Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama)
A. L. da Silva
Curso de Pós Graduação em Ciências Biológicas-Bioquímica, Universidade Federaldo Rio Grande do Sul, Av. Ramiro Barcelos 2600, 90035-003, Porto Alegre, RS, Brazil
Search for more papers by this authorS. Bardini
Laboratório de Etnofarmacologia, ICBS, Universidade Federal do Rio Grande do Sul, Av. Sarmento Leite 500/202, 90046-900, Porto Alegre, RS, Brazil
Search for more papers by this authorD. S. Nunes
Departamento de Química, Universidade Estadual de Ponta Grossa, Campus Uvaranas, Bloco M, 84030-310, Ponta Grossa, PR, Brazil
Search for more papers by this authorCorresponding Author
E. Elisabetsky
Curso de Pós Graduação em Ciências Biológicas-Bioquímica, Universidade Federaldo Rio Grande do Sul, Av. Ramiro Barcelos 2600, 90035-003, Porto Alegre, RS, Brazil
Laboratório de Etnofarmacologia, ICBS, Universidade Federal do Rio Grande do Sul, Av. Sarmento Leite 500/202, 90046-900, Porto Alegre, RS, Brazil
CP 5072, 90041-970, Porto Alegre, RS, BrazilSearch for more papers by this authorA. L. da Silva
Curso de Pós Graduação em Ciências Biológicas-Bioquímica, Universidade Federaldo Rio Grande do Sul, Av. Ramiro Barcelos 2600, 90035-003, Porto Alegre, RS, Brazil
Search for more papers by this authorS. Bardini
Laboratório de Etnofarmacologia, ICBS, Universidade Federal do Rio Grande do Sul, Av. Sarmento Leite 500/202, 90046-900, Porto Alegre, RS, Brazil
Search for more papers by this authorD. S. Nunes
Departamento de Química, Universidade Estadual de Ponta Grossa, Campus Uvaranas, Bloco M, 84030-310, Ponta Grossa, PR, Brazil
Search for more papers by this authorCorresponding Author
E. Elisabetsky
Curso de Pós Graduação em Ciências Biológicas-Bioquímica, Universidade Federaldo Rio Grande do Sul, Av. Ramiro Barcelos 2600, 90035-003, Porto Alegre, RS, Brazil
Laboratório de Etnofarmacologia, ICBS, Universidade Federal do Rio Grande do Sul, Av. Sarmento Leite 500/202, 90046-900, Porto Alegre, RS, Brazil
CP 5072, 90041-970, Porto Alegre, RS, BrazilSearch for more papers by this authorAbstract
Alcohol infusions of roots of Ptychopetalum olacoides Benth. (PO), known as Marapuama or Muirapuama, are used in the Brazilian Amazon as a ‘nerve tonic’. Over the years PO has been found increasingly in phytoformulations and regarded as a stimulant, claimed to enhance physical and mental performances. This study determined that a P. olacoides ethanol extract (30, 100 and 300mg/kg) decreased exploratory behaviour in the hole-board test, without interfering with locomotion or motor coordination (rota-rod test). The data are comparable to that obtained with pentylenetetrazol (40 mg/kg), suggesting an anxiogenic effect of P. olacoides. Copyright © 2002 John Wiley & Sons, Ltd.
References
- Bhattacharya SK, Mitra SK. 1991. Anxiolytic activity of Panax ginseng roots: an experimental study. J Ethnopharm 34: 87–92.
- Dalmmeier K, Carlini EA. 1981. Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology 22: 113–127.
- Dalvi A, Rodgers RJ. 1999. Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance. Pharm Biochem Behav 62 (4): 727–734.
- De Angelis L, Bertolissi M, Nardini G, Traversa U, Vertua R. 1982. Interaction of caffeine with benzodiazepines: behavior effects in mice. Arch Int Pharmacodyn 255: 89–102.
- Durcan MJ, Lister RG. 1988. Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice. Psychopharmacology 96: 67–72.
- Elisabetsky E. 1987. From indigenous disease concepts to laboratory work hypothesis: the case of ‘nerve tonics’ from the Brazilian Amazon. International Foundation for Science, Provisional Report Series, 84–100.
- Elisabetsky E, Figueiredo W, Oliveira G. 1992. Traditional Amazonian nerve tonics as antidepressant agents: Chaunochiton kappleri: a case study. J Herbs Spices Med Plants 1: 125–161.
10.1300/J044v01n01_11 Google Scholar
- Elisabetsky E, Siqueira IR. 1998. Is there a psychopharmacological meaning for traditional tonics? In Plants for Food and Medicine, HDV Prendergast, NL Etkin, DR Harris, PJ Houghton (eds). Royal Botanic Gardens: Kew; 372–385.
- File SE. 1987a. The contribution of behavioural studies to the neuropharmacology of anxiety. Neuropharmacology 26 (7B): 877–886.
- File SE. 1987b. Beyond the benzodiazepines : search for new anxiolytics. Human Psychopharmacol 2: 151–158.
- File SE, Wardill GA. 1975. Validity of head-dipping as a measure of exploration in a modified hole-board. Psychopharmacologia (Berl.) 44: 53–59.
- Jaffe JH. 1990. Drug addition and drug abuse. In The Pharmacological Basis of Therapeutics, AG Gilman, TW Rall, AS Nies, P Taylor (eds). Pergamon Press: Oxford; 522–573.
- Grenand P, Moretti C, Jacquemin H. 1987. Pharmacopées Traditiomelles en Guyane, 1st edn. Editions de L'Or stom: France; 326–328.
- Kennedy B. 1978. Experimental approaches to the detection of anxiolytic activity in the rat. Irish J Med Sci 147 (1): 38–42.
- Moreira EG, Nascimento N, Rosa GJM, Rogero JR, Vassilieff VS. 1996. Crotoxin-induced behavioral effects in rats. Braz J Med Biol Res 29: 629–632.
- Paiva LAF, Rao VSN, Silveira ER. 1998. Effects of Ptychopetalum olacoides extract on mouse behavior in forced swimming and open field test. Phytother Res 12: 294–296.
- Ramanathan M, Jaiswal AK, Bhattacharya SK. 1998. Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats. Psychopharmacology 135: 361–367.
- Rodgers RJ, Cole JC, Aboualfa K, Stephenson LH. 1995. Ethopharmacological analysis of the effects of putative ‘anxiogenic’ agents in the mouse elevated plus-maze. Pharmacol Biochem Behav 52: 805–813.
- Siqueira IR, Lara DR, Gaieski FS, Nunes, DS, Elisabetsky E. 1998. Psychopharmacology proprieties of Ptychopetalum olacoides Bentham (Olacaceae). Pharm Biol 36: 327–334.
- Takeda H, Tsuji M, Matsumiya T. 1998. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur J Pharmacol 350: 21–29.
- Treit D. 1985. Animal models for the study of anti-anxiety agents: a review. Neurosci Biobehav Rev 9: 203–222.
- Uber Bucek E, Fournier G, Dadoun H. 1987. Volatile constituents of Ptychopetalum olacoides root oil. Planta Med 53: 231.
- Wieland S, Lan NC, Mirasedeghi S, Gee KW. 1991. Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res 565: 263–268.
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