3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice
Jackson R. G. S. Almeida
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorJuliane C. Silva
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorAmanda L. Guimarães
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorAna P. Oliveira
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorGrasielly R. Souza
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorRaimundo G. Oliveira-Júnior
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorSarah R. G. Lima-Saraiva
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorJosé M. Barbosa-Filho
Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Search for more papers by this authorRaimundo Braz-Filho
Departament of Chemistry of Natural Products, State University of North Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil
Search for more papers by this authorDinalva Brito Queiroz
Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil
Search for more papers by this authorCorresponding Author
Marco Antônio Botelho
Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil
Correspondence to: Prof. Marco A. Botelho, University Potiguar-UNP School of Health, Post graduation Program in Biotechnology. Av. Salgado Filho, 1610 -59056000 Natal- RN. Brazil.
E-mail: [email protected]
Search for more papers by this authorJackson R. G. S. Almeida
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorJuliane C. Silva
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorAmanda L. Guimarães
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorAna P. Oliveira
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorGrasielly R. Souza
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorRaimundo G. Oliveira-Júnior
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorSarah R. G. Lima-Saraiva
Centre for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil
Search for more papers by this authorJosé M. Barbosa-Filho
Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Search for more papers by this authorRaimundo Braz-Filho
Departament of Chemistry of Natural Products, State University of North Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil
Search for more papers by this authorDinalva Brito Queiroz
Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil
Search for more papers by this authorCorresponding Author
Marco Antônio Botelho
Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil
Correspondence to: Prof. Marco A. Botelho, University Potiguar-UNP School of Health, Post graduation Program in Biotechnology. Av. Salgado Filho, 1610 -59056000 Natal- RN. Brazil.
E-mail: [email protected]
Search for more papers by this authorAbstract
Lonchocarpus araripensis Benth. is largely distributed in the northeast region of Brazil. It is popularly known as ‘sucupira’. Recent studies have shown that some species of Lonchocarpus have interesting pharmacological activities. In this study, we evaluated the antinociceptive effect of a flavone isolated from L. araripensis. The chemical examination resulted in the isolation of 3,6-dimethoxy-6″,6″-dimethyl-(7,8,2″,3″)-chromeneflavone (DDF). The structure of the compound was established by spectral analysis. Antinociceptive activity of DDF was evaluated by measuring nociception by acetic acid, formalin and hot plate tests. The rota rod test was used to evaluate motor coordination. The results demonstrated that DDF was able to prevent acetic-acid-writhing-induced nociception (p < 0.001) in mice. Furthermore, DDF produced a significant reduction of the nociceptive behaviour at the early and late phases of paw licking in the formalin test. Also, DDF produced an inhibition of the nociceptive behaviour during a hot-plate test. No alteration in motor coordination was observed. These results confirm the hypothesis that DDF reduces the nociceptive behaviour in mice, probably through central mechanisms, but without compromising the motor coordination of animals. Copyright © 2015 John Wiley & Sons, Ltd.
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