Effects of deltamethrin on ventral nerve cord activity in the cockroach†
Based on a poster presented at the symposium Neuropharmacology and pesticide action (Neurotox '85) on 31 March to 4 April 1985, organised by the Pesticide Group and the Physiocochemical and Biophysical Panel, Society of Chemical Industry.
Abstract
The effects of varying concentrations of deltamethrin on a number of the parameters of electrophysiological activity in the cockroach ventral nerve cord have been studied. Deltamethrin, at concentrations greater than 100 nM, caused repetitive firing in the central nervous system (CNS), prior to conduction block, the effect getting faster as the concentration was increased. Whilst 10-nM deltamethrin eventually caused conduction block with no apparent increase in the level of CNS activity, it induced a gradual decrease in the amplitudes of all spike activity. Deltamethrin at 10μM induced a significant increase in the latency of electrically evoked responses, and this was attributed to a synaptic mechanism. It was shown for the first time that 10-μM deltamethrin causes a significant elevation of the extra-axonal K+ activity; the possible consequences of this are discussed.
