Review
A Review of the Efficacy and Safety of Banaba (Lagerstroemia speciosa L.) and Corosolic Acid
Sidney J. Stohs,
Howard Miller, Gilbert R. Kaats,
Corresponding Author
Sidney J. Stohs
Creighton University, Medical Center, Omaha, NE 68178 USA
Dr Sidney J. Stohs, 4967 Stillwater Trail, Frisco, TX 75034, USA.
E-mail: [email protected]
Search for more papers by this authorGilbert R. Kaats
Integrative Health Technologies, San Antonio, TX 78209 USA
Search for more papers by this authorSidney J. Stohs,
Howard Miller, Gilbert R. Kaats,
Corresponding Author
Sidney J. Stohs
Creighton University, Medical Center, Omaha, NE 68178 USA
Dr Sidney J. Stohs, 4967 Stillwater Trail, Frisco, TX 75034, USA.
E-mail: [email protected]
Search for more papers by this authorGilbert R. Kaats
Integrative Health Technologies, San Antonio, TX 78209 USA
Search for more papers by this authorAbstract
Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic effects of banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects and in vitro systems using water soluble banaba leaf extracts, corosolic acid-standardized extracts, and purified corosolic acid and ellagitannins. Pure corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral, antineoplastic and osteoblastic activities. The beneficial effects of banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis and the regulation of lipid metabolism. These effects may be mediated by PPAR, MAP K, NF-κB and other signal transduction factors. No adverse effects have been observed or reported in animal studies or controlled human clinical trials. Banaba extract, corosolic acid and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits. Copyright © 2011 John Wiley & Sons, Ltd.
REFERENCES
- Aguirre MC, Delporte C, Backhouse N, et al. 2006. Topical anti-inflammatory activity of 2-alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorg Med Chem 14: 5673–5677.
- Bai N, He K, Roller M, et al. 2008. Active compounds from Lagerstroemia speciosa, insulin-like glucose uptake-stimulatory/inhibitory and adipocyte differentiation-inhibitory activities in 3T3L1 cells. J Agric Food Chem 56: 11668–11674.
- Banno N, Akihisa T, Tokuda H, et al. 2004. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and anti-tumor promoting effects. Biosci Biotechnol Biochem 68: 85–90.
- Choi HJ, Bae EY, Song JH, Baek SH, Kwon DH. 2010. Inhibitory effects of orobol-7-O-d-glucoside from banaba (Lagerstroemia speciosa L.) on human rhinoviruses replication. Lett Appl Microbiol 51: 1–5.
- Deocaris CC, Aguinaldo RR, dela Ysla JL, Asencion AS, Mojica ERE. 2005. Hypoglycemic activity of irradiated banaba (Lagerstroemia speciosa L.) leaves. J Appl Sci Res 1: 95–98.
- Fujiwara Y, Komohara Y, Ikeda T, Takeya M. 2011. Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear-factor kappa B in tumor cells and tumor-associated macrophages. Cancer Sci 102: 206–211.
- Fukushima M, Matsuyama F, Ueda N, et al. 2006. Effects of corosolic acid on post-challenge plasma glucose levels. Diab Res Clin Pract 73: 174–177.
- Garcia F. 1940. On the hypoglycemic effect of a decoction of Lagerstroemia speciosa leaves (banaba) administered orally. J Phil Med Assoc 20: 193–201.
- Garcia F. 1941. Distribution and deterioration of insulin-like principle in Lagerstroemia speciosa (banaba). Acta Med Phil 3: 99–104.
- Hattori K, Sukenobu N, Sasaki T, et al. 2003. Activation of insulin receptors by lagerstroemin. J Pharmacol Sci 93: 69–73.
- Hayashi T, Maruyama H, Kasai R, et al. 2002. Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells. Planta Med 68: 173–175.
- Hong H, Maeng WJ. 2004. Effects of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice. J Med Food 7: 487–490.
- Hosoyama H, Sugimoto A, Suzuki Y, Sakane I, Kakuda T. 2003. Isolation and quantitative analysis of the α-amylase inhibitor in Lagerstroemia speciosa (L.) Pers. (banaba) (In Japanese). Yakugaku Zasshi 123: 599–605.
- Hou W, Li Y, Zhang Q, et al. 2009. Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors. Phytother Res 23: 614–618.
- Hu C, Chen L, Xin Y, Cai Q. 2006. Determination of corosolic acid in Eriobotrya japonica leaves by reversed-phase high performance liquid chromatography (In Chinese). Se Pu 24: 492–494.
- Ichikawa H, Yagi H, Tanaka T, Cyong JC, Masaki T. 2010. Lagerstroemia speciosa extract inhibit TNF-induced activation of nuclear factor-κB in rat cardiomyocyte H9c2 cells. J Ethnopharmacol 128: 254–256.
- Ikeda Y, Chen JT, Matsuda T. 1999. Effectiveness and safety of banabamin tablet containing extract from banaba in patients with mild type 2 diabetes (In Japanese). Jpn Pharmacol Ther 27: 829–835.
- Ikeda Y, Noguchi M, Kishi S, et al. 2002. Blood glucose controlling effects and safety of single and long-term administration on the extract of banaba leaves (In Japanese). J Nutr Food 5: 41–53.
- Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YMA, Passwater R. 2003. Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in type II diabetics: A dose-dependence study. J Ethnopharmacol 87: 115–117.
- Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyangi M. 1996. Hypoglycemic effect of extracts of Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem 60: 204–208.
- Kang SH, Shi YQ, Yang CX. 2008. Terpenoids and steroids of root of Rubus biflorus (In Chinese). Zhong Yao Cai 31: 1669–1671.
- Kim DH, Han KM, Chung IS, et al. 2005. Triterpenoids from the flower of the Campsis grandiflora K. Schum as human acyl CoA:cholesterol acyltransferase inhibitors. Arch Pharmacol Res 28: 550–556.
- Kim E, Sy-Cordero A, Graf TN, Brantley SJ, Paine MF, Oberlies NH. 2011. Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. Planta Med 77: 265–270.
- Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. 2007. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evid Based Complement Alternat Med 4: 401–407.
- Lee MS, Cha EY, Thuong PT, Kim JY, Ahn MS, Sul JY. 2010a. Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. Biol Pharm Bull 33: 931–937.
- Lee MS, Lee CM, Cha EY, et al. 2010b. Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis. Phytother Res 24: 1857–1861.
- Lee MS, Thuong PT. 2010. Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytother Res 24: 49–53.
- Li Y, Kim J, Li J, et al. 2005. Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloyl-D-glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway. Biochem Biophys Res Comm 336: 430–437.
-
Lieberman S,
Spahrs R,
Stanton A,
Martinez L,
Grinder M. 2005. Weight loss, body measurements, and compliance: a 12-week total lifestyle intervention pilot study. Altern Compl Ther Dec: 307–313.
10.1089/act.2005.11.307 Google Scholar
- Liu F, Kim JK, Li Y, Liu XQ, Li J, Chen X. 2001. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr 131: 2242–2247.
- Liu P, Deng R, Duan H, Yin W. 2009. Chemical constituents from roots of Phlomis umbrosa (In Chinese). Zhongguo Zhong Yao Za Zhi 34: 867–870.
- Lu H, Chen J, Li WL, Zhang HQ. 2008. Studies on the triterpenes from ioquat leaf (Eriobotrya japonica) (In Chinese). Zhang Yao Cai 31: 1351–1354.
- Lu H, Xi C, Chen J, Li W. 2009. Determination of triterpenoid acids in leaves of Eriobotrya japonica collected at different seasons (In Chinese). Zhongguo Zhong Yao Za Zhi 34: 2353–2355.
- Matsuura T, Yoshikawa Y, Masui H, Sano M. 2004. Suppression of glucose absorption by various health teas in rats (In Japanese). Yakugaku Zasshi 124: 217–223.
- Miura T, Itoh Y, Kaneko T, et al. 2004. Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biol Pharm Bull 27: 1103–1105.
- Miura T, Ueda N, Yamada K, et al. 2006. Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Biol Pharm Bull 29: 585–587.
- Morshed A, Hossain MH, Shakil S, et al. 2010. Evaluation of the antinociceptive activity of two Bangladeshi medicinal plants, Kalanchoe pinnata (Lam.) Pers. and Lagerstroemia speciosa (L.) Pers. Adv Nat Appl Sci 4: 193–197.
- Musabayane CT, Tufts MA, Mapanga RF. 2010. Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. Ren Fail 32: 832–839.
- Na M, Yang S, He L, et al. 2006. Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata. Planta Med 72: 261–263.
- Nagai M, Fukamachi T, Tsujimoto M, et al. 2009. Inhibitory effects of herbal extracts on the activity of human sulfotransferase isoform sulfotransferase 1A3 (SULT1A3). Biol Pharm Bull 32: 105–109.
- Park C, Lee JS. 2011. Banaba: The natural remedy as antidiabetic drug. Biomed Res 22: 127–131.
- Park MY, Lee KS, Sung MK. 2005. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-α, PPAR-γ, and LPL mRNA expressions. Life Sci 77: 3344–3354.
- Rollinger JM, Kratschmar DV, Schuster D, et al. 2010. 11-Beta-hydroxysteroid dehydrogenase-1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorg Med Chem 18: 1507–1515.
- Saha BK, Bhuiyan NH, Mazumder K, Haque KMF. 2009. Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: underlying mechanism of action. J Bangladesh Pharmacol Soc 4: 79–83.
- Sato J, Goto K, Nanjo F, Kawai S, Murata K. 2000. Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola. J Biosci Bioeng 90: 442–446.
- Saumya SM, Basha PM. 2011. Antioxidant effect of Lagerstroemia speciosa Pers (banaba) leaf extract in streptozotocin-induced diabetic mice. Indian J Exp Biol 49: 125–131.
- Shen Y, Wang QH, Lin HW, Shu W, Zhou JB, Li ZY. 2006. Study on chemical constituents of Potentilla chinensis Ser (In Chinese). Zhong Yao Cai 29: 237–239.
- Shi L, Zhang W, Zhou YY, et al. 2008. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. Eur J Pharmacol 584: 21–29.
- Shim KS, Lee SU, Ryu SY, Min YK, Kim SH. 2009. Corosolic acid stimulates osteoblast differentiation by activating transcription factors and MAP kinases. Phytother Res 23: 1754–1758.
- Suzuki Y, Hayashi K, Sukabe I, Kakuda T. 2001. Effects and mode of action of banaba (Lagerstroemia speciosa L.) leaf extracts on postprandial blood glucose in rats. J Jpn Soc Nutr Food Sci 54: 131–137.
- Takagi S, Miura T, Ishibashi C, et al. 2008. Effect of corosolic acid on the hydrolysis of disaccharides. J Nutr Sci Vitaminol 54: 266–268.
- Takagi S, Miura T, Ishihara E, Ishida T, Chinzei Y. 2010. Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic rats. Biomed Res 31: 213–218.
- Tanaka T, Tong HH, Xu YM, Ishimaru K, Nonaka G, Nisioka I. 1992. Tannins and related compounds. CXVII. Isolation and characterization of three new ellagitannins, Lagerstannins A, B, and C, having a gluconic acid core, from Lagerstroemia speciosa (L.) Pers. Chem Pharm Bull 40: 2975–2980.
- Tanquilut NC, Tanquilut MRC, Estacio MAC, Torres EB, Rosario JC, Reyes BAS. 2009. Hypoglycemic effect of Lagerstroemia speciosa L. Pers. on alloxan-induced diabetic mice. J Med Plant Res 3: 1066–1071.
- Thuong PT, Min BS, Jin W, et al. 2006. Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biol Pharm Bull 29: 830–833.
- Thuppia A, Rabintossaporn P, Saenthaweesuk S, Ingkaninan K, Sireeratawong S. 2009. The hypoglycemic effect of a water extract from leaves of Lagerstroemia speciosa L. in streptozotocin-induced diabetic rats. Songklanakarin J Sci Technol 31: 133–137.
-
Tsuchibe S,
Kataumi S,
Mori M,
Mori H. 2006. An inhibitory effect on the increase in the postprandial glucose by banaba extract capsule enriched corosolic acid. J Integr Study Diet Habits 17: 255–259.
10.2740/jisdh.17.255 Google Scholar
- Ulbricht C, Dam C, Milkin T, Seamon E, Weissner W, Woods J. 2007. Banaba (Lagerstroemia speciosa L.): An evidence-based systematic review by the natural Standard Research Collaboration. J Herb Pharmacother 7: 99–113.
- Unno T, Sakane I, Masumizu T, Kohno M, Kakuda T. 1997. Antioxidant activity of water extracts of Lagerstroemia speciosa leaves. Biosci Biotechnol Biochem 61: 1772–1774.
- Vijaykumar K, Murthy PB, Kannababu S, Syamasundar B, Subbaraju GV. 2006. Quantitative determination of corosolic acid in Lagerstroemia speciosa leaves, extracts and dosage forms. Int J Appl Sci Eng 4: 103–114.
- Xu Y, Ge R, Du J, et al. 2009. Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells. Cancer Lett 284: 229–237.
- Yamada K, Hogokowa M, Fujimoto S, et al. 2008b. Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res Clin Pract 80: 48–55.
- Yamada K, Hosokawa M, Yamada C, et al. 2008a. Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biol Pharm Bull 31: 651–655.
- Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. 2006. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/HDmcr-cp rats, a model of metabolic syndrome. Life Sci 79: 2474–2479.
- Yang NY, Duan JA, Li P, Qian SH. 2006. Chemical constituents of Glechoma longituba (In Chinese). Yao Xue Xue Bao 41: 431–434.
- Zheng JQ, Zheng CM, Lu KC. 2010. Corosolic acid-induced acute kidney injury and lactic acidosis in a patient with impaired kidney function. Am J Kidney Dis 56: 419–420.
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