Fabrication and characterization of composites composed of a bioresorbable polyester matrix and surface modified calcium carbonate whisker for bone regeneration
Jielin Wang
Department of Materials Science, Fudan University, Shanghai, 200433 China
Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France
Search for more papers by this authorCorresponding Author
Zhongyong Fan
Department of Materials Science, Fudan University, Shanghai, 200433 China
Correspondence to: Zhongyong Fan, Department of Materials Science, Fudan University, Shanghai 200433, China.
Suming Li, Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France.
Feng Su, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Suming Li
Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France
Correspondence to: Zhongyong Fan, Department of Materials Science, Fudan University, Shanghai 200433, China.
Suming Li, Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France.
Feng Su, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
E-mail: [email protected]
Search for more papers by this authorXue Liu
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China
Search for more papers by this authorXin Shen
College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China
Search for more papers by this authorCorresponding Author
Feng Su
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China
Correspondence to: Zhongyong Fan, Department of Materials Science, Fudan University, Shanghai 200433, China.
Suming Li, Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France.
Feng Su, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
E-mail: [email protected]
Search for more papers by this authorJielin Wang
Department of Materials Science, Fudan University, Shanghai, 200433 China
Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France
Search for more papers by this authorCorresponding Author
Zhongyong Fan
Department of Materials Science, Fudan University, Shanghai, 200433 China
Correspondence to: Zhongyong Fan, Department of Materials Science, Fudan University, Shanghai 200433, China.
Suming Li, Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France.
Feng Su, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Suming Li
Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France
Correspondence to: Zhongyong Fan, Department of Materials Science, Fudan University, Shanghai 200433, China.
Suming Li, Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France.
Feng Su, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
E-mail: [email protected]
Search for more papers by this authorXue Liu
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China
Search for more papers by this authorXin Shen
College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China
Search for more papers by this authorCorresponding Author
Feng Su
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China
Correspondence to: Zhongyong Fan, Department of Materials Science, Fudan University, Shanghai 200433, China.
Suming Li, Institut Européen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier Cedex 5, France.
Feng Su, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
E-mail: [email protected]
Search for more papers by this authorAbstract
This work aims to evaluate the potential of a bioresorbable composite as material for bone regeneration. Surface-modified calcium carbonate whiskers (CCWs) were prepared by grafting of ethylene glycol (EG) using 1,6-hexamethylene diisocyanate as coupling agent, followed by ring-opening polymerization of l-lactide initiated by the hydroxyl group of EG. The resulting PLLA-EG-g-CCW was used as filler to reinforce a bioresorbable terpolymer, poly(l-lactide-co-trimethylene carbonate-co-glycolide) (PLTG). The mechanical properties and thermal stability of the PLTG/PLLA-EG-g-CCW composites were greatly improved. Compared with neat PLTG, a 39.3% increase in tensile strength and 26.7% increase in elongation at break were obtained for the composite with 2 wt% PLLA-EG-g-CCW filler. This was assigned to the reinforcement effect of evenly dispersed PLLA-EG-g-CCW in the polymeric matrix. In fact, entanglement of PLLA grafts at the surface of PLLA-EG-g-CCW with PLTG chains results in a homogeneous distribution of the filler in the matrix. Thus, the composites are simultaneously strengthened and toughened. The cytocompatibility of the materials was evaluated from cell morphology and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay using L929 mouse fibroblast cell line. The results indicate that the composite presents very low cytotoxicity. Copyright © 2017 John Wiley & Sons, Ltd.
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