3D bioprinting of an electroactive and self-healing polysaccharide hydrogels
Yu-Long Wang
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorCorresponding Author
Lu Han
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Correspondence
Lu Han, The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing 102600, China.
Email: [email protected]
Yen Wei, Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China.
Email: [email protected]
Search for more papers by this authorXin-Lin Zhang
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorLong Cao
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorKun Hu
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorLu-Hai Li
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorCorresponding Author
Yen Wei
Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China
Correspondence
Lu Han, The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing 102600, China.
Email: [email protected]
Yen Wei, Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China.
Email: [email protected]
Search for more papers by this authorYu-Long Wang
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorCorresponding Author
Lu Han
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Correspondence
Lu Han, The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing 102600, China.
Email: [email protected]
Yen Wei, Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China.
Email: [email protected]
Search for more papers by this authorXin-Lin Zhang
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorLong Cao
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorKun Hu
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorLu-Hai Li
The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing, China
Search for more papers by this authorCorresponding Author
Yen Wei
Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China
Correspondence
Lu Han, The Engineering Research Center of 3D Printing and Bio-fabrication, Beijing Institute of Graphic Communication, Beijing 102600, China.
Email: [email protected]
Yen Wei, Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China.
Email: [email protected]
Search for more papers by this authorAbstract
Polysaccharide hydrogels including alginate, agarose, hyaluronic acid, and chitosan have been widely used as scaffolds in 3D bio-printing field. Konjac glucomannan (KGM) exhibits excellent properties of water solubility, biocompatibility, and biodegradability. Herein composite hydrogels were prepared via Schiff-base reaction between the aldehyde group of oxidized konjac glucomannan (OKGM) and the amino group of branched polyethyleneimine (PEI). The OKGM/PEI composite hydrogel displayed self-healing ability and pH sensitivity and showed shear thinning capability, which is suitable for 3D bio-printing technology. Furthermore, the OKGM/PEI electroactive composite hydrogel was obtained by adding carbon nanotubes (CNTs). Then the rheological behavior and morphology of OKGM/PEI electroactive hydrogels were thoroughly characterized. The conductivities of OKGM/PEI electroactive composite hydrogels increased with increasing the content of CNTs. The rheological behavior and 3D bio-printability of OKGM/PEI electroactive hydrogels were also tested. It was found that CNTs can also improve the bio-printability of OKGM/PEI electroactive hydrogels. Thus, the OKGM/PEI electroactive hydrogels could be employed as scaffolds for muscle and cardiac nerve tissue regeneration.
CONFLICT OF INTERESTS
The authors have declared that there is no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
Supporting Information
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| term3238-sup-0001-suppl-data.doc6.4 MB | Supporting Information S1 |
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