Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study
Keyne Charlot PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorBerenike Moeckesch MSc
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorStéphane Jumet MSc
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorMarc Romana PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorXavier Waltz PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorLydia Divialle-Doumdo MD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorMarie-Dominique Hardy-Dessources PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorMarie Petras MD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorBenoît Tressières MSc
Centre Investigation Clinique Antilles Guyane 1424 Inserm, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorAurélien Pichon PhD
Laboratory MOVE, EA6314, University of Poitiers, Poitiers, France
Search for more papers by this authorVanessa Tarer PhD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorOlivier Hue PhD
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorMaryse Etienne-Julan MD, PhD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorSophie Antoine-Jonville PhD
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorCorresponding Author
Philippe Connes PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Institut Universitaire de France (IUF), Paris, France
Laboratory CRIS EA647, Section Vascular Biology and Red Blood Cell, University of Lyon, Lyon, France
Correspondence to: Philippe Connes, UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France. E-mail: [email protected]
Search for more papers by this authorKeyne Charlot PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorBerenike Moeckesch MSc
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorStéphane Jumet MSc
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorMarc Romana PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorXavier Waltz PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorLydia Divialle-Doumdo MD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorMarie-Dominique Hardy-Dessources PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Search for more papers by this authorMarie Petras MD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorBenoît Tressières MSc
Centre Investigation Clinique Antilles Guyane 1424 Inserm, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorAurélien Pichon PhD
Laboratory MOVE, EA6314, University of Poitiers, Poitiers, France
Search for more papers by this authorVanessa Tarer PhD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorOlivier Hue PhD
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorMaryse Etienne-Julan MD, PhD
Sickle Cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorSophie Antoine-Jonville PhD
Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Search for more papers by this authorCorresponding Author
Philippe Connes PhD
UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France
Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex) PRES Sorbonne, Paris, France
Institut Universitaire de France (IUF), Paris, France
Laboratory CRIS EA647, Section Vascular Biology and Red Blood Cell, University of Lyon, Lyon, France
Correspondence to: Philippe Connes, UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France. E-mail: [email protected]
Search for more papers by this authorAbstract
Background
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso-occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status of SCA patients remains unknown.
Procedure
Twenty-two patients with SCA and 15 healthy (AA) children/adolescents participated to the study. Heart rate variability was measured in supine position and after a tilt-test to quantify the ANS activity. PA energy expenditure (PAEE) was assessed with questionnaire.
Results
1) PAEE was lower in SCA compared to AA (190 ± 152 vs. 432 ± 277 kcal·d−1, respectively, P < 0.01), 2) overall ANS activity was lower in SCA compared to AA, 3) parasympathetic withdrawal was observed in SCA with aging, 4) ANS reactivity was slightly impaired in SCA compared to AA (reduction in HFnu: −38 ± 27 vs. −58 ± 14%, respectively, P < 0.05), 5) ANS indices, PAEE, and rates of clinical events were not correlated.
Conclusion
Both the level of PA and ANS activity are reduced in SCA compared to AA children/adolescents, particularly in those older than 15 years. Neither PAEE, nor ANS activity seem to influence the clinical severity of children/adolescents with SCA. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
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