Successful pulmonary artery embolectomy in a patient with a saddle Wilms tumor embolus†
Corresponding Author
Lindsey Cooper MD
Section of Critical Care, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Critical Care, Mail Stop 8414, 13121 E. 17th Avenue, P.O. Box 6508, Aurora, Colorado 80045.===Search for more papers by this authorColin Moore MD
Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorBrian Branchford MD
Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorBrian Greffe MD
Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorKelley Capocelli MD
Section of Pathology, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorAustine Kuder MD
Section of General Pediatrics, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorInder Mehta MD
Section of Pediatric Cardiovascular Surgery, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorPeter M Mourani MD
Section of Critical Care, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorCorresponding Author
Lindsey Cooper MD
Section of Critical Care, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Critical Care, Mail Stop 8414, 13121 E. 17th Avenue, P.O. Box 6508, Aurora, Colorado 80045.===Search for more papers by this authorColin Moore MD
Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorBrian Branchford MD
Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorBrian Greffe MD
Center for Cancer and Blood Disorders, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorKelley Capocelli MD
Section of Pathology, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorAustine Kuder MD
Section of General Pediatrics, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorInder Mehta MD
Section of Pediatric Cardiovascular Surgery, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorPeter M Mourani MD
Section of Critical Care, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado
Search for more papers by this authorConflict of interest: Nothing to declare.
Abstract
Denys–Drash syndrome is a genetic disorder characterized by ambiguous genitalia, cryptorchidism, nephrotic syndrome, and a high predilection for Wilms tumor with intravascular invasion. We report a 5-year-old male with Denys–Drash syndrome who rapidly developed Wilms tumor with vascular invasion, subsequent saddle tumor embolus, and required emergent embolectomy. This case illustrates the rapid emergence of Wilms tumor in a patient with Denys–Drash syndrome and the importance of considering embolectomy over thrombolytic therapy for PE in this population, given a high likelihood of tumor embolus. Pediatr Blood Cancer 2012; 58: 806–809. © 2011 Wiley Periodicals, Inc.
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