Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection?
Jitka Vostalova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorCorresponding Author
Ales Vidlar
Department of Urology, University Hospital, I.P. Pavlova 5, 77500 Olomouc, Czech Republic
Correspondence to: Ales Vidlar, Department of Urology, University Hospital, I.P. Pavlova 5, 77500 Olomouc, Czech Republic.
E-mail: [email protected]
Search for more papers by this authorVilim Simanek
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorAdela Galandakova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorPavel Kosina
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorJan Vacek
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorJana Vrbkova
Institute of Molecular and Translational Medicine Department, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorBenno F. Zimmermann
Department of Nutritional and Food Sciences - Chair of Food and Technology and Food Biotechnology, University of Bonn, Römmerstrasse 164, 53117 Bonn, Germany
Institut Prof. Dr. Georg Kurz GmbH, Stöckheimer Weg 1, 50829 Köln, Germany
Search for more papers by this authorJitka Ulrichova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorVladimir Student
Department of Urology, University Hospital, I.P. Pavlova 5, 77500 Olomouc, Czech Republic
Search for more papers by this authorJitka Vostalova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorCorresponding Author
Ales Vidlar
Department of Urology, University Hospital, I.P. Pavlova 5, 77500 Olomouc, Czech Republic
Correspondence to: Ales Vidlar, Department of Urology, University Hospital, I.P. Pavlova 5, 77500 Olomouc, Czech Republic.
E-mail: [email protected]
Search for more papers by this authorVilim Simanek
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorAdela Galandakova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorPavel Kosina
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorJan Vacek
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorJana Vrbkova
Institute of Molecular and Translational Medicine Department, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorBenno F. Zimmermann
Department of Nutritional and Food Sciences - Chair of Food and Technology and Food Biotechnology, University of Bonn, Römmerstrasse 164, 53117 Bonn, Germany
Institut Prof. Dr. Georg Kurz GmbH, Stöckheimer Weg 1, 50829 Köln, Germany
Search for more papers by this authorJitka Ulrichova
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic
Search for more papers by this authorVladimir Student
Department of Urology, University Hospital, I.P. Pavlova 5, 77500 Olomouc, Czech Republic
Search for more papers by this authorAbstract
Most research on American cranberry in the prevention of urinary tract infection (UTI) has used juices. The spectrum of components in juice is limited. This study tested whether whole cranberry fruit powder (proanthocyanidin content 0.56%) could prevent recurrent UTI in 182 women with two or more UTI episodes in the last year. Participants were randomized to a cranberry (n = 89) or a placebo group (n = 93) and received daily 500 mg of cranberry for 6 months. The number of UTI diagnoses was counted. The intent-to-treat analyses showed that in the cranberry group, the UTIs were significantly fewer [10.8% vs. 25.8%, p = 0.04, with an age-standardized 12-month UTI history (p = 0.01)]. The Kaplan–Meier survival curves showed that the cranberry group experienced a longer time to first UTI than the placebo group (p = 0.04). Biochemical parameters were normal, and there was no significant difference in urinary phenolics between the groups at baseline or on day180. The results show that cranberry fruit powder (peel, seeds, pulp) may reduce the risk of symptomatic UTI in women with a history of recurrent UTIs. Copyright © 2015 John Wiley & Sons, Ltd.
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