Fatal encephalitis accompanied by ARDS in a child with HSV Infection
Lili Xu
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
These authors contributed equally to this work.Search for more papers by this authorJun Liu
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
These authors contributed equally to this work.Search for more papers by this authorYilin Pang
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Search for more papers by this authorXiaolei Guan
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Search for more papers by this authorSuyun Qian
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Search for more papers by this authorCorresponding Author
Zhengde Xie
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Correspondence
Zhengde Xie, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Hengmiao Gao, Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Hengmiao Gao
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Correspondence
Zhengde Xie, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Hengmiao Gao, Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Search for more papers by this authorLili Xu
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
These authors contributed equally to this work.Search for more papers by this authorJun Liu
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
These authors contributed equally to this work.Search for more papers by this authorYilin Pang
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Search for more papers by this authorXiaolei Guan
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Search for more papers by this authorSuyun Qian
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Search for more papers by this authorCorresponding Author
Zhengde Xie
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute , Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Correspondence
Zhengde Xie, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Hengmiao Gao, Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Hengmiao Gao
Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China
Correspondence
Zhengde Xie, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Hengmiao Gao, Department of Pediatric Critical Care Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Email: [email protected]
Search for more papers by this authorFunding source
This work was supported by grants from the National Major S & T Research Projects for the Control and Prevention of Major Infectious Diseases in China (2017ZX10103004-004, 2018ZX10003006-001-004), the National Natural Science Foundation of China (31370203), the Capital Health Research and Development of Special Projects (2016-2-1142), and Hospitals Foundation (QML20161201).
CONFLICT OF INTEREST
The authors have no potential conflicts of interest.
REFERENCES
- 1Pebody RG, Andrews N, Brown D, et al. The seroepidemiology of herpes simplex virus type 1 and 2 in Europe. Sex Transm Infect. 2004; 80: 185-191.
- 2Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001; 357: 1513-1518.
- 3Olson LC, Buescher EL, Artenstein MS, et al. Herpesvirus infections of the human central nervous system. N Engl J Med. 1967; 277: 1271-1277.
- 4Whitley RJ. Herpes simplex virus infections of the central nervous system. Continuum (Minneap Minn). 2015; 21(6 Neuroinfectious Disease): 1704-1713
- 5Czartoski T, Liu C, Koelle DM, et al. Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman. J Clin Microbiol. 2006; 44: 1584-1586.
- 6Feldman S, Stokes DC. Varicella zoster and herpes simplex virus pneumonias. Semin Respir Infect. 1987; 2: 84-94.
- 7Astuto M, Palermo CI, Costanzo CM, et al. Fatal pulmonary disease and encephalic complication in a man with HSV-1 Infection: a case report. J Clin Virol. 2014; 59: 59-62.
- 8Bruynseels P, Jorens PG, Demey HE, et al. Herpes simplex virus in the respiratory tract of critical care patients: a prospective study. Lancet. 2003; 362: 1536-1541.
- 9Luyt CE, Combes A, Deback C, et al. Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation. Am J Resp Crit Care. 2007; 175: 935-942.
- 10Warren KG, Brown SM, Wroblewska Z, et al. Isolation of latent herpes simplex virus from the superior cervical and vagus ganglions of human beings. N Engl J Med. 1978; 298: 1068-1069.
- 11Rimerio CA, De Oliveira RS, de Almeida Bonatelli MQ, et al. Human herpesvirus infections of the central nervous system: laboratory diagnosis based on DNA detection by nested PCR in plasma and cerebrospinal fluid samples. J Med Virol. 2015; 87: 648-655.
