Volume 57, Issue 1 pp. 308-310
CASE REPORT
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Successful whole lung lavage in a child with pulmonary alveolar proteinosis secondary to hematologic malignancy

Katharine Tsukahara MD

Corresponding Author

Katharine Tsukahara MD

Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Correspondence Katharine Tsukahara, MD, Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, 3501 Civic Center Blvd, 11th Floor, Philadelphia, PA 19104, USA.

Email: [email protected]

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Robert B. Lindell MD

Robert B. Lindell MD

Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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Haley Newman MD

Haley Newman MD

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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Benjamin J. Lerman MD, MS

Benjamin J. Lerman MD, MS

Division of General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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Leslie S. Kersun MD, MSCE, MSEd

Leslie S. Kersun MD, MSCE, MSEd

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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Joseph Piccione DO, MS

Joseph Piccione DO, MS

Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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First published: 13 October 2021
Citations: 1

Abstract

Pulmonary alveolar proteinosis (PAP) describes the accumulation of surfactant in the alveolar space. Secondary PAP has been reported in a variety of diseases, and in rare cases has been associated with hematologic malignancy. Treatment for PAP is based on the underlying disease process, and may include whole lung lavage, inhaled or subcutaneous granulocyte-macrophage colony-stimulating factor, or statins. PAP secondary to hematologic malignancy has been reported to demonstrate poor response to whole lung lavage. We report a case of successful treatment of a pediatric patient with acute myeloid leukemia and secondary PAP using whole lung lavage.

CONFLICT OF INTERESTS

The authors declare that there are no conflict of interests.

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