Destruction and Control of Toxoplasma gondii Tachyzoites Using Gold Nanosphere/Antibody Conjugates†
Dakrong Pissuwan
Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
Search for more papers by this authorStella M. Valenzuela
Department of Molecular and Bioscience University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
Search for more papers by this authorCatherine M. Miller
Institute for the Biotechnology of Infectious Disease University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007, (Australia)
Search for more papers by this authorMurray C. Killingsworth
Sydney South West Pathology Service Locked Bag 7090 Liverpool BC, NSW, 1871 (Australia)
Search for more papers by this authorCorresponding Author
Michael B. Cortie
Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia).Search for more papers by this authorDakrong Pissuwan
Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
Search for more papers by this authorStella M. Valenzuela
Department of Molecular and Bioscience University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
Search for more papers by this authorCatherine M. Miller
Institute for the Biotechnology of Infectious Disease University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007, (Australia)
Search for more papers by this authorMurray C. Killingsworth
Sydney South West Pathology Service Locked Bag 7090 Liverpool BC, NSW, 1871 (Australia)
Search for more papers by this authorCorresponding Author
Michael B. Cortie
Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia).Search for more papers by this authorThis work was supported by the University of Technology Sydney. We thank Dr. Brian Reedy and Mr. Michael Lees for technical support.
Graphical Abstract
The protozoan parasite Toxoplasma gondii can be selectively targeted and photothermally destroyed by gold nanosphere/antibody conjugates (see image). The optical response of the nanospheres within the “tissue window” is shifted and enhanced by aggregation. Attachment of the conjugates alone, even without plasmonic heating, lowers the infectivity of the organism.
Supporting Information
Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
| Filename | Description |
|---|---|
| smll_200801018_sm_supplfigs.pdf332 KB | supplfigs |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1 D. Pissuwan, S. M. Valenzuela, M. B. Cortie, Trends Biotechnol. 2006, 24, 62– 67.
- 2 L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, J. L. West, Proc. Natl. Acad. Sci. USA 2003, 100, 13549– 13554.
- 3 D. P. O'Neal, L. R. Hirsch, N. J. Halas, J. D. Payne, J. L. West, Cancer Lett. 2004, 209, 171– 176.
- 4 I. H. El-Sayed, X. Huang, M. A. El-Sayed, Cancer Lett. 2006, 239, 129– 135.
- 5 D. Lapotko, E. Lukianova, O. Aleinikova, A. Oraevsky, Cancer Lett. 2006, 239, 36– 45.
- 6 V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, M. S. Smeltzer, Biophys. J. 2006, 90, 619– 627.
- 7 D. Pissuwan, S. M. Valenzuela, M. C. Killingsworth, X. D. Xu, M. B. Cortie, J. Nanopart. Res. 2007, 9, 1109– 1124.
- 8 D. Pissuwan, S. Valenzuela, C. M. Miller, M. B. Cortie, Nano Lett. 2007, 7, 3808– 3812.
- 9 R. Elghanian, J. J. Storhoff, R. C. Mucic, R. L. Letsinger, C. A. Mirkin, Science 1997, 277, 1078– 1081.
- 10 V. P. Zharov, E. I. Galanzha, E. V. Shashkov, N. G. Khlebtsov, V. V. Tuchin, Opt. Lett. 2006, 31, 3623– 3625.
- 11 C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, R. Drezek, Technol. Cancer Res. 2004, T3, 33– 40.
- 12 X. Huang, I. H. El-Sayed, W. Qian, M. A. El-Sayed, J. Am. Chem. Soc. 2006, 128, 2115– 2120.
- 13 H. Takahashi, Y. Niidome, S. Yamada, Chem. Commun. 2005, 2247– 2249.
- 14 G. F. Paciotti, L. Myer, D. Weinreich, D. Goia, N. Pavel, R. E. McLaughlin, L. Tamarkin, Drug Delivery 2004, 11, 169– 183.
- 15 F. A. Jolesz, K. Hynynen, Cancer J. 2002, 8, S100– S112.
- 16 D. Pissuwan, C. H. Cortie, S. Valenzuela, M. B. Cortie, Gold Bull. 2007, 40, 121– 129.
- 17 J. Alibertie, Nat. Rev. Immunol. 2005, 5, 162– 170.
- 18 A. Tenter, A. R. Heckeroth, L. M. Weiss, Int. J. Parasitol. 2000, 30, 1217– 1258.
- 19 J. G. Montoya, O. Liesenfeld, Lancet 2004, 363, 1965– 1976.
- 20 C. R. Simpson, M. Kohl, M. Essenpreis, M. Copey, Phys. Med. Biol. 1998, 43, 2465– 2478.
- 21 V. P. Zharov, E. N. Galitovskaya, C. Johnson, T. Kelly, Lasers Surg. Med. 2005, 37, 219– 226.
- 22 J. Grimwood, J. E. Smith, Exp. Parasitol. 1992, 74, 106– 111.
- 23 F. Velge-Roussel, I. Dimier-Poisson, D. Buzon-Gater, D. Bout, Parasitology 2001, 123, 225– 233.
- 24 J. W. Slot, H. J. Geuze, Eur. J. Cell Biol. 1985, 38, 87– 93.
- 25 S. H. Brewer, W. R. Glomm, M. C. Johnson, M. K. Knag, S. Franzen, Langmuir 2005, 21, 9303– 9307.
- 26 R. Evans, J. M. W. Chatterton, D. Ashburn, A. W. L. Joss, D. O. Ho-Yen, Eur. J. Clin. Microbiol. Infect. Dis. 1999, 18, 879– 884.
- 27 D. B. Woodmansee, J. Parasitol. 2003, 89, 895– 898.
- 28 B. T. Draine, P. J. Flatau, J. Opt. Soc. Am. A 1994, 11, 1491– 1499.
