REVIEW
Phytotherapeutics in cancer invasion and metastasis
Bahare Salehi,
Paolo Zucca,
Mehdi Sharifi-Rad,
Raffaele Pezzani,
Sadegh Rajabi,
William N. Setzer,
Elena Maria Varoni,
Marcello Iriti,
Farzad Kobarfard,
Javad Sharifi-Rad,
Bahare Salehi
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Search for more papers by this authorPaolo Zucca
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Search for more papers by this authorCorresponding Author
Mehdi Sharifi-Rad
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol, 61663-335 Iran
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Raffaele Pezzani
OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova, 35128 Italy
AIROB, Associazione Italiana per la Ricerca Oncologica di Base, Padova, Italy
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorSadegh Rajabi
Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Search for more papers by this authorWilliam N. Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899 USA
Search for more papers by this authorElena Maria Varoni
Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy
Search for more papers by this authorCorresponding Author
Marcello Iriti
Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorFarzad Kobarfard
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
Javad Sharifi-Rad
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, Canada
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorBahare Salehi,
Paolo Zucca,
Mehdi Sharifi-Rad,
Raffaele Pezzani,
Sadegh Rajabi,
William N. Setzer,
Elena Maria Varoni,
Marcello Iriti,
Farzad Kobarfard,
Javad Sharifi-Rad,
Bahare Salehi
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Search for more papers by this authorPaolo Zucca
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Search for more papers by this authorCorresponding Author
Mehdi Sharifi-Rad
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol, 61663-335 Iran
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Raffaele Pezzani
OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova, 35128 Italy
AIROB, Associazione Italiana per la Ricerca Oncologica di Base, Padova, Italy
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorSadegh Rajabi
Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Search for more papers by this authorWilliam N. Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899 USA
Search for more papers by this authorElena Maria Varoni
Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy
Search for more papers by this authorCorresponding Author
Marcello Iriti
Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorFarzad Kobarfard
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
Javad Sharifi-Rad
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, Canada
Correspondence
Mehdi Sharifi-Rad, Department of Medical Parasitology, Zabol University Of Medical Sciences, Zabol 61663-335, Iran.
Email: [email protected]
Raffaele Pezzani, OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, Padova 35128, Italy.
Email: [email protected]
Marcello Iriti, Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy.
Email: [email protected]
Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorAbstract
Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.
CONFLICT OF INTEREST
The authors declare that there is no conflict of interest.
REFERENCES
- Abdel-Latif, G. A., Al-Abd, A. M., Tadros, M. G., Al-Abbasi, F. A., Khalifa, A. E., & Abdel-Naim, A. B. (2015). The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Scientific Reports, 5, 12054.
- Abdelmageed, M. M., El-Naga, R. N., El-Demerdash, E., & Elmazar, M. M. (2016). Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study. Scientific Reports, 6, 32733.
- Ahn, W. S., Yoo, J., Huh, S. W., Kim, C. K., Lee, J. M., Namkoong, S. E., … Lee, I. P. (2003). Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 12(5), 383–390.
- Ahn-Jarvis, J. H., Clinton, S. K., Grainger, E. M., Riedl, K. M., Schwartz, S. J., Lee, M. L. T., … Vodovotz, Y. (2015). Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer. Cancer Prevention Research, 8(11), 1045–1054.
- Alberts, B, Johnson, A, Lewis, J, Raff, M, Roberts, K, Walter, P. 1997. Molecular biology of the cell (Garland Science, New York, 2002). There is no corresponding record for this reference.
- Aldaz, C. M., Conti, C. J., Klein-Szanto, A., & Slaga, T. J. (1987). Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proceedings of the National Academy of Sciences, 84(7), 2029–2032.
- Allegra, A., Innao, V., Russo, S., Gerace, D., Alonci, A., & Musolino, C. (2017). Anticancer activity of curcumin and its analogues: Preclinical and clinical studies. Cancer Investigation, 35(1), 1–22.
- American_Cancer_Society, 2017. Cancer Facts and Statistics.
- Amin, A. R., Khuri, F. R., Chen, Z. G., & Shin, D. M. (2009). Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erlotinib and epigallocatechin-3-gallate: The role of p53-dependent inhibition of nuclear factor-kappaB. Cancer Prevention Research (Philadelphia, Pa.), 2(6), 538–545.
- Ansari, M. S., & Gupta, N. P. (2004). A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. Erratum In: BJU Int 2004, 93, 655.
- Azevedo, A. S., Follain, G., Patthabhiraman, S., Harlepp, S., & Goetz, J. G. (2015). Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both? Cell Adhesion & Migration, 9(5), 345–356.
- Azzoli, C. G., Miller, V. A., Ng, K. K., Krug, L. M., Spriggs, D. R., Tong, W. P., … Kris, M. G. (2003). A phase I trial of perillyl alcohol in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology, 51(6), 493–498.
- Bacac, M., & Stamenkovic, I. (2008). Metastatic cancer cell. Annu. Rev. pathmechdis. Mech. Dis., 3, 221–247.
- Bae, K., Park, J., Kim, J., Cho, C., Oh, B., Costa, D., & Yoo, H. S. (2017). Traditional oriental herbal medicine and natural killer cells for cancer patients: A systematic review and meta-analysis. Phytotherapy Research.
- Baena Ruiz, R., & Salinas Hernández, P. (2016). Cancer chemoprevention by dietary phytochemicals: Epidemiological evidence. Maturitas, 94, 13–19.
- Baeriswyl, V., & Christofori, G. (2009). The angiogenic switch in carcinogenesis, Seminars in cancer biology. Elsevier, pp., 329–337.
- Bagheri, G., Mirzaei, M., Mehrabi, R., & Sharifi-Rad, J. (2016). Cytotoxic and antioxidant activities of Alstonia scholaris, Alstonia venenata and Moringa oleifera plants from India. Jundishapur Journal of Natural Pharmaceutical Products, 11(3).
- Bailey, H. H., Attia, S., Love, R. R., Fass, T., Chappell, R., Tutsch, K., … Stewart, J. A. (2008). Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. Cancer Chemotherapy and Pharmacology, 62(1), 149–157.
- Balkwill, F., & Mantovani, A. (2001). Inflammation and cancer: Back to Virchow? The Lancet, 357(9255), 539–545.
- Barber, N. J., Zhang, X., Zhu, G., Pramanik, R., Barber, J. A., Martin, F. L., … Muir, G. H. (2006). Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer and Prostatic Diseases, 9(4), 407–413.
- Barbieri, R., Coppo, E., Marchese, A., Daglia, M., Sobarzo-Sánchez, E., Nabavi, S. F., & Nabavif, S. M. (2017). Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity. Microbiological Research, 196, 44–68.
- Bastin, J., & Djouadi, F. (2016). Resveratrol and myopathy. Nutrients, 8(5).
- Bauer, J. A., Ye, F., Marshall, C. B., Lehmann, B. D., Pendleton, C. S., Shyr, Y., & Pietenpol, J. A. (2010). RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells. Breast Cancer Research, 12(3), R41.
- Bekaii-Saab, T. S., & Villalona-Calero, M. A. (2005). Preclinical experience with docetaxel in gastrointestinal cancers. Seminars in Oncology, 32(2 Suppl 4), S3.
- Bell, B. A., Chang, M. N., & Weinstein, H. J. (2001). A phase II study of homoharringtonine for the treatment of children with refractory or recurrent acute myelogenous leukemia: A pediatric oncology group study. Medical and Pediatric Oncology, 37(2), 103–107.
- Bendas, G., & Borsig, L. (2012). Cancer cell adhesion and metastasis: Selectins, integrins, and the inhibitory potential of heparins. International journal of cell biology, 2012.
- Berenblum, I. (1954). A speculative review: The probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis. Cancer Research, 14(7), 471–477.
- Bergmann, L., Aamdal, S., Marreaud, S., Lacombe, D., Herold, M., Yamaguchi, T., … European Organisation for Research and Treatment of Cancer. (2008). Phase I trial of r viscumin (INN: aviscumine) given subcutaneously in patients with advanced cancer: A study of the European Organisation for Research and Treatment of Cancer (EORTC protocol number 13001). European Journal of Cancer, 44(12), 1657–1662.
- Bettuzzi, S., Brausi, M., Rizzi, F., Castagnetti, G., Peracchia, G., & Corti, A. (2006). Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study. Cancer Research, 66(2), 1234–1240.
- Bhardwaj, A., Sethi, G., Vadhan-Raj, S., Bueso-Ramos, C., Takada, Y., Gaur, U., … Aggarwal, B. B. (2007). Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood, 109(6), 2293–2302.
- Blazejczyk, A., Papiernik, D., Porshneva, K., Sadowska, J., & Wietrzyk, J. (2015). Endothelium and cancer metastasis: Perspectives for antimetastatic therapy. Pharmacological Reports, 67(4), 711–718.
- Bockhorn, M., Jain, R. K., & Munn, L. L. (2007). Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? The Lancet Oncology, 8(5), 444–448.
- Bonofiglio, D., Giordano, C., De Amicis, F., Lanzino, M., & Andò, S. (2016). Natural products as promising antitumoral agents in breast cancer: Mechanisms of action and molecular targets. Mini-Reviews in Medicinal Chemistry, 16(8), 596–604.
- Bos, P. D., Zhang, X. H.-F., Nadal, C., Shu, W., Gomis, R. R., Nguyen, D. X., … Massagué, J. (2009). Genes that mediate breast cancer metastasis to the brain. Nature, 459(7249), 1005–1009.
- Bunker, C. H., McDonald, A. C., Evans, R. W., De La Rosa, N., Boumosleh, J. M., & Patrick, A. L. (2007). A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk. Nutrition and Cancer, 57(2), 130–137.
- Bushunow, P., Reidenberg, M. M., Wasenko, J., Winfield, J., Lorenzo, B., Lemke, S., … Coyle, T. (1999). Gossypol treatment of recurrent adult malignant gliomas. Journal of Neuro-Oncology, 43(1), 79–86.
- Cai, Z., Wang, C., Liu, P., Shen, P., Han, Y., & Liu, N. (2016). Ginkgo biloba extract in combination with sorafenib is clinically safe and tolerable in advanced hepatocellular carcinoma patients. Phytomedicine, 23(12), 1295–1300.
- Cao, H., Wang, Y., He, X., Zhang, Z., Yin, Q., Chen, Y., … Li, Y. (2015). Codelivery of sorafenib and curcumin by directed self-assembled nanoparticles enhances therapeutic effect on hepatocellular carcinoma. Molecular Pharmaceutics, 12(3), 922–931.
- Cao, J., Han, J., Xiao, H., Qiao, J., & Han, M. (2016). Effect of tea polyphenol compounds on anticancer drugs in terms of anti-tumor activity, toxicology, and pharmacokinetics. Nutrients, 8(12).
- Caponigro, F., Longo, F., Perri, F., & Ionna, F. (2009). Docetaxel in the management of head and neck cancer. Anti-Cancer Drugs, 20(8), 639–645.
- Cassileth, B. R., Rizvi, N., Deng, G., Yeung, K. S., Vickers, A., Guillen, S., … Kris, M. G. (2009). Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients. Cancer Chemotherapy and Pharmacology, 65(1), 67–71.
- Catania, A., Barrajon-Catalan, E., Nicolosi, S., Cicirata, F., & Micol, V. (2013). Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells. Breast Cancer Research and Treatment, 141(1), 55–65.
- Chadalapaka, G., Jutooru, I., Burghardt, R., & Safe, S. (2010). Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular Cancer Research, 8(5), 739–750.
- Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., Li, X., & Safe, S. (2008). Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Research, 68(13), 5345–5354.
- Chambers, A., Groom, A., & MacDonald, I. (2002). ā€ Dissemination and growth of cancer cells in metastatic sites. ā€ Nat. Rev. Cancer, 2, 563ā.
- Chen, M., May, B. H., Zhou, I. W., Zhang, A. L., & Xue, C. C. (2016). Integrative medicine for relief of nausea and vomiting in the treatment of colorectal cancer using oxaliplatin-based chemotherapy: A systematic review and meta-analysis. Phytotherapy Research, 30(5), 741–753.
- Chiang, A. C., & Massagué, J. (2008). Molecular basis of metastasis. New England Journal of Medicine, 359(26), 2814–2823.
- Chiang, S. P., Cabrera, R. M., & Segall, J. E. (2016). Tumor cell intravasation. American Journal of Physiology-Cell Physiology, 311(1), C1–C14.
- Chimento, A., Sirianni, R., Saturnino, C., Caruso, A., Sinicropi, M. S., & Pezzi, V. (2016). Resveratrol and its analogs as antitumoral agents for breast cancer treatment. Mini-Reviews in Medicinal Chemistry, 16(9), 699–709.
- Chiu, L. Y., Hsin, I. L., Yang, T. Y., Sung, W. W., Chi, J. Y., Chang, J. T., … Sheu, G. T. (2017). The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Oncogene, 36(2), 242–253.
- Clinical_Trials, 2017.
- Cohen, S. M., Mukerji, R., Timmermann, B. N., Samadi, A. K., & Cohen, M. S. (2012). A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers. American Journal of Surgery, 204(6), 895–900. discussion 900-891
- Colomer, R., Sarrats, A., Lupu, R., & Puig, T. (2017). Natural polyphenols and their synthetic analogs as emerging anticancer agents. Current Drug Targets, 18(2), 147–159.
- Colon, J., Basha, M. R., Madero-Visbal, R., Konduri, S., Baker, C. H., Herrera, L. J., … Abdelrahim, M. (2011). Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Investigational New Drugs, 29(1), 41–51.
- Debata, P. R., Begum, S., Mata, A., Genzer, O., Kleiner, M. J., Banerjee, P., & Castellanos, M. R. (2013). Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O: Rapid inhibition of Rb phosphorylation as a preamble to cyclin D1 inhibition. Anti-Cancer Agents in Medicinal Chemistry, 13(10), 1508–1513.
- Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., … Kurzrock, R. (2008). Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical Cancer Research, 14(14), 4491–4499.
- Dillon, R. L., Chooniedass, S., Premsukh, A., Adams, G. P., Entwistle, J., MacDonald, G. C., & Cizeau, J. (2016). Trastuzumab-deBouganin conjugate overcomes multiple mechanisms of T-DM1 drug resistance. Journal of Immunotherapy, 39(3), 117–126.
- Du, G. J., Wang, C. Z., Zhang, Z. Y., Wen, X. D., Somogyi, J., Calway, T., … Yuan, C. S. (2012). Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. The Journal of Pharmacy and Pharmacology, 64(5), 727–734.
- Dua, R., Gui, G., & Isacke, C. (2005). Endothelial adhesion molecules in breast cancer invasion into the vascular and lymphatic systems. European Journal of Surgical Oncology (EJSO), 31(8), 824–832.
- Eghbaliferiz, S., & Iranshahi, M. (2016). Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: Updated review of mechanisms and catalyzing metals. Phytotherapy Research, 30(9), 1379–1391.
- Entschladen, F., Drell, T. L., Lang, K., Joseph, J., & Zaenker, K. S. (2004). Tumour-cell migration, invasion, and metastasis: Navigation by neurotransmitters. The Lancet Oncology, 5(4), 254–258.
- Farrell, M. P., & Kummar, S. (2003). Phase I/IIA randomized study of PHY906, a novel herbal agent, as a modulator of chemotherapy in patients with advanced colorectal cancer. Clinical Colorectal Cancer, 2(4), 253–256.
- Farzaei, M. H., Bahramsoltani, R., & Rahimi, R. (2016). Phytochemicals as adjunctive with conventional anticancer therapies. Current Pharmaceutical Design, 22(27), 4201–4218.
- Fischer, L., Mahoney, C., Jeffcoat, A. R., Koch, M. A., Thomas, B. F., Valentine, J. L., … Zeisel, S. H. (2004). Clinical characteristics and pharmacokinetics of purified soy isoflavones: Multiple-dose administration to men with prostate neoplasia. Nutrition and Cancer, 48(2), 160–170.
- Flaig, T. W., Glodé, M., Gustafson, D., Van Bokhoven, A., Tao, Y., Wilson, S., … Pollak, M. (2010). A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate, 70(8), 848–855.
- Flaig, T. W., Gustafson, D. L., Su, L. J., Zirrolli, J. A., Crighton, F., Harrison, G. S., … Glodé, L. M. (2007). A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Investigational New Drugs, 25(2), 139–146.
- Friedl, P., & Gilmour, D. (2009). Collective cell migration in morphogenesis, regeneration and cancer. Nature Reviews Molecular Cell Biology, 10(7), 445–457.
- Friedl, P., & Wolf, K. (2003). Tumour-cell invasion and migration: Diversity and escape mechanisms. Nature Reviews Cancer, 3(5), 362–374.
- Gandhy, S. U., Kim, K., Larsen, L., Rosengren, R. J., & Safe, S. (2012). Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. BMC Cancer, 12(1), 564.
- Gann, P. H., Deaton, R. J., Rueter, E. E., van Breemen, R. B., Nonn, L., Macias, V., … Ananthanarayanan, V. (2015). A phase II randomized trial of lycopene-rich tomato extract among men with high-grade prostatic intraepithelial neoplasia. Nutrition and Cancer, 67(7), 1104–1112.
- Gao, J. Z., Du, J. L., Wang, Y. L., Li, J., Wei, L. X., & Guo, M. Z. (2015). Synergistic effects of curcumin and bevacizumab on cell signaling pathways in hepatocellular carcinoma. Oncology Letters, 9(1), 295–299.
- Gao, Y., Jia, Z., Kong, X., Li, Q., Chang, D. Z., Wei, D., … Xie, K. (2011). Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Research, 71(15), 5182–5193.
- Garcea, G., Berry, D. P., Jones, D. J. L., Singh, R., Dennison, A. R., Farmer, P. B., … Gescher, A. J. (2005). Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiology Biomarkers and Prevention, 14(1), 120–125.
- Ge, J., Tan, B. X., Chen, Y., Yang, L., Peng, X. C., Li, H. Z., … Liu, J. Y. (2011). Interaction of green tea polyphenol epigallocatechin-3-gallate with sunitinib: Potential risk of diminished sunitinib bioavailability. Journal of Molecular Medicine, 89(6), 595–602.
- Golombick, T., Diamond, T. H., Manoharan, A., & Ramakrishna, R. (2012). Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: A randomized, double-blind placebo-controlled cross-over 4g study and an open-label 8g extension study. American Journal of Hematology, 87(5), 455–460.
- Gomes, F. G., Nedel, F., Alves, A. M., Nör, J. E., & Tarquinio, S. B. C. (2013). Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sciences, 92(2), 101–107.
- Gontero, P., Marra, G., Soria, F., Oderda, M., Zitella, A., Baratta, F., … Brusa, P. (2015). A randomized double-blind placebo controlled phase I-II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions. Chemoprevention or "chemopromotion"? Prostate, 75(11), 1177–1186.
- Gonzalez-Vallinas, M., Molina, S., Vicente, G., Sanchez-Martinez, R., Vargas, T., Garcia-Risco, M. R., … Ramírez de Molina, A. (2014). Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells. Electrophoresis, 35(11), 1719–1727.
- Granja, A., Pinheiro, M., & Reis, S. (2016). Epigallocatechin gallate nanodelivery systems for cancer therapy. Nutrients, 8(5).
- Gu, J., Ahn-Jarvis, J. H., Riedl, K. M., Schwartz, S. J., Clinton, S. K., & Vodovotz, Y. (2014). Characterization of black raspberry functional food products for cancer prevention human clinical trials. Journal of Agricultural and Food Chemistry, 62(18), 3997–4006.
- Hanahan, D., & Folkman, J. (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86(3), 353–364.
- He, Z. Y., Shi, C. B., Wen, H., Li, F. L., Wang, B. L., & Wang, J. (2011). Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investigation, 29(3), 208–213.
- Hedrick, E., Crose, L., Linardic, C. M., & Safe, S. (2015). Histone deacetylase inhibitors inhibit rhabdomyosarcoma by reactive oxygen species–dependent targeting of specificity protein transcription factors. Molecular Cancer Therapeutics, 14(9), 2143–2153.
- Hejmadi, M. 2009. Introduction to cancer biology. Bookboon.
- Hennings, H., Glick, A. B., Greenhalgh, D. A., Morgan, D. L., Strickland, J. E., Tennenbaum, T., & Yuspa, S. H. (1993). Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis. Experimental Biology and Medicine, 202(1), 1–8.
- Heppner, G. H., & Miller, F. R. (1997). The cellular basis of tumor progression. International Review of Cytology, 177, 1–56.
10.1016/S0074-7696(08)62230-5 Google Scholar
- Hernández-Almanza, A., Montañez, J., Martínez, G., Aguilar-Jiménez, A., Contreras-Esquivel, J. C., & Aguilar, C. N. (2016). Lycopene: Progress in microbial production. Trends in Food Science and Technology, 56, 142–148.
- Hillen, F., & Griffioen, A. W. (2007). Tumour vascularization: sprouting angiogenesis and beyond. Cancer and Metastasis Reviews, 26(3–4), 489–502.
- Holland-Frei (2003). Cancer medicine ( 6th ed.). Hamilton (ON): B.C. Decker Inc.
- Hong, S. H., Ismail, I. A., Kang, S. M., Han, D. C., & Kwon, B. M. (2016). Cinnamaldehydes in cancer chemotherapy. Phytotherapy Research, 30(5), 754–767.
- Hormann, V., Kumi-Diaka, J., Durity, M., & Rathinavelu, A. (2012). Anticancer activities of genistein-topotecan combination in prostate cancer cells. Journal of Cellular and Molecular Medicine, 16(11), 2631–2636.
- Hou, J.-M., Krebs, M. G., Lancashire, L., Sloane, R., Backen, A., Swain, R. K., … Dive, C. (2012). Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. Journal of Clinical Oncology, 30(5), 525–532.
- Howells, L. M., Berry, D. P., Elliott, P. J., Jacobson, E. W., Hoffmann, E., Hegarty, B., … Gescher, A. J. (2011). Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases—Safety, pharmacokinetics, and pharmacodynamics. Cancer Prevention Research (Philadelphia, Pa.), 4(9), 1419–1425.
- Hsin, I.-L., Sheu, G.-T., Chen, H.-H., Chiu, L.-Y., Wang, H.-D., Chan, H.-W., … Ko, J. L. (2010). N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 688(1), 72–77.
- Hsu, W. H., Chang, C. C., Huang, K. W., Chen, Y. C., Hsu, S. L., Wu, L. C., … Huang, C. Y. (2015). Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer. PLoS One, 10(4), e0121298.
- Hu, B., Sun, D., Sun, C., Sun, Y. F., Sun, H. X., Zhu, Q. F., … Xu, Y. (2015). A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma. Biochemical and Biophysical Research Communications, 468(4), 525–532.
- Huang, Y., Song, N., Ding, Y., Yuan, S., Li, X., Cai, H., … Luo, Y. (2009). Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Research, 69(19), 7529–7537.
- Huang, Y. F., Zhu, D. J., Chen, X. W., Chen, Q. K., Luo, Z. T., Liu, C. C., … Liao, N. Z. (2017). Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway. Oncotarget.
- Hugo, H., Ackland, M. L., Blick, T., Lawrence, M. G., Clements, J. A., Williams, E. D., & Thompson, E. W. (2007). Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression. Journal of Cellular Physiology, 213(2), 374–383.
- Iriti, M., & Faoro, F. (2004). Plant defense and human nutrition: Phenylpropanoids on the menu. Current Topics in Nutraceuticals Research, 2(1), 47–65.
- Iriti, M., & Faoro, F. (2009). Chemical diversity and defence metabolism: How plants cope with pathogens and ozone pollution. International Journal of Molecular Sciences, 10(8), 3371–3399.
- Iriti, M., & Varoni, E. M. (2013). Chemopreventive potential of flavonoids in oral squamous cell carcinoma in human studies. Nutrients, 5(7), 2564–2576.
- Iriti, M., & Varoni, E. M. (2014). Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol. Journal of Applied Biomedicine, 12(4), 193–202.
- Iriti, M, Varoni, EM. 2015. Brief introduction to polyphenols, bioactive phytochemicals for human health. Recent advances in medicinal chemistry 2: 3.
10.2174/9781681081717115020003 Google Scholar
- Isah, T. (2016). Anticancer alkaloids from trees: Development into drugs. Pharmacognosy Reviews, 10(20), 90–99.
- Islam, M. T. (2017). Diterpenes and their derivatives as potential anticancer agents. Phytotherapy Research.
- Ismail, A. M., In, L. L., Tasyriq, M., Syamsir, D. R., Awang, K., Mustafa, A. H., … Hasima, N. (2013). Extra virgin olive oil potentiates the effects of aromatase inhibitors via glutathione depletion in estrogen receptor-positive human breast cancer (MCF-7) cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 62, 817–824.
- Ito, S., Nakanishi, H., Ikehara, Y., Kato, T., Kasai, Y., Ito, K., … Tatematsu, M. (2001). Real-time observation of micrometastasis formation in the living mouse liver using a green fluorescent protein gene–tagged rat tongue carcinoma cell line. International Journal of Cancer, 93(2), 212–217.
- Janssen, G., Bode, U., Breu, H., Dohrn, B., Engelbrecht, V., & Gobel, U. (2000). Boswellic acids in the palliative therapy of children with progressive or relapsed brain tumors. Klinische Padiatrie, 212(4), 189–195.
- Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., … North Central Cancer Treatment Group. (2007). A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: Results of a phase II study from the North Central Cancer Treatment Group. Urology, 69(2), 289–294.
- Jatoi, A., Ellison, N., Burch, P. A., Sloan, J. A., Dakhil, S. R., Novotny, P., … Flynn, P. J. (2003). A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer, 97(6), 1442–1446.
- Jia, Z., Gao, Y., Wang, L., Li, Q., Zhang, J., Le, X., … Xie, K. (2010). Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Research, 70(3), 1111–1119.
- Jiang, Y. L., & Liu, Z. P. (2011). Natural products as anti-invasive and anti-metastatic agents. Current Medicinal Chemistry, 18(6), 808–829.
- Jutooru, I., Chadalapaka, G., Lei, P., & Safe, S. (2010). Inhibition of NFκB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Journal of Biological Chemistry, 285(33), 25332–25344.
- Jutooru, I., Guthrie, A. S., Chadalapaka, G., Pathi, S., Kim, K., Burghardt, R., … Safe, S. (2014). Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology, 34(13), 2382–2395.
- Kalalinia, F., & Karimi-Sani, I. (2017). Anticancer properties of solamargine: A systematic review. Phytotherapy Research.
- Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Kakonen, S. M., Cordón-Cardo, C., … Massagué, J. (2003). A multigenic program mediating breast cancer metastasis to bone. Cancer Cell, 3(6), 537–549.
- Karki, K., Hedrick, E., Kasiappan, R., Jin, U.-H., & Safe, S. (2017). Piperlongumine induces reactive oxygen species (ROS)-dependent downregulation of specificity protein transcription factors. Cancer Prevention Research, 10(8), 467–477.
- Kasiappan, R., Jutooru, I., Karki, K., Hedrick, E., & Safe, S. (2016). Benzyl isothiocyanate (BITC) induces reactive oxygen species-dependent repression of STAT3 protein by down-regulation of specificity proteins in pancreatic cancer. Journal of Biological Chemistry, 291(53), 27122–27133.
- Kazi, N., Radvany, R., Oldham, T., Keshavarzian, A., Frommel, TO, Libertin, C., & Mobarhan, S. (1997). Immunomodulatory effect of β-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer. Nutrition and Cancer, 28(2), 140–145.
- Khalife, R., Hodroj, M. H., Fakhoury, R., & Rizk, S. (2016). Thymoquinone from nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro. Planta Medica, 82(4), 312–321.
- Kim, C., Baek, S. H., Um, J. Y., Shim, B. S., & Ahn, K. S. (2016). Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPepsilon and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. BMC Nephrology, 17, 19.
- Kim, C. J., Isono, T., Tambe, Y., Chano, T., Okabe, H., Okada, Y., & Inoue, H. (2008). Role of alternative splicing of periostin in human bladder carcinogenesis. International Journal of Oncology, 32(1), 161–169.
- Kim, C. W., Hwang, K. A., & Choi, K. C. (2016). Anti-metastatic potential of resveratrol and its metabolites by the inhibition of epithelial-mesenchymal transition, migration, and invasion of malignant cancer cells. Phytomedicine, 23(14), 1787–1796.
- Kim, J. H., Gupta, S. C., Park, B., Yadav, V. R., & Aggarwal, B. B. (2012). Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-kappaB and NF-kappaB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Molecular Nutrition & Food Research, 56(3), 454–465.
- Kim, S. M., Lee, J. H., Sethi, G., Kim, C., Baek, S. H., Nam, D., … Ahn, K. S. (2014). Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells. Cancer Letters, 354(1), 153–163.
- Kim, Y. S., & Milner, J. A. (2005). Targets for indole-3-carbinol in cancer prevention. The Journal of Nutritional Biochemistry, 16(2), 65–73.
- Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., … Taketo, M. M. (2007). SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nature Genetics, 39(4), 467–475.
- Knobloch, T. J., Uhrig, L. K., Pearl, D. K., Casto, B. C., Warner, B. M., Clinton, S. K., … Weghorst, C. M. (2016). Suppression of proinflammatory and prosurvival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche. Cancer Prevention Research, 9(2), 159–171.
- Ko, J. C., Tsai, M. S., Kuo, Y. H., Chiu, Y. F., Weng, S. H., Su, Y. C., & Lin, Y. W. (2011). Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine. Biochemical Pharmacology, 81(5), 680–690.
- Konstantopoulos, K., & Thomas, S. N. (2009). Cancer cells in transit: The vascular interactions of tumor cells. Annual Review of Biomedical Engineering, 11, 177–202.
- Kotecha, R., Takami, A., & Espinoza, J. L. (2016). Dietary phytochemicals and cancer chemoprevention: A review of the clinical evidence. Oncotarget, 7(32), 52517–52529.
- Krakhmal, N, Zavyalova, M, Denisov, E, Vtorushin, S, Perelmuter, V. 2015. Cancer invasion: Patterns and mechanisms. Acta Naturae (англоязычная версия) 7(2 (25)).
- Kucuk, O., Sarkar, F. H., Sakr, W., Djuric, Z., Pollak, M. N., Khachik, F., … Wood, D. P. Jr. (2001). Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiology Biomarkers and Prevention, 10(8), 861–868.
- Kummar, S., Copur, M. S., Rose, M., Wadler, S., Stephenson, J., O'Rourke, M., … Chu, E. (2011). A phase I study of the chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer. Clinical Colorectal Cancer, 10(2), 85–96.
- Kunita, A., Kashima, T. G., Morishita, Y., Fukayama, M., Kato, Y., Tsuruo, T., & Fujita, N. (2007). The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. The American Journal of Pathology, 170(4), 1337–1347.
- Kunnumakkara, A. B., Bordoloi, D., Padmavathi, G., Monisha, J., Roy, N. K., Prasad, S., & Aggarwal, B. B. (2017). Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases. British Journal of Pharmacology, 174(11), 1325–1348.
- Kunnumakkara, A. B., Diagaradjane, P., Anand, P., Harikumar, K. B., Deorukhkar, A., Gelovani, J., … Aggarwal, B. B. (2009). Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. International Journal of Cancer, 125(9), 2187–2197.
- Labelle, M., Begum, S., & Hynes, R. O. (2011). Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell, 20(5), 576–590.
- Lam, W., Jiang, Z., Guan, F., Huang, X., Hu, R., Wang, J., … Cheng, Y. C. (2015). PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment. Scientific Reports, 5, 9384.
- Lee, S., Han, S., Jeong, A. L., Park, J. S., Jung, S. H., Choi, K. D., & Yang, Y. (2015). Combined treatment of herbal mixture extract H9 with trastuzumab enhances anti-tumor growth effect. Journal of Microbiology and Biotechnology, 25(7), 1036–1046.
- Leeman-Neill, R. J., Wheeler, S. E., Singh, S. V., Thomas, S. M., Seethala, R. R., Neill, D. B., … Grandis, J. R. (2009). Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis, 30(11), 1848–1856.
- Lelli, D., Pedone, C., & Sahebkar, A. (2017). Curcumin and treatment of melanoma: The potential role of microRNAs. Biomedicine and Pharmacotherapy, 88, 832–834.
- Li, F., Chow, S., Cheung, W. H., Chan, F. L., Chen, S., & Leung, L. K. (2013). The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer. The Journal of Nutritional Biochemistry, 24(6), 1112–1116.
- Li, F., Rajendran, P., & Sethi, G. (2010). Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. British Journal of Pharmacology, 161(3), 541–554.
- Li, M., Zhang, L., Ge, C., Chen, L., Fang, T., Li, H., … Li, J. (2015). An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma. Oncotarget, 6(28), 25149–25160.
- Li, S., Liu, Z., Zhu, F., Fan, X., Wu, X., Zhao, H., & Jiang, L. (2013). Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Oncology Research, 21(3), 137–144.
- Li, S., Wu, L., Feng, J., Li, J., Liu, T., Zhang, R., … Guo, C. (2016). In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity. Scientific Reports, 6, 28479.
- Liang, C. H., Shiu, L. Y., Chang, L. C., Sheu, H. M., Tsai, E. M., & Kuo, K. W. (2008). Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chemical Research in Toxicology, 21(2), 393–399.
- Liang, Y., Zheng, T., Song, R., Wang, J., Yin, D., Wang, L., … Liu, L. (2013). Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1alpha inhibition in hepatocellular carcinoma. Hepatology, 57(5), 1847–1857.
- Liang, Y. J., Hao, Q., Wu, Y. Z., Wang, Q. L., Wang, J. D., & Hu, Y. L. (2009). Aromatase inhibitor letrozole in synergy with curcumin in the inhibition of xenografted endometrial carcinoma growth. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19(7), 1248–1252.
- Lin, B. W., Gong, C. C., Song, H. F., & Cui, Y. Y. (2017). Effects of anthocyanins on the prevention and treatment of cancer. British Journal of Pharmacology, 174(11), 1226–1243.
- Liu, G., Oettel, K., Bailey, H., Van Ummersen, L., Tutsch, K., Staab, M. J., … Wilding, G. (2003). Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. Investigational New Drugs, 21(3), 367–372.
- Loboda, A., Jozkowicz, A., & Dulak, J. (2012). HIF-1 versus HIF-2—is one more important than the other? Vascular Pharmacology, 56(5), 245–251.
- Lodish, H. (2008). Molecular cell biology. Macmillan.
- Lodish, H., Baltimore, D., Berk, A., Zipursky, S. L., Matsudaira, P., & Darnell, J. (1995). Molecular cell biology. Scientific American Books New York.
- Lopes, G., & Rocha Lima, C. M. (2005). Docetaxel in the management of advanced pancreatic cancer. Seminars in Oncology, 32(2 Suppl 4), S10–S23.
- Lu, D.-Y., Lu, T.-R., Wu, H.-Y., & Cao, S. (2013). Cancer metastasis treatments. Current Drug Therapy, 8(1), 24–29.
- Lü, S., & Wang, J. (2014). Homoharringtonine and omacetaxine for myeloid hematological malignancies. Journal of Hematology & Oncology, 7, 2–2.
- Luo, K. W., Yue, G. G., Ko, C. H., Gao, S., Lee, J. K., Li, G., … Lau, C. B. (2015). The combined use of Camellia sinensis and metronomic zoledronate in 4T1 mouse carcinoma against tumor growth and metastasis. Oncology Reports, 34(1), 477–487.
- Manetta, A., Schubbert, T., Chapman, J., Schell, M. J., Peng, Y. M., Liao, S. Y., & Meyskens, F. J. Jr. (1996). β-carotene treatment of cervical intraepithelial neoplasia: A phase II study. Cancer Epidemiology Biomarkers and Prevention, 5(11), 929–932.
- Margalit, D. N., Kasperzyk, J. L., Martin, N. E., Sesso, H. D., Gaziano, J. M., Ma, J., … Mucci, L. A. (2012). Beta-carotene antioxidant use during radiation therapy and prostate cancer outcome in the physicians' health study. International Journal of Radiation Oncology Biology Physics, 83(1), 28–32.
- Mariani, S., Lionetto, L., Cavallari, M., Tubaro, A., Rasio, D., De Nunzio, C., … Simmaco, M. (2014). Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. International Journal of Molecular Sciences, 15(1), 1433–1440.
- Marin, D., Kaeda, J. S., Andreasson, C., Saunders, S. M., Bua, M., Olavarria, E., … Apperley, J. F. (2005). Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib. Cancer, 103(9), 1850–1855.
- Martí, R., Roselló, S., & Cebolla-Cornejo, J. (2016). Tomato as a source of carotenoids and polyphenols targeted to cancer prevention. Cancer, 8(6).
- Martin, T. A., & Jiang, W. G. (2009). Loss of tight junction barrier function and its role in cancer metastasis. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1788(4), 872–891.
- Martin, TA, Ye, L, Sanders, AJ, Lane, J, Jiang, WG. 2013. Cancer invasion and metastasis: Molecular and cellular perspective.
- Mason, J. K., Chen, J., & Thompson, L. U. (2010). Flaxseed oil-trastuzumab interaction in breast cancer. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(8–9), 2223–2226.
- Matos, J. M., Schmidt, C. M., Thomas, H. J., Cummings, O. W., Wiebke, E. A., Madura, J. A., … Crowell, P. L. (2008). A pilot study of perillyl alcohol in pancreatic cancer. Journal of Surgical Research, 147(2), 194–199.
- Mayne, S. T., Cartmel, B., Baum, M., Shor-Posner, G., Fallon, B. G., Briskin, K., … Goodwin, W. J. Jr. (2001). Randomized trial of supplemental β-carotene to prevent second head and neck cancer. Cancer Research, 61(4), 1457–1463.
- McLarty, J., Bigelow, R. L., Smith, M., Elmajian, D., Ankem, M., & Cardelli, J. A. (2009). Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro. Cancer Prevention Research (Philadelphia, Pa.), 2(7), 673–682.
- McNaught, A. D., & Wilkinson, A. (2006a). IUPAC. Compendium of chemical terminology. In M. Nic, & B. Kosata (Eds.), ( 2nd ed.). Oxford, UK: Blackwell Scientific Publications. http://goldbook.iupac.org/html/F/F02424.html
- McNaught, A. D., & Wilkinson, A. (2006b). IUPAC. Compendium of chemical terminology. In M. Nic, & B. Kosata (Eds.), ( 2nd ed.). Oxford, UK: Blackwell Scientific Publications. http://www.iupac.org/goldbook/A00220.pdf
- Menendez, J. A., Vazquez-Martin, A., Colomer, R., Brunet, J., Carrasco-Pancorbo, A., Garcia-Villalba, R., … Segura-Carretero, A. (2007). Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer, 7, 80.
- Menendez, J. A., Vellon, L., Colomer, R., & Lupu, R. (2005). Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Annals of oncology : official journal of the European Society for Medical Oncology, 16(3), 359–371.
- Messing, E., Gee, J. R., Saltzstein, D. R., Kim, K., DiSant'Agnese, A., Kolesar, J., … Bailey, H. (2012). A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients. Cancer Prevention Research, 5(4), 621–630.
- Meybodi, N. M., Mortazavian, A. M., Monfared, A. B., Sohrabvandi, S., & Meybodi, F. A. (2017). Phytochemicals in cancer prevention: A review of the evidence. Iranian Journal of Cancer Prevention, 10(1).
- Milligan, S. A., Burke, P., Coleman, D. T., Bigelow, R. L., Steffan, J. J., Carroll, J. L., … Cardelli, J. A. (2009). The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 15(15), 4885–4894.
- Mishra, A. P., Salehi, B., Sharifi-Rad, M., Pezzani, R., Kobarfard, F., Sharifi-Rad, J., & Nigam, M. (2018). Programmed cell death, from a cancer perspective: An overview. Molecular Diagnosis & Therapy, 1–15. https://doi.org/10.1007/s40291-018-0329-9
- Mirzaei, H., Naseri, G., Rezaee, R., Mohammadi, M., Banikazemi, Z., Mirzaei, H. R., … Sahebkar, A. (2016). Curcumin: A new candidate for melanoma therapy? International Journal of Cancer, 139(8), 1683–1695.
- Mitchell, M. J., & King, M. R. (2013). Fluid shear stress sensitizes cancer cells to receptor-mediated apoptosis via trimeric death receptors. New Journal of Physics, 15(1), 015008.
- Mondal, A., & Bennett, L. L. (2016). Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS, cell cycle inhibition, caspase 3 and PARP cleavage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 1906–1914.
- Morbidelli, L. (2016). Polyphenol-based nutraceuticals for the control of angiogenesis: Analysis of the critical issues for human use. Pharmacological Research, 111, 384–393.
- Mundy, G. R. (2002). Metastasis: Metastasis to bone: Causes, consequences and therapeutic opportunities. Nature Reviews Cancer, 2(8), 584–593.
- Nazha, A., Kantarjian, H., Cortes, J., & Quintas-Cardama, A. (2013). Omacetaxine mepesuccinate (synribo)—Newly launched in chronic myeloid leukemia. Expert Opinion on Pharmacotherapy, 14(14), 1977–1986.
- Neerati, P., Sudhakar, Y. A., & Kanwar, J. R. (2013). Curcumin regulates colon cancer by inhibiting P-glycoprotein in in-situ cancerous colon perfusion rat model. Journal of cancer science & therapy, 5, 313–319.
- Newman, D. J., & Cragg, G. M. (2016). Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products, 79(3), 629–661.
- Nguyen, A. V., Martinez, M., Stamos, M. J., Moyer, M. P., Planutis, K., Hope, C., … Holcombe, R. F. (2009). Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Management and Research, 1, 25–37.
- Nguyen, D. X., Bos, P. D., & Massagué, J. (2009). Metastasis: From dissemination to organ-specific colonization. Nature Reviews Cancer, 9(4), 274–284.
- Nie, P., Hu, W., Zhang, T., Yang, Y., Hou, B., & Zou, Z. (2015). Synergistic induction of erlotinib-mediated apoptosis by resveratrol in human non-small-cell lung cancer cells by down-regulating survivin and up-regulating PUMA. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(6), 2255–2271.
- Nieto, M. A. (2013). Epithelial plasticity: A common theme in embryonic and cancer cells. Science, 342(6159), 1234850.
- Nishida, N., Yano, H., Nishida, T., Kamura, T., & Kojiro, M. (2006). Angiogenesis in cancer. Vascular Health and Risk Management, 2(3), 213–219.
- O'Brien, S., Giles, F., Talpaz, M., Cortes, J., Rios, M. B., Shan, J., … Kantarjian, H. M. (2003). Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase. Cancer, 98(5), 888–893.
- O'Brien, S., Kantarjian, H., Koller, C., Feldman, E., Beran, M., Andreeff, M., … Talpaz, M. (1999). Sequential homoharringtonine and interferon-α in the treatment of early chronic phase chronic myelogenous leukemia. Blood, 93(12), 4149–4153.
- Pal, H. C., Baxter, R. D., Hunt, K. M., Agarwal, J., Elmets, C. A., Athar, M., … Afaq, F. (2015). Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget, 6(29), 28296–28311.
- Palumbo, J. S., Talmage, K. E., Massari, J. V., La Jeunesse, C. M., Flick, M. J., Kombrinck, K. W., … Degen, J. L. (2005). Platelets and fibrin (ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells. Blood, 105(1), 178–185.
- Panic, N., Nedovic, D., Pastorino, R., Boccia, S., & Leoncini, E. (2017). Carotenoid intake from natural sources and colorectal cancer: A systematic review and meta-analysis of epidemiological studies. European Journal of Cancer Prevention, 26(1), 27–37.
- Papineni, S., Chintharlapalli, S., Abdelrahim, M., Lee, S.-O., Burghardt, R., Abudayyeh, A., … Safe, S. (2009). Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis, 30(7), 1193–1201.
- Park, M. H., Hong, J. E., Hwang, C. J., Choi, M., Choi, J. S., An, Y. J., … Hong, J. T. (2016). Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal. Archives of Pharmacal Research, 39(5), 721–729.
- Parsons, H. A., Baracos, V. E., Hong, D. S., Abbruzzese, J., Bruera, E., & Kurzrock, R. (2016). The effects of curcumin (diferuloylmethane) on body composition of patients with advanced pancreatic cancer. Oncotarget, 7(15), 20293–20304.
- Patel, K. R., Brown, V. A., Jones, D. J., Britton, R. G., Hemingway, D., Miller, A. S., … Brown, K. (2010). Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Research, 70(19), 7392–7399.
- Pathi, S., Jutooru, I., Chadalapaka, G., Nair, V., Lee, S.-O., & Safe, S. (2012). Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS One, 7(10), e48208.
- Phromnoi, K., Prasad, S., Gupta, S. C., Kannappan, R., Reuter, S., Limtrakul, P., & Aggarwal, B. B. (2011). Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. Molecular Pharmacology, 80(5), 889–899.
- Prasad, R., & Katiyar, S. K. (2012). Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules. PLoS One, 7(9), e46404.
- Prasad, S., Yadav, V. R., Sung, B., Reuter, S., Kannappan, R., Deorukhkar, A., … Aggarwal, B. B. (2012). Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: Chemosensitization with capecitabine. Clinical cancer research : an official journal of the American Association for Cancer Research, 18(18), 4942–4953.
- Qazi, H., Shi, Z.-D., & Tarbell, J. M. (2011). Fluid shear stress regulates the invasive potential of glioma cells via modulation of migratory activity and matrix metalloproteinase expression. PLoS One, 6(5), e20348.
- Quintas-Cardama, A., Kantarjian, H., Garcia-Manero, G., O'Brien, S., Faderl, S., Estrov, Z., … Cortes, J. (2007). Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy. Cancer, 109(2), 248–255.
- Redondo-Blanco, S., Fernández, J., Gutiérrez-del-Río, I., Villar, C. J., & Lombó, F. (2017). New insights toward colorectal cancer chemotherapy using natural bioactive compounds. Frontiers in Pharmacology, 8(MAR).
- Reymond, N., d'Agua, B. B., & Ridley, A. J. (2013). Crossing the endothelial barrier during metastasis. Nature Reviews Cancer, 13(12), 858–870.
- Ripple, G. H., Gould, M. N., Stewart, J. A., Tutsch, K. D., Arzoomanian, R. Z., Alberti, D., … Bailey, H. H. (1998). Phase I clinical trial of perillyl alcohol administered daily. Clinical Cancer Research, 4(5), 1159–1164.
- Safe, S., & Kasiappan, R. (2016). Natural products as mechanism-based anticancer agents: Sp transcription factors as targets. Phytotherapy Research, 30(11), 1723–1732.
- Saibabu, V., Fatima, Z., Khan, L. A., & Hameed, S. (2015). Therapeutic potential of dietary phenolic acids. Advances in Pharmacological Sciences, 2015.
- Saif, M. W., Lansigan, F., Ruta, S., Lamb, L., Mezes, M., Elligers, K., … Cheng, Y. C. (2010). Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies. Phytomedicine, 17(3–4), 161–169.
- Saif, M. W., Li, J., Lamb, L., Kaley, K., Elligers, K., Jiang, Z., … Cheng, Y. C. (2014). First-in-human phase II trial of the botanical formulation PHY906 with capecitabine as second-line therapy in patients with advanced pancreatic cancer. Cancer Chemotherapy and Pharmacology, 73(2), 373–380.
- Salehi, B., Ayatollahi, S. A., Segura-Carretero, A., Kobarfard, F., Contreras, M. d. M., Faizi, M., … Sharifi-Rad, J. (2017). Bioactive chemical compounds in Eremurus persicus (Joub. & Spach) Boiss. essential oil and their health implications. Cellular and Molecular Biology (Noisy le Grand), 63(9), 1–7.
- Sandur, S. K., Pandey, M. K., Sung, B., & Aggarwal, B. B. (2010). 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: Potential role in chemosensitization. Molecular Cancer Research : MCR, 8(1), 107–118.
- Sanjust, E., Mocci, G., Zucca, P., & Rescigno, A. (2008). Mediterranean shrubs as potential antioxidant sources. Natural Product Research, 22(8), 689–708.
- Schöffski, P., Breidenbach, I., Krauter, J., Bolte, O., Stadler, M., Ganser, A., … Lentzen, H. (2005). Weekly 24 h infusion of aviscumine (rViscumin): A phase I study in patients with solid tumours. European Journal of Cancer, 41(10), 1431–1438.
- Schöffski, P., Riggert, S., Fumoleau, P., Campone, M., Bolte, O., Marreaud, S., … European Organization for Research and Treatment of Cancer New Drug Development Group. (2004). Phase I trial of intravenous aviscumine (rViscumin) in patients with solid tumors: A study of the European organization for research and treatment of cancer new drug development group. Annals of Oncology, 15(12), 1816–1824.
- Schwenke, C., Ubrig, B., Thürmann, P., Eggersmann, C., & Roth, S. (2009). Lycopene for advanced hormone refractory prostate cancer: A prospective, open phase II pilot study. Journal of Urology, 181(3), 1098–1103.
- Shanmugam, M. K., Lee, J. H., Chai, E. Z. P., Kanchi, M. M., Kar, S., Arfuso, F., … Sethi, G. (2016). Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds. Seminars in Cancer Biology, 40_41, 35–47.
- Shapira, S., Pleban, S., Kazanov, D., Tirosh, P., & Arber, N. (2016). Terpinen-4-ol: A novel and promising therapeutic agent for human gastrointestinal cancers. PLoS One, 11(6), e0156540.
- Sharifi-Rad, J., Ayatollahi, S. A., Varoni, E. M., Salehi, B., Kobarfard, F., Sharifi-Rad, M., … Sharifi-Rad, M. (2017). Chemical composition and functional properties of essential oils from Nepeta schiraziana Boiss. Farmacia, 65(5), 802–812.
- Sharifi-Rad, J., Hoseini-Alfatemi, S. M., Sharifi-Rad, M., Sharifi-Rad, M., Iriti, M., Sharifi-Rad, M., … Raeisi, S. (2015). Phytochemical compositions and biological activities of essential oil from Xanthium strumarium L. Molecules, 20(4), 7034–7047.
- Sharifi-Rad, J., Salehi, B., Stojanović-Radić, Z. Z., Fokou, P. V. T., Sharifi-Rad, M., Mahady, G. B., … Iriti, M. (2017). Medicinal plants used in the treatment of tuberculosis-Ethnobotanical and ethnopharmacological approaches. Biotechnology Advances, https://doi.org10.1016/j.biotechadv.2017.07.001
- Sharifi-Rad, J., Salehi, B., Varoni, E. M., Sharopov, F., Yousaf, Z., Ayatollahi, S. A., … Iriti, M. (2017). Plants of the Melaleuca genus as antimicrobial agents: From farm to pharmacy. Phytotherapy Research, 31(10), 1475–1494.
- Sharifi-Rad, J., Sharifi-Rad, M., Hoseini-Alfatemi, S. M., Iriti, M., Sharifi-Rad, M., & Sharifi-Rad, M. (2015). Composition, cytotoxic and antimicrobial activities of Satureja intermedia CA Mey essential oil. International Journal of Molecular Sciences, 16(8), 17812–17825.
- Sharifi-Rad, J., Sureda, A., Tenore, G. C., Daglia, M., Sharifi-Rad, M., Valussi, M., … Iriti, M. (2017). Biological activities of essential oils: From plant chemoecology to traditional healing systems. Molecules, 22(1), 70.
- Sharifi-Rad, M., Varoni, E. M., Salehi, B., Sharifi-Rad, J., Matthews, K. R., Ayatollahi, S. A., … Rigano, D. (2017). Plants of the Genus Zingiber as a source of bioactive phytochemicals: From tradition to pharmacy. Molecules, 22(12), 2145.
- Shenoy, A. K., & Lu, J. (2016). Cancer cells remodel themselves and vasculature to overcome the endothelial barrier. Cancer Letters, 380(2), 534–544.
- Shibue, T., & Weinberg, R. A. (2011). Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Seminars in Cancer Biology, 21(2), 99–106.
- Short, B. (2009). Fibroblasts invade at a Snail's pace. Rockefeller. University Press.
- Sinha, D., Sarkar, N., Biswas, J., & Bishayee, A. (2016). Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Seminars in Cancer Biology, 40_41, 209–232.
- Smeriglio, A., Barreca, D., Bellocco, E., & Trombetta, D. (2017). Proanthocyanidins and hydrolysable tannins: Occurrence, dietary intake and pharmacological effects. British Journal of Pharmacology, 174(11), 1244–1262.
- Stivarou, T., & Patsavoudi, E. (2015). Extracellular molecules involved in cancer cell invasion. Cancer, 7(1), 238–265.
- Stoletov, K., Kato, H., Zardouzian, E., Kelber, J., Yang, J., Shattil, S., & Klemke, R. (2010). Visualizing extravasation dynamics of metastatic tumor cells. Journal of Cell Science, 123(13), 2332–2341.
- Strell, C., & Entschladen, F. (2008). Extravasation of leukocytes in comparison to tumor cells. Cell Communication and Signaling, 6(1), 10.
- Subramani, P. A., Panati, K., & Narala, V. R. (2017). Curcumin nanotechnologies and its anticancer activity. Nutrition and Cancer, 69(3), 381–393.
- Sundar, S. N., Marconett, C. N., Doan, V. B., Willoughby, J. A. Sr., & Firestone, G. L. (2008). Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells. Carcinogenesis, 29(12), 2252–2258.
- Sung, B., Kunnumakkara, A. B., Sethi, G., Anand, P., Guha, S., & Aggarwal, B. B. (2009). Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Molecular Cancer Therapeutics, 8(4), 959–970.
- Takagi, S., Sato, S., Oh-hara, T., Takami, M., Koike, S., Mishima, Y., … Fujita, N. (2013). Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2. PLoS One, 8(8), e73609.
- Tan, D. S., Agarwal, R., & Kaye, S. B. (2006). Mechanisms of transcoelomic metastasis in ovarian cancer. The Lancet Oncology, 7(11), 925–934.
- Tariq, A., Sadia, S., Pan, K., Ullah, I., Mussarat, S., Sun, F., … Adnan, M. (2017). A systematic review on ethnomedicines of anti-cancer plants. Phytotherapy Research.
- Thiery, J. P., Acloque, H., Huang, R. Y., & Nieto, M. A. (2009). Epithelial-mesenchymal transitions in development and disease. Cell, 139(5), 871–890.
- Toma, S., Bonelli, L., Sartoris, A., Mira, E., Antonelli, A., Beatrice, F., … Cortesina, G. (2003). beta-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial. Oncology Reports, 10(6), 1895–1901.
- Trefzer, U., Gutzmer, R., Wilhelm, T., Schenck, F., Kahler, K. C., Jacobi, V., … Mohr, P. (2014). Treatment of unresectable stage IV metastatic melanoma with aviscumine after anti-neoplastic treatment failure: A phase II, multi-centre study. Journal for immunotherapy of cancer, 2, 27.
- Tyagi, A. K., Prasad, S., Yuan, W., Li, S., & Aggarwal, B. B. (2015). Identification of a novel compound (beta-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: Comparison with curcumin. Investigational New Drugs, 33(6), 1175–1186.
- Tysnes, B. B., & Bjerkvig, R. (2007). Cancer initiation and progression: Involvement of stem cells and the microenvironment. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1775(2), 283–297.
- Uppal, A., Wightman, S. C., Ganai, S., Weichselbaum, R. R., & An, G. (2014). Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model. Theoretical Biology and Medical Modelling, 11(1), 17.
- Van Zijl, F., Krupitza, G., & Mikulits, W. (2011). Initial steps of metastasis: Cell invasion and endothelial transmigration. Mutation Research/Reviews in Mutation Research, 728(1), 23–34.
- Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszar, A., … Wu, J. M. (2011). What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One, 6(6).
- Varoni, E. M., Faro, A. F. L., Sharifi-Rad, J., & Iriti, M. (2016). Anticancer molecular mechanisms of resveratrol. Frontiers in nutrition, 3.
- Varoni, E. M., Lodi, G., Sardella, A., Carrassi, A., & Iriti, M. (2012). Plant polyphenols and oral health: Old phytochemicals for new fields. Current Medicinal Chemistry, 19(11), 1706–1720.
- Vincent, T. L., & Gatenby, R. A. (2008). An evolutionary model for initiation, promotion, and progression in carcinogenesis. International Journal of Oncology, 32(4), 729–738.
- Von Minckwitz, G. (2007). Docetaxel/anthracycline combinations for breast cancer treatment. Expert Opinion on Pharmacotherapy, 8(4), 485–495.
- Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004). High absorption but very low bioavailability of oral resveratrol in humans. Drug Metabolism and Disposition, 32(12), 1377–1382.
- Wang, C. Z., Xie, J. T., Zhang, B., Ni, M., Fishbein, A., Aung, H. H., … Yuan, C. S. (2007). Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. International Journal of Oncology, 31(5), 1149–1156.
- Wang, S., Willenberg, I., Krohn, M., Hecker, T., Meckelmann, S., Li, C., … Empl, M. T. (2017). Growth-inhibiting activity of resveratrol imine analogs on tumor cells in vitro. PLoS One, 12(1), e0170502.
- Wang, Y., Liu, J., Ying, X., Lin, P. C., & Zhou, B. P. (2016). Twist-mediated epithelial-mesenchymal transition promotes breast tumor cell invasion via inhibition of hippo pathway. Scientific Reports, 6.
- Weber, G. F. (2013). Why does cancer therapy lack effective anti-metastasis drugs? Cancer Letters, 328(2), 207–211.
- Weiskirchen, S., & Weiskirchen, R. (2016). Resveratrol: How much wine do you have to drink to stay healthy? Advances in nutrition (Bethesda, Md.), 7(4), 706–718.
- Weissenstein, U., Kunz, M., Urech, K., Regueiro, U., & Baumgartner, S. (2016). Interaction of a standardized mistletoe (Viscum album) preparation with antitumor effects of Trastuzumab in vitro. BMC Complementary and Alternative Medicine, 16, 271.
- Wu, C. C., Huang, Y. F., Hsieh, C. P., Chueh, P. J., & Chen, Y. L. (2016). Combined use of zoledronic acid augments ursolic acid-induced apoptosis in human osteosarcoma cells through enhanced oxidative stress and autophagy. Molecules, 21(12).
- Wu, J., Wu, S., Shi, L., Zhang, S., Ren, J., Yao, S., … Liang, G. (2017). Design, synthesis, and evaluation of asymmetric EF24 analogues as potential anti-cancer agents for lung cancer. European Journal of Medicinal Chemistry, 125, 1321–1331.
- Xu, J. H., Yang, H. P., Zhou, X. D., Wang, H. J., Gong, L., & Tang, C. L. (2015). Role of wnt inhibitory factor-1 in inhibition of bisdemethoxycurcumin mediated epithelial-to-mesenchymal transition in highly metastatic lung cancer 95D cells. Chinese Medical Journal, 128(10), 1376–1383.
- Yamauchi, Y., Izumi, Y., Yamamoto, J., & Nomori, H. (2014). Coadministration of erlotinib and curcumin augmentatively reduces cell viability in lung cancer cells. Phytotherapy research : PTR, 28(5), 728–735.
- Yen, Y., So, S., Rose, M., Saif, M. W., Chu, E., Liu, S. H., … Cheng, Y. C. (2009). Phase I/II study of PHY906/capecitabine in advanced hepatocellular carcinoma. Anticancer Research, 29(10), 4083–4092.
- Yilmaz, M., & Christofori, G. (2010). Mechanisms of motility in metastasizing cells. Molecular Cancer Research, 8(5), 629–642.
- Yin, J. J., Selander, K., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., … Guise, T. A. (1999). TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. The Journal of Clinical Investigation, 103(2), 197–206.
- Yin, M., Li, X., Tan, S., Zhou, H. J., Ji, W., Bellone, S., … Min, W. (2016). Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. The Journal of Clinical Investigation, 126(11), 4157–4173.
- Yin, T. F., Wang, M., Qing, Y., Lin, Y. M., & Wu, D. (2016). Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms. World Journal of Gastroenterology, 22(31), 7058–7068.
- Yu, J., Peng, Y., Wu, L.-C., Xie, Z., Deng, Y., Hughes, T., … Liu, Z. (2013). Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS One, 8(2), e55934.
- Yue, G. G., Kwok, H. F., Lee, J. K., Jiang, L., Wong, E. C., Gao, S., … Lau, C. B. (2016). Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice. Pharmacological Research, 111, 43–57.
- Zaheer, K., & Humayoun Akhtar, M. (2017). An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health. Critical Reviews in Food Science and Nutrition, 57(6), 1280–1293.
- Zetter, P., & Bruce, R. (1998). Angiogenesis and tumor metastasis. Annual Review of Medicine, 49(1), 407–424.
- Zhang, C. Z., Fang, E. F., Zhang, H. T., Liu, L. L., & Yun, J. P. (2015). Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. Investigational New Drugs, 33(1), 1–11.
- Zhang, J., Yu, J., Xie, R., Chen, W., & Lv, Y. (2016). Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways. Natural Product Research, 30(16), 1858–1861.
- Zhang, L., Huang, Y., Zhuo, W., Zhu, Y., Zhu, B., & Chen, Z. (2016). Fisetin, a dietary phytochemical, overcomes Erlotinib-resistance of lung adenocarcinoma cells through inhibition of MAPK and AKT pathways. American Journal of Translational Research, 8(11), 4857–4868.
- Zhang, P., Bai, H., Liu, G., Wang, H., Chen, F., Zhang, B., … Song, E. (2015). MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2. Toxicology Letters, 234(3), 151–161.
- Zhang, X., Yang, Y., & Wang, Q. (2014). Lycopene can reduce prostate-specific antigen velocity in a phase ii clinical study in Chinese population. Chinese Medical Journal, 127(11), 2143–2146.
- Zhang, X., Zhang, H., Tighiouart, M., Lee, J. E., Shin, H. J., Khuri, F. R., … Shin, D. M. (2008). Synergistic inhibition of head and neck tumor growth by green tea (−)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor. International Journal of Cancer, 123(5), 1005–1014.
- Zhou, Y., Tang, J., Du, Y., Ding, J., & Liu, J. Y. (2016). The green tea polyphenol EGCG potentiates the antiproliferative activity of sunitinib in human cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37(7), 8555–8566.
- Zhu, D. J., Chen, X. W., Wang, J. Z., Ju, Y. L., Ou Yang, M. Z., & Zhang, W. J. (2014). Proteomic analysis identifies proteins associated with curcumin-enhancing efficacy of irinotecan-induced apoptosis of colorectal cancer LOVO cell. International Journal of Clinical and Experimental Pathology, 7(1), 1–15.
- Zhu, D. J., Huang, Y. F., Chen, X. W., Luo, Z. T., Wang, G. X., Liu, C. C., … Ouyang, M. Z. (2016). Curcumin partly ameliorates irinotecan-induced diarrhea and synergistically promotes apoptosis in colorectal cancer through mediating oxidative stress. Oncotarget.
- Zhu, W., Qin, W., Zhang, K., Rottinghaus, G. E., Chen, Y. C., Kliethermes, B., & Sauter, E. R. (2012). Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutrition and Cancer, 64(3), 393–400.
- Ziegler, R. G. (1989). A review of epidemiologic evidence that carotenoids reduce the risk of cancer. Journal of Nutrition, 119(1), 116–122.
- Zucca, P., Argiolas, A., Nieddu, M., Pintus, M., Rosa, A., Sanna, F., … Rescigno, A. (2016). Biological activities and nutraceutical potentials of water extracts from different parts of cynomorium Coccineum L. (Maltese Mushroom). Polish Journal of Food and Nutrition Sciences, 66(3), 179–188.
- Zucca, P., Rosa, A., Tuberoso, C. I., Piras, A., Rinaldi, A. C., Sanjust, E., … Rescigno, A. (2013). Evaluation of antioxidant potential of “Maltese Mushroom”(Cynomorium coccineum) by means of multiple chemical and biological assays. Nutrients, 5(1), 149–161.
- Zucca, P., Sanjust, E., Trogu, E., Sollai, F., & Rescigno, A. (2010). Evaluation of antioxidant capacity of antioxidant-declared beverages marketed in Italy. Italian Journal of Food Science, 22(3), 313–319.
- Zwierzina, H., Bergmann, L., Fiebig, H., Aamdal, S., Schoffski, P., Witthohn, K., … Lentzen, H. (2011). The preclinical and clinical activity of aviscumine: a potential anticancer drug. European journal of cancer (Oxford, England : 1990), 47(10), 1450–1457.
Citing Literature
