Safety and efficacy of plasma-activated water on prolonged viral shedding of COVID-19 patients: A randomized controlled trial
Xiaoya Guo
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorXing Lv
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorYunfu Wu
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorMingming Wang
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorShuo Wu
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorLi Guo
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorZifeng Wang
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorZhihong Shi
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorRui Huang
Department of Gastroenterology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China
Search for more papers by this authorHua Zhang
Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, Baoji, China
Search for more papers by this authorXiaona Niu
Department of Cardiology, Tangdu Hospital, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorMingzhe Rong
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorCorresponding Author
Liqiang Song
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Correspondence Liqiang Song, Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an 710032, China.
Email: [email protected]
Dingxin Liu, State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an 710049, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dingxin Liu
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Correspondence Liqiang Song, Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an 710032, China.
Email: [email protected]
Dingxin Liu, State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an 710049, China.
Email: [email protected]
Search for more papers by this authorXiaoya Guo
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorXing Lv
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorYunfu Wu
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorMingming Wang
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorShuo Wu
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorLi Guo
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorZifeng Wang
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorZhihong Shi
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorRui Huang
Department of Gastroenterology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China
Search for more papers by this authorHua Zhang
Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, Baoji, China
Search for more papers by this authorXiaona Niu
Department of Cardiology, Tangdu Hospital, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China
Search for more papers by this authorMingzhe Rong
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorCorresponding Author
Liqiang Song
Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, China
Correspondence Liqiang Song, Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an 710032, China.
Email: [email protected]
Dingxin Liu, State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an 710049, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Dingxin Liu
State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, China
Correspondence Liqiang Song, Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an 710032, China.
Email: [email protected]
Dingxin Liu, State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an 710049, China.
Email: [email protected]
Search for more papers by this authorXiaoya Guo and Xing Lv contributed equally to this study.
This study is registered with the Chinese Clinical Trials Registry (Registration No. ChiCTR2200056562).
Abstract
Shortening the duration of the viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to controlling viral transmission, alleviating the burden on the healthcare system, and ultimately mitigating the impact of the pandemic. This randomized, single-blind, placebo-controlled clinical trial aimed to investigate the safety and efficacy of gargling with plasma-activated water (PAW) on prolonged viral shedding in patients infected with SARS-CoV-2 Delta and Omicron variants. Sixty-two subjects, aged 18–80 years and infected with SARS-CoV-2, were recruited at two coronavirus disease 2019 (COVID-19)-designated hospitals in Shaanxi from January to March 2022. Primary outcomes included cumulative conversion rates, incidence of adverse reactions, and biosafety parameters. Results suggested that PAW gargling treatment might contribute to reducing the duration of SARS-CoV-2 Delta and Omicron variant infections and alleviating symptoms.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| ppap202300195-sup-0001-Supplementary_Figure_1.jpg384.4 KB | Supplementary Figure 1. Impact of PAW on the three-day conversion rate in COVID-19 Delta patients analyzed by Cox regression. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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