Cancer-targeting carbon quantum dots synthesized by plasma electrochemical method for red-light-activated photodynamic therapy
Ruoyu Wang
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorJiayan Shen
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYupengxue Ma
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorXiaoru Qin
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorXing Qin
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorFeng Yang
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorKostya (Ken) Ostrikov
School of Chemistry and Physics, Centre for Materials Science, and Centre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, Queensland, Australia
Search for more papers by this authorCorresponding Author
Qing Zhang
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Correspondence Qing Zhang and Xiaoxia Zhong, State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Email: [email protected] and [email protected]
Jie He, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Jie He
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence Qing Zhang and Xiaoxia Zhong, State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Email: [email protected] and [email protected]
Jie He, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Xiaoxia Zhong
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Correspondence Qing Zhang and Xiaoxia Zhong, State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Email: [email protected] and [email protected]
Jie He, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.
Email: [email protected]
Search for more papers by this authorRuoyu Wang
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorJiayan Shen
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYupengxue Ma
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorXiaoru Qin
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Search for more papers by this authorXing Qin
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorFeng Yang
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorKostya (Ken) Ostrikov
School of Chemistry and Physics, Centre for Materials Science, and Centre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, Queensland, Australia
Search for more papers by this authorCorresponding Author
Qing Zhang
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Correspondence Qing Zhang and Xiaoxia Zhong, State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Email: [email protected] and [email protected]
Jie He, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Jie He
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence Qing Zhang and Xiaoxia Zhong, State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Email: [email protected] and [email protected]
Jie He, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Xiaoxia Zhong
State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
Correspondence Qing Zhang and Xiaoxia Zhong, State Key Laboratory of Advanced Optical Communication Systems and Networks, Key Laboratory for Laser Plasmas (Ministry of Education), School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.
Email: [email protected] and [email protected]
Jie He, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.
Email: [email protected]
Search for more papers by this authorRuoyu Wang and Jiayan Shen have contributed equally to this study.
Abstract
Cancer-targeting carbon quantum dots (CQDs) with red-light absorption/emission featuring inherent biological functionality and deep biological penetration depth are promising for biomedical applications. However, traditional high-temperature and high-pressure synthesis processes result in unpredictable functionalities and uncontrollable optical properties due to the functional group loss. Here, plasma electrochemical treatment is introduced to overcome this issue. The synthesized CQDs in this work have excellent folate receptor cancer-targeting ability, red-light absorption/emission, and pronounced photodynamic therapy effect. The CQDs produced by the plasma electrochemical method preserve most of the functional groups from precursors, thus making them to fully inherit the bio-functionality and photophysical properties of precursors. This work opens new opportunities for plasma-based processes to controllably synthesize functionalized CQDs for diverse biomedical and environmental applications.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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| ppap202300174-sup-0001-Supporting_Information_1.docx392.7 KB | Supporting information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1a) L. Ðorđević, F. Arcudi, M. Cacioppo, M. Prato, Nat. Nanotechnol. 2022, 17, 112–130 b) N. Gong, X. Ma, X. Ye, Q. Zhou, X. Chen, X. Tan, S. Yao, S. Huo, T. Zhang, S. Chen, X. Teng, X. Hu, J. Yu, Y. Gan, H. Jiang, J. Li, X. J. Liang, Nat. Nanotechnol. 2019, 14, 379–387 c) J.-S. Yang, D. Z. Pai, W.-H. Chiang, Carbon 2019, 153, 315-319 d) Q. Zhang, F. Wang, R. Wang, J. Liu, Y. Ma, X. Qin, X. Zhong, Adv. Sci. 2023, 10, e2207566 e) Q. Zhang, R. Wang, B. Feng, X. Zhong, K. Ostrikov, Nat. Commun. 2021, 12, 6856.
- 2a) S. Li, J. Jiang, Y. Yan, P. Wang, G. Huang, N. Kim, J. H. Lee, D. He, Mater. Sci. Eng. C. 2018, 93, 1054–1063
b) S. Li, W. Su, H. Wu, T. Yuan, C. Yuan, J. Liu, G. Deng, X. Gao, Z. Chen, Y. Bao, F. Yuan, S. Zhou, H. Tan, Y. Li, X. Li, L. Fan, J. Zhu, A. T. Chen, F. Liu, Y. Zhou, M. Li, X. Zhai, J. Zhou, Nat. Biomed. Eng. 2020, 4, 704-716
c) Q. Zhang, S. Deng, J. Liu, X. Zhong, J. He, X. Chen, B. Feng, Y. Chen, K. Ostrikov, Adv. Funct. Mater. 2018, 29, 1805860, https://doi.org/10.1002/adfm.201805860
10.1002/adfm.201805860 Google Scholard) M. Zheng, S. Ruan, S. Liu, T. Sun, D. Qu, H. Zhao, Z. Xie, H. Gao, X. Jing, Z. Sun, ACS Nano 2015, 9, 11455–11461.
- 3a) P. J. Bruggeman, M. J. Kushner, B. R. Locke, J. G. E. Gardeniers, W. G. Graham, D. B. Graves, R. C. H. M. Hofman-Caris, D. Maric, J. P. Reid, E. Ceriani, D. Fernandez Rivas, J. E. Foster, S. C. Garrick, Y. Gorbanev, S. Hamaguchi, F. Iza, H. Jablonowski, E. Klimova, J. Kolb, F. Krcma, P. Lukes, Z. Machala, I. Marinov, D. Mariotti, S. Mededovic Thagard, D. Minakata, E. C. Neyts, J. Pawlat, Z. L. Petrovic, R. Pflieger, S. Reuter, D. C. Schram, S. Schröter, M. Shiraiwa, B. Tarabová, P. A. Tsai, J. R. R. Verlet, T. von Woedtke, K. R. Wilson, K. Yasui, G. Zvereva, Plasma Sources Sci. Technol. 2016, 25 b) W. H. Chiang, D. Mariotti, R. M. Sankaran, J. G. Eden, K. K. Ostrikov, Adv. Mater. 2020, 32, e1905508.
- 4K. Kim, C. Chokradjaroen, N. Saito, Nano Express 2020, 1, 020043.
10.1088/2632-959X/abb9fa Google Scholar
- 5D. Kurniawan, B. A. Anjali, O. Setiawan, K. K. Ostrikov, Y. G. Chung, W. H. Chiang, ACS Appl. Mater. Interfaces 2022, 14, 1670.
- 6a) X. Qin, J. Liu, Q. Zhang, W. Chen, X. Zhong, J. He, Nanoscale Res. Lett. 2021, 16, 14 b) Q. Wang, Q. Zhang, Y. Chen, J. He, K. Jiang, Z. Hu, X. Zhong, Plasma Processes Polym. 2018, 15, e1700088.
- 7a) J. Amaro-Gahete, M. Mora, P. Gutiérrez, D. Cosano, D. Esquivel, J. R. Ruiz, C. Jiménez-Sanchidrián, M. C. García, F. J. Romero-Salguero, J. Phys. D: Appl. Phys. 2020, 53, 435202
b) C. B. Ke, T. L. Lu, J. L. Chen, Mikrochim. Acta 2019, 186, 376
c) X. Ma, S. Li, V. Hessel, L. Lin, S. Meskers, F. Gallucci, Chem. Eng. Process. Process Intensif. 2019, 140, 29–35
d) X. Ma, S. Li, V. Hessel, L. Lin, S. Meskers, F. Gallucci, Chem. Eng. Sci. 2020, 220, 115648
e) M. Mohammadzaheri, V. Siahpoush, A. Asgari, Plasma Processes Polym. 2022, 19, e2200089
f) T. Orriere, D. Kurniawan, Y. C. Chang, D. Z. Pai, W. H. Chiang, Nanotechnology 2020, 31, 485001
g) J. Weerasinghe, J. Scott, A. D. K. Deshan, D. Chen, A. Singh, S. Sen, P. Sonar, K. Vasilev, Q. Li, K. Ostrikov, Adv. Mater. Technol. 2021, 7, 2100586
10.1002/admt.202100586 Google Scholarh) R. Zhou, R. Zhou, Y. Xian, Z. Fang, X. Lu, K. Bazaka, A. Bogaerts, K. Ostrikov, Chem. Eng. J. 2020, 382, 122745.
- 8Y. Y. He, X. C. Wang, P. K. Jin, B. Zhao, X. Fan, Spectrochim. Acta, Part A 2009, 72, 876.
- 9O. L. Gladkova, M. V. Parkhats, A. N. Gorbachova, S. N. Terekhov, Spectrochim. Acta, Part A 2010, 76, 388.
- 10A. Y. Lee, K. Yang, N. D. Anh, C. Park, S. M. Lee, T. G. Lee, M. S. Jeong, Appl. Surf. Sci. 2021, 536, 147990.
- 11a) M. Z. Fahmi, N. F. Sholihah, A. Wibrianto, S. C. W. Sakti, F. Firdaus, Chang, Mater. Chem. Phys. 2021, 267, 124596 b) M. Yu, X. Guo, H. Lu, P. Li, R. Huang, C. Xu, X. Gong, Y. Xiao, X. Xing, Carbon 2022, 199, 395–406 c) S. Yang, X. Wang, P. He, A. Xu, G. Wang, J. Duan, Y. Shi, G. Ding, Small 2021, 17, e2004867 d) W. Huang, Y. Huang, L. Yang, J. Li, C. Liu, N. Li, B. Lai, Chem. Eng. J. 2023, 465, 142911 e) Y. Toren, A. Vilan, N. Amdursky, Small 2023, 19, e2301371. https://doi.org/10.1002/smll.202301371
- 12a) Y. Liu, C. Zhu, Y. Gao, L. Yang, J. Xu, X. Zhang, C. Lu, Y. Wang, Y. Zhu, Appl. Surf. Sci. 2020, 510, 145437 b) M. K. Rabchinskii, S. D. Saveliev, D. Y. Stolyarova, M. Brzhezinskaya, D. A. Kirilenko, M. V. Baidakova, S. A. Ryzhkov, V. V. Shnitov, V. V. Sysoev, P. N. Brunkov, Carbon 2021, 182, 593–604.
- 13Q. H. Pho, L. Lin, N. N. Tran, T. T. Tran, A. H. Nguyen, D. Losic, E. V. Rebrov, V. Hessel, Carbon 2022, 198, 22.
- 14a) F. Olmo, A. Rodriguez, A. Colina, A. Heras, J. Solid State Electrochem. 2021, 26, 29–37 b) A. H. Thomas, C. Lorente, A. L. Capparelli, M. R. Pokhrel, A. M. Braun, E. Oliveros, Photochem. Photobiol. Sci. 2002, 1, 421–426.
- 15J. A. Ledermann, S. Canevari, T. Thigpen, Ann. Oncol. 2015, 26, 2034.
- 16C. Chen, J. Ke, X. E. Zhou, W. Yi, J. S. Brunzelle, J. Li, E. L. Yong, H. E. Xu, K. Melcher, Nature 2013, 500, 486.
- 17a) D. Chen, Q. Xu, W. Wang, J. Shao, W. Huang, X. Dong, Small 2021, 17, e2006742 b) Z. Zhou, J. Song, L. Nie, X. Chen, Chem. Soc. Rev. 2016, 45, 6597–6626.
- 18A. S. Wibowo, M. Singh, K. M. Reeder, J. J. Carter, A. R. Kovach, W. Meng, M. Ratnam, F. Zhang, C. E. Dann, 3rd, Proc. Natl. Acad. Sci. 2013, 110, 15180.
