A phlorotannins-loaded homogeneous acellular matrix film modulates post-implantation inflammatory responses
Tae-Hee Kim
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Search for more papers by this authorSeong-Yeong Heo
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Jeju Marine Research Center, Korea Institute of Ocean Science & Technology (KIOST), Jeju, Korea
Search for more papers by this authorGun-Woo Oh
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Search for more papers by this authorWon Sun Park
Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea
Search for more papers by this authorIl-Whan Choi
Department of Microbiology, College of Medicine, Inje University, Busan, Korea
Search for more papers by this authorHyun Wook Kang
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Search for more papers by this authorHyun-Woo Kim
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Department of Marine Biology, Pukyong National University, Busan, Korea
Search for more papers by this authorYoung-Mog Kim
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Department of Food Science and Technology, Pukyong National University, Busan, Korea
Search for more papers by this authorSung-Han Jo
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Search for more papers by this authorSang-Hyug Park
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Search for more papers by this authorCorresponding Author
Won-Kyo Jung
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Correspondence
Won-Kyo Jung, Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea.
Email: [email protected]
Search for more papers by this authorTae-Hee Kim
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Search for more papers by this authorSeong-Yeong Heo
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Jeju Marine Research Center, Korea Institute of Ocean Science & Technology (KIOST), Jeju, Korea
Search for more papers by this authorGun-Woo Oh
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Search for more papers by this authorWon Sun Park
Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea
Search for more papers by this authorIl-Whan Choi
Department of Microbiology, College of Medicine, Inje University, Busan, Korea
Search for more papers by this authorHyun Wook Kang
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Search for more papers by this authorHyun-Woo Kim
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Department of Marine Biology, Pukyong National University, Busan, Korea
Search for more papers by this authorYoung-Mog Kim
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Department of Food Science and Technology, Pukyong National University, Busan, Korea
Search for more papers by this authorSung-Han Jo
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Search for more papers by this authorSang-Hyug Park
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Search for more papers by this authorCorresponding Author
Won-Kyo Jung
Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, Korea
Research Center for Marine-Integrated Bionics Technology and Marine Integrated Biomedical Technology Center, Pukyong National University, Busan, Korea
Correspondence
Won-Kyo Jung, Department of Biomedical Engineering and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea.
Email: [email protected]
Search for more papers by this authorAbstract
Peritendinous adhesion mainly occurs between proliferating fibrous tissues and adjacent normal organs after surgery. Many physical barriers are applied to the implanted site to prevent peritendinous adhesion. However, these barriers often trigger inflammatory responses. Therefore, our study sought to develop phlorotannins-loaded cartilage acellular matrix (CAM) films as a physical barrier and investigate their inhibitory effect on inflammatory responses, which are associated with the induction of postoperative peritendinous adhesion (PAA). Our findings indicated that incorporating phlorotannin into the CAM film did not affect its unique characteristics including its thermal and spectroscopic properties. Moreover, the phlorotannins-loaded CAM films suppressed the expression of inflammatory mediators on RAW 264.7 macrophages stimulated using Escherichia coli lipopolysaccharides and exhibited an anti-inflammatory effect when implanted subcutaneously in rats. Therefore, our results highlight the potential of phlorotannins-loaded CAM films as a promising physical barrier to prevent PAA.
CONFLICT OF INTERST
The authors declare that there are no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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