Malignant gastrointestinal neuroectodermal tumor as a second malignancy following Ewing sarcoma: Diagnostic pitfalls in the EWSR1-rearranged tumor spectrum
Pierre Khneisser
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorMohamed-Amine Bani
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorSophie Cotteret
Department of Tumor Genetics, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorNizar Labaied
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorCharles Honore
Department of Surgery, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorPablo Berlanga
Department of Pediatric Oncology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorCorresponding Author
Jean-Yves Scoazec
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
Correspondence
Jean-Yves Scoazec, Department of Pathology, Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif cedex, France.
Email: [email protected]
Search for more papers by this authorPierre Khneisser
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorMohamed-Amine Bani
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorSophie Cotteret
Department of Tumor Genetics, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorNizar Labaied
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorCharles Honore
Department of Surgery, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorPablo Berlanga
Department of Pediatric Oncology, Gustave Roussy Cancer Campus, Villejuif, France
Search for more papers by this authorCorresponding Author
Jean-Yves Scoazec
Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
Correspondence
Jean-Yves Scoazec, Department of Pathology, Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif cedex, France.
Email: [email protected]
Search for more papers by this author
REFERENCES
- 1Stockman DL, Miettinen M, Suster S, et al. Malignant gastrointestinal neuroectodermal tumor: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of 16 cases with a reappraisal of clear cell sarcoma-like tumors of the gastrointestinal tract. Am J Surg Pathol. 2012; 36: 857-868.
- 2Wang J, Thway K. Clear cell sarcoma-like tumor of the gastrointestinal tract: an evolving entity. Arch Pathol Lab Med. 2015; 139: 407-412.
- 3Green C, Spagnolo DV, Robbins PD, Fermoyle S, Wong DD. Clear cell sarcoma of the gastrointestinal tract and malignant gastrointestinal neuroectodermal tumour: distinct or related entities? A review. Pathology. 2018; 50: 490-498.
- 4Chang B, Yu L, Guo WW, et al. Malignant gastrointestinal neuroectodermal tumor: clinicopathologic, immunohistochemical, and molecular analysis of 19 cases. Am J Surg Pathol. 2020; 44: 456-466.
- 5Kandler T, Cortez E, Clinton L, et al. A case series of metastatic malignant gastrointestinal neuroectodermal tumors and comprehensive genomic profiling analysis of 20 cases. Curr Oncol. 2022; 29: 1279-1297.
- 6Flucke U, van Noesel MM, Siozopoulou V, et al. EWSR1 - the most common rearranged gene in soft tissue lesions, which also occurs in different bone lesions: an updated review. Diagnostics (Basel). 2021; 11: 1093.
- 7Li R, Cao J, Chen L, et al. Malignant gastrointestinal neuroectodermal tumors: clinicopathological and prognostic features of 96 patients. Onco Targets Ther. 2020; 13: 9731-9740.
- 8Insabato L, Guadagno E, Natella V, et al. An unusual association of malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like) and Ewing sarcoma. Pathol Res Pract. 2015; 211: 688-692.
- 9Balkaransingh P, Saad SA, Govil SC, Thind PK, Ballance CM, Weiss AR. Clear cell sarcoma of the gastrointestinal tract presenting as a second malignant neoplasm following neuroblastoma in infancy. Pediatr Blood Cancer. 2012; 58: 481-482.
- 10Yang JC, Chou AJ, Oeffinger KC, La Quaglia MP, Wolden SL. Clear cell sarcoma of the gastrointestinal tract after very low-dose therapeutic radiation therapy: a case report. J Pediat Surg. 2012; 47: 1943-1945.
- 11Thway K, Judson I, Fisher C. Clear cell sarcoma-like tumor of the gastrointestinal tract, presenting as a second malignancy after childhood hepatoblastoma. Case Rep Med. 2014; 2014:984369.
- 12Libertini M, Thway K, Noujaim J, et al. Clear cell sarcoma-like tumor of the gastrointestinal tract: clinical outcome and pathologic features of a molecularly characterized tertiary center case series. Anticancer Res. 2018; 38: 1479-1483.
- 13Zhan MN, Yu J, Luo RK, Hou YY. Malignant gastrointestinal neuroectodermal tumor, presenting as a second malignancy after gastric adenocarcinoma: a case report and literature review. J Gastrointest Oncol. 2019; 10: 1144-1150.
- 14Zambrano E, Reyes-Mugica M, Franchi A, Rosai J. An osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: reports of 6 cases of a GIST simulator. Int J Surg Pathol. 2003; 11: 75-81.
- 15Venkataraman G, Quinn AM, Williams J, Hammadeh R. Clear cell sarcoma of the small bowel: a potential pitfall. Case report. APMIS. 2005; 113: 716-719.