Extruded poly (glycerol sebacate) and polyglycolic acid vascular graft forms a neoartery
Takuma Fukunishi
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorCecillia Lui
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorChin Siang Ong
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorTyler Dunn
Section of Cardiac Surgery, University of Chicago, Chicago, Illinois, USA
Search for more papers by this authorShanxiu Xu
Section of Cardiac Surgery, University of Chicago, Chicago, Illinois, USA
Search for more papers by this authorCarissa Smoot
The Secant Group, LLC, Telford, Pennsylvania, USA
Search for more papers by this authorJeremy Harris
The Secant Group, LLC, Telford, Pennsylvania, USA
Search for more papers by this authorPeter Gabriele
The Secant Group, LLC, Telford, Pennsylvania, USA
Search for more papers by this authorLakshmi Santhanam
Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorCorresponding Author
Narutoshi Hibino
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Section of Cardiac Surgery, University of Chicago, Chicago, Illinois, USA
Correspondence
Narutoshi Hibino, Section of Cardiac Surgery, Department of Surgery, The University of Chicago, 5841 S. Maryland Ave, Room E500B | MC5040 Chicago, IL 60637, USA.
Email: [email protected]
Search for more papers by this authorTakuma Fukunishi
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorCecillia Lui
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorChin Siang Ong
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorTyler Dunn
Section of Cardiac Surgery, University of Chicago, Chicago, Illinois, USA
Search for more papers by this authorShanxiu Xu
Section of Cardiac Surgery, University of Chicago, Chicago, Illinois, USA
Search for more papers by this authorCarissa Smoot
The Secant Group, LLC, Telford, Pennsylvania, USA
Search for more papers by this authorJeremy Harris
The Secant Group, LLC, Telford, Pennsylvania, USA
Search for more papers by this authorPeter Gabriele
The Secant Group, LLC, Telford, Pennsylvania, USA
Search for more papers by this authorLakshmi Santhanam
Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, Maryland, USA
Search for more papers by this authorCorresponding Author
Narutoshi Hibino
Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Section of Cardiac Surgery, University of Chicago, Chicago, Illinois, USA
Correspondence
Narutoshi Hibino, Section of Cardiac Surgery, Department of Surgery, The University of Chicago, 5841 S. Maryland Ave, Room E500B | MC5040 Chicago, IL 60637, USA.
Email: [email protected]
Search for more papers by this authorTakuma Fukunishi and Cecillia Lui contributed equally to this work.
Abstract
In the ongoing search for the optimal biomaterial for tissue engineered vascular grafts (TEVGs), poly (glycerol sebacate) (PGS) has emerged as a new potential candidate. We have utilized a novel method to create unique, pore-free, extruded PGS grafts with and without a supportive exterior layer of polyglycolic acid (PGA). The 1 mm diameter by 5 mm length TEVGs were implanted in a rat model of infrarenal abdominal aorta interposition grafting. Three months after implantation, TEVGs comprised of extruded PGS with an external PGA braid demonstrated a patency rate of 9/10 (90%) with no signs of dilatation, dehiscence, or rupture. The PGS/PGA graft was remodeled into a neoartery with complete endothelialization of the neoartery lumen and formation of smooth muscle actinin multilayers as demonstrated via immunohistochemistry. Formation and maturation of extracellular matrix material were also observed, with amounts of elastin and collagen comparable to native rat aorta. No significant host inflammatory response was observed. These findings suggest the combination of an extruded PGS tube with an external reinforcing PGA braid is a promising material for small diameter TEVGs.
CONFLICT OF INTEREST
The authors have declared that there is no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| term3282-sup-0001-fig_s1.pdf868.2 KB | Supporting Information 1 |
| term3282-sup-0002-fig_s2.pdf1.1 MB | Supporting Information 2 |
| term3282-sup-0003-fig_s3.pdf910.7 KB | Supporting Information 3 |
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