Liver-on-a-Chip: Bioengineered Multicellular Liver Microtissues for Modeling Advanced Hepatic Fibrosis Driven Through Non-Alcoholic Fatty Liver Disease (Small 14/2021)
Hyun-Jong Cho
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon, 24341 Republic of Korea
Search for more papers by this authorHan-Jun Kim
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorKangJu Lee
Department of Healthcare Medical Engineering, Chonnam National University, Yeosu, 59626 Republic of Korea
Search for more papers by this authorSoufian Lasli
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorAly Ung
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorTyler Hoffman
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorRohollah Nasiri
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorPraveen Bandaru
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorSamad Ahadian
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorMehmet R. Dokmeci
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorJunmin Lee
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorAli Khademhosseini
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, 90095 USA
Search for more papers by this authorHyun-Jong Cho
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon, 24341 Republic of Korea
Search for more papers by this authorHan-Jun Kim
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorKangJu Lee
Department of Healthcare Medical Engineering, Chonnam National University, Yeosu, 59626 Republic of Korea
Search for more papers by this authorSoufian Lasli
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorAly Ung
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorTyler Hoffman
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorRohollah Nasiri
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorPraveen Bandaru
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorSamad Ahadian
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorMehmet R. Dokmeci
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Search for more papers by this authorJunmin Lee
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Search for more papers by this authorAli Khademhosseini
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095 USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA
Department of Radiological Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095 USA
Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, 90095 USA
Search for more papers by this authorGraphical Abstract
In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular liver microtissues and a liver-on-a-chip system. The microtissues consisting of four major liver cell types (primary human hepatocytes, stellate cells, Kupffer cells, and endothelial cells) recapitulate the pathogenesis of hepatic fibrosis driven by NAFLD.
