3,4,5-Tricaffeoylquinic Acid Attenuates TRAIL-induced Apoptosis in Human Keratinocytes by Suppressing Apoptosis-related Protein Activation
Da Hee Lee
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Search for more papers by this authorYoon Jeong Nam
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Search for more papers by this authorMin Sung Lee
Department of Internal Medicine, Soon Chun Hyang University Hospital, Bucheon City, Kyung-Gi-Do, 420-767 South Korea
Search for more papers by this authorDong Suep Sohn
Department of Thoracic and Cardiovascular Surgery, Chung-Ang University Hospital, Seoul, 156-755 South Korea
Search for more papers by this authorYong Kyoo Shin
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Search for more papers by this authorCorresponding Author
Chung Soo Lee
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Correspondence to: Chung Soo Lee, Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156-756, South Korea.
E-mail: [email protected]
Search for more papers by this authorDa Hee Lee
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Search for more papers by this authorYoon Jeong Nam
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Search for more papers by this authorMin Sung Lee
Department of Internal Medicine, Soon Chun Hyang University Hospital, Bucheon City, Kyung-Gi-Do, 420-767 South Korea
Search for more papers by this authorDong Suep Sohn
Department of Thoracic and Cardiovascular Surgery, Chung-Ang University Hospital, Seoul, 156-755 South Korea
Search for more papers by this authorYong Kyoo Shin
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Search for more papers by this authorCorresponding Author
Chung Soo Lee
Department of Pharmacology, College of Medicine, and the BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea
Correspondence to: Chung Soo Lee, Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156-756, South Korea.
E-mail: [email protected]
Search for more papers by this authorAbstract
Caffeoyl derivatives exhibit antiinflammatory and antioxidant effects. However, the effect of 3,4,5-tricaffeoylquinic acid on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in keratinocytes that may be involved in skin diseases has not been studied. In this respect, we investigated the effect of 3,4,5-tricaffeoylquinic acid on TRAIL-induced apoptosis in human keratinocytes. 3,4,5-Tricaffeoylquinic acid and oxidant scavengers attenuated the decrease in the cytosolic levels of Bid, Bcl-2, and survivin proteins; the increase in the levels of cytosolic Bax, p53, and phosphorylated p53; the increase in the levels of phosphorylated p38; the increase in the mitochondrial levels of the voltage-dependent anion channel; loss of the mitochondrial transmembrane potential; the release of cytochrome c; activation of caspases (8, 9, and 3); cleavage of poly [ADP-ribose] polymerase-1; production of reactive oxygen species; the depletion of glutathione (GSH); nuclear damage; and cell death in keratinocytes treated with TRAIL. These results suggest that 3,4,5-tricaffeoylquinic acid may reduce TRAIL-induced apoptosis in human keratinocytes by suppressing the activation of the caspase-8 and Bid pathways and the mitochondria-mediated cell death pathway. The effect appears to be associated with the inhibitory effect on the production of reactive oxygen species and depletion of GSH. 3,4,5-Tricaffeoylquinic acid appears to be effective in the prevention of TRAIL-induced apoptosis-mediated skin diseases. Copyright © 2015 John Wiley & Sons, Ltd.
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