REVIEW
A review of diabetic wound models—Novel insights into diabetic foot ulcer
Correction(s) for this article
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Corrigendum
- Volume 16Issue 9Journal of Tissue Engineering and Regenerative Medicine
- pages: 850-850
- First Published online: September 1, 2022
Shou Jin Phang,
Bavani Arumugam,
Umah Rani Kuppusamy,
Mh Busra Fauzi,
Mee Lee Looi,
Shou Jin Phang
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Search for more papers by this authorBavani Arumugam
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Search for more papers by this authorUmah Rani Kuppusamy
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Search for more papers by this authorMh Busra Fauzi
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Search for more papers by this authorCorresponding Author
Mee Lee Looi
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Correspondence
Mee Lee Looi, Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Email: [email protected]
Search for more papers by this authorShou Jin Phang,
Bavani Arumugam,
Umah Rani Kuppusamy,
Mh Busra Fauzi,
Mee Lee Looi,
Shou Jin Phang
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Search for more papers by this authorBavani Arumugam
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Search for more papers by this authorUmah Rani Kuppusamy
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Search for more papers by this authorMh Busra Fauzi
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Search for more papers by this authorCorresponding Author
Mee Lee Looi
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Correspondence
Mee Lee Looi, Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Email: [email protected]
Search for more papers by this authorAbstract
Diabetic foot ulcer (DFU) is a major debilitating complication of diabetes. Many research investigations have been conducted with the aims to uncover the diabetic wound healing mechanisms, develop novel therapeutics, and screen bioactive wound dressings in order to improve the current management of DFU. These would have not been possible without the utilization of an appropriate wound model, especially in a diabetic wound context. This review focuses on the different in vitro research models used in DFU investigations such as the 2D scratch wound assay, 3D skin model, and 3D angiogenesis model as well as their limitations. The current efforts and challenges to apply the 2D and 3D in vitro models in a hyperglycemic context to provide insights into DFU modeling will be reviewed. Perspectives of utilizing 3D bioprinting and skin-on-the-chip model as a diabetic wound model in the future will also be highlighted. By leveraging knowledge from past experiences and current research, an improved experimental model for DFU is anticipated to be established in near future.
CONFLICT OF INTEREST
The authors hereby declare that they have no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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