Review
Functional Extracellular Vesicles for Regenerative Medicine
Han Young Kim,
Seunglee Kwon,
Wooram Um,
Sol Shin,
Chan Ho Kim,
Jae Hyung Park,
Byung-Soo Kim,
Han Young Kim
Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662 Republic of Korea
Search for more papers by this authorSeunglee Kwon
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Search for more papers by this authorWooram Um
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Search for more papers by this authorSol Shin
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351 Republic of Korea
Search for more papers by this authorChan Ho Kim
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Search for more papers by this authorCorresponding Author
Jae Hyung Park
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351 Republic of Korea
Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419 Republic of Korea
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Byung-Soo Kim
School of Chemical and Biological Engineering, Interdisciplinary Program of Bioengineering, Institute of Chemical Processes, Institute of Engineering Research, BioMAX, Seoul National University, Seoul, 08826 Republic of Korea
E-mail: [email protected]; [email protected]
Search for more papers by this authorHan Young Kim,
Seunglee Kwon,
Wooram Um,
Sol Shin,
Chan Ho Kim,
Jae Hyung Park,
Byung-Soo Kim,
Han Young Kim
Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662 Republic of Korea
Search for more papers by this authorSeunglee Kwon
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Search for more papers by this authorWooram Um
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Search for more papers by this authorSol Shin
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351 Republic of Korea
Search for more papers by this authorChan Ho Kim
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Search for more papers by this authorCorresponding Author
Jae Hyung Park
School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351 Republic of Korea
Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419 Republic of Korea
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Byung-Soo Kim
School of Chemical and Biological Engineering, Interdisciplinary Program of Bioengineering, Institute of Chemical Processes, Institute of Engineering Research, BioMAX, Seoul National University, Seoul, 08826 Republic of Korea
E-mail: [email protected]; [email protected]
Search for more papers by this authorAbstract
The unique biological characteristics and promising clinical potential of extracellular vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as important mediators of intercellular communication, naturally secreted EVs have the potential, as innate biotherapeutics, to promote tissue regeneration. Although EVs have emerged as novel therapeutic agents, challenges related to the clinical transition have led to further functionalization. In recent years, various engineering approaches such as preconditioning, drug loading, and surface modification have been developed to potentiate the therapeutic outcomes of EVs. Also, limitations of natural EVs have been addressed by the development of artificial EVs that offer advantages in terms of production yield and isolation methodologies. In this review, an updated overview of current techniques is provided for the functionalization of natural EVs and recent advances in artificial EVs, particularly in the scope of regenerative medicine.
Conflict of Interest
The authors declare no conflict of interest.
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