
The aim of this study was to elucidate the clinical impact of the CALLY index in patients with gastric cancer (GC) undergoing gastrectomy.
Methods
Between January 2014 and December 2020, 617 patients who underwent gastrectomy for GC at the Osaka City General Hospital were enrolled in this study. The CALLY index was calculated using the following formula: [albumin (g/dL) × lymphocytes (/μl)]/[CRP (mg/dL) × 104]. We compared the predictive value of four biomarkers [CALLY index, modified Glasgow prognostic score (mGPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)] for short- and long-term outcomes and focused on the CALLY index to elucidate its clinical value.
Results
Receiver operating characteristic analysis showed that the area under the curve for the CALLY index was the highest among the four biomarkers. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates in the low and the high CALLY groups were statistically significant. Multivariate analysis identified the CALLY index as an independent factor for OS and CSS but not NLR or PLR. The mGPS was an independent factor for OS but not for CSS in multivariate analysis. Regarding complications, only the CALLY index was an independent predictor of major complications (≧ Clavien–Dindo grade 3) in multivariate analysis but not others.
Conclusions
The CALLY index may have a clinical value in predicting OS, CSS, and major complications in GC patients undergoing gastrectomy.
CONFLICT OF INTEREST STATEMENT
The authors declare that they have no conflicts of interest for this article.
Supporting Information
| Filename | Description |
|---|---|
| wjs12357-sup-0001-suppl-data.docx12.5 KB | Supporting Information S1 |
| wjs12357-sup-0002-suppl-data.docx12.5 KB | Supporting Information S1 S2 |
| wjs12357-sup-0003-fig_s1.png170.6 KB | Figure S1 |
| wjs12357-sup-0004-fig_s2.png171.5 KB | Figure S2 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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