Epidemiology of rhabdoid tumors of early childhood†
Corresponding Author
Julia E. Heck PhD, MPH
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Department of Epidemiology, Box 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772.===Search for more papers by this authorChristina A. Lombardi MPH
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorMyles Cockburn PhD
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California
Search for more papers by this authorTravis J. Meyers MPH
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorMichelle Wilhelm PhD
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorBeate Ritz PhD, MD
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorCorresponding Author
Julia E. Heck PhD, MPH
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Department of Epidemiology, Box 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772.===Search for more papers by this authorChristina A. Lombardi MPH
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorMyles Cockburn PhD
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California
Search for more papers by this authorTravis J. Meyers MPH
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorMichelle Wilhelm PhD
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorBeate Ritz PhD, MD
Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
Search for more papers by this authorConflicts of Interest: Nothing to declare.
Abstract
Background
Rhabdoid tumors are a rare and aggressive cancer subtype which is usually diagnosed in early childhood. Little is known about their etiology. The purpose of this study was to describe the epidemiology of rhabdoid tumors and examine their relation to perinatal characteristics.
Methods
We identified 44 atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system (CNS) and 61 rhabdoid sarcomas (renal and extra-renal non-CNS tumors) from California Cancer Registry records of diagnoses 1988–2007 among children <6 years of age. We randomly selected 208,178 controls from California birthrolls. Multivariable logistic regression was used to examine associations between rhabdoid tumors and perinatal characteristics.
Results
After adjustment for demographic characteristics, low birthweight (<2,500 g) strongly increased risk for developing both rhabdoid sarcomas (OR = 2.43, 95% CI 1.09, 5.41) and AT/RT (OR = 2.99, 95% CI 1.31, 6.84). Both preterm delivery (<37 weeks gestation, OR = 2.63, 95% CI 1.34, 5.17) and late term delivery (>42 weeks, OR = 3.66, 95% CI 1.54, 8.71) also increased risk of rhabdoid sarcomas. Rhabdoid sarcoma cases (OR = 3.08, 95% CI 1.11, 8.55) and AT/RT cases (OR = 3.16, 95% CI 1.23, 8.13) also were more likely to be multiple births.
Conclusion
The excess of twin pregnancies may suggest an association with infertility treatments. This is the first population-based epidemiologic study to examine these rare tumors. Pediatr Blood Cancer 2013; 60: 77–81. © 2012 Wiley Periodicals, Inc.
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