Review
Intelligent Nanomaterials Design for Osteoarthritis Managements
Zhihao Chen,
Xuan Zheng,
Zhengzhi Mu,
Weijie Lu,
Haiyuan Zhang,
Jiao Yan,
Zhihao Chen
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorXuan Zheng
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorZhengzhi Mu
Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130022 China
Search for more papers by this authorWeijie Lu
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
Department of Orthopedics, Yanjiang Hospital, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorHaiyuan Zhang
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorCorresponding Author
Jiao Yan
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
E-mail: [email protected]
Search for more papers by this authorZhihao Chen,
Xuan Zheng,
Zhengzhi Mu,
Weijie Lu,
Haiyuan Zhang,
Jiao Yan,
Zhihao Chen
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorXuan Zheng
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorZhengzhi Mu
Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130022 China
Search for more papers by this authorWeijie Lu
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
Department of Orthopedics, Yanjiang Hospital, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorHaiyuan Zhang
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
Search for more papers by this authorCorresponding Author
Jiao Yan
The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511436 China
School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436 China
E-mail: [email protected]
Search for more papers by this authorAbstract
Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive joint degradation, pain, and diminished mobility, all of which collectively impair patients’ quality of life and escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, and temporary symptom relief, underscoring the urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials and nanomedicines offer promising solutions by improving drug bioavailability, reducing side effects and providing targeted therapeutic benefits. This review critically examines the pathogenesis of OA, highlights the limitations of existing treatments, and explores the latest innovations in intelligent nanomaterials design for OA therapy, with an emphasis on their engineered properties, therapeutic mechanisms, and translational potential in clinical application. By compiling recent findings, this work aims to inspire further exploration and innovation in nanomedicine, ultimately advancing the development of more effective and personalized OA therapies.
Conflict of Interest
The authors declare that they have no competing interests.
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