Review
Breaking Barriers in Oncology: Harnessing Sonodynamic Therapy for Enhanced Tumor Metabolism Regulation
Yangmengfan Chen,
Kun Li,
Hao Du,
Yangcheng Yao,
Dong Xie,
Zongke Zhou,
Yangmengfan Chen
Department of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorKun Li
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433 China
Search for more papers by this authorHao Du
Department of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Yangcheng Yao
Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, 511400 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Dong Xie
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zongke Zhou
Department of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorYangmengfan Chen,
Kun Li,
Hao Du,
Yangcheng Yao,
Dong Xie,
Zongke Zhou,
Yangmengfan Chen
Department of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorKun Li
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433 China
Search for more papers by this authorHao Du
Department of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Yangcheng Yao
Center for Reproductive Medicine, Guangdong Women and Children Hospital, Guangzhou, 511400 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Dong Xie
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zongke Zhou
Department of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
The recent booming development of sonometabolism regulation in controlling the tumor microenvironment (TME) has opened a new research area to identify innovative approaches against cancer. The aim of this review is to highlight the potentials and advantages of sonodynamic therapy (SDT) in antitumor nanotherapies, specifically, delineating the progress made in SDT concerning the regulation of TME metabolism which encompasses factors such as hypoxia, redox balance, autophagy, immunosuppression, ion homeostasis, and other metabolic processes. By focusing on both tumor cell metabolism and TME dynamics, a wide range of SDT strategies that have demonstrated great therapeutic effectiveness by targeting the metabolic functions inherent to TME are summarized. In conclusion, this review offers valuable insights for researchers involved in SDT-based antitumor therapeutic strategies, with the aim of advancing the development of antitumor SDT methodologies in future research.
Conflict of Interest
The authors declare no conflict of interest.
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