Limited research has been carried out to investigate the local damage features of reinforced concrete (RC) beams under close-in explosions. To better capture the local damage features of rectangular cross-sectional RC beams, a numerical study on the RC beams subjected to close-in explosions based on the calibrated Karagozian & Case (K&C) concrete model was conducted in LSDYNA. First, a systematic calibration of the K&C model for concrete was performed in the single-element numerical analysis. Calibration of the K&C model consists of parameter determination for the new strength surfaces, modification of the damage function to better feature the tensile behavior of concrete, elimination of the element size effect by introducing an element size factor and determination of the scaled damage factors. The new strength surfaces are verified and determined through both the approximation calculation method and the parameter fitting method. And the damage function was modified by reducing the termination of λ to better characterize the brittleness of concrete and feature the tensile failure. A comparison between the numerical results and the corresponding experimental results demonstrates that the calibrated K&C model and established FEM model of RC beams subjected to close-in explosions can well characterize the local damage features of RC beams. On this basis, a further parameter analysis on the factors influencing the local damage response of RC beams was conducted by considering reinforcement details (stirrup spacing and longitudinal reinforcement diameter) and charge details (charge mass and aspect ratio). Results show that the close-in explosions destroyed the concrete corners in the blast surface with shear stress first and the side shear failure of concrete corners weakens the concrete core strength and contributes to the greater loss of concrete core. Rear spalling damage was initially caused by the bond failure between the tensile longitudinal reinforcement and the surrounding concrete. Furthermore, increasing stirrup spacing, tensile longitudinal reinforcement diameter, and charge mass contribute to the increase in local damage sizes.