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Altered blood rheology in the pathogenesis of diabetic and other neuropathies
Dr. Leslie O. Simpson MSc, PhD,
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Dr. Leslie O. Simpson MSc, PhD
Pathology Department, University of Otago Medical School, Dunedin, New Zealand
Pathology Department, University of Otago Medical School, P.O. Box 913, Dunedin, New ZealandSearch for more papers by this authorDr. Leslie O. Simpson MSc, PhD,
Corresponding Author
Dr. Leslie O. Simpson MSc, PhD
Pathology Department, University of Otago Medical School, Dunedin, New Zealand
Pathology Department, University of Otago Medical School, P.O. Box 913, Dunedin, New ZealandSearch for more papers by this authorAbstract
Although a substantial literature confirms the abnormal flow properties of diabetic blood, only in a few papers has the vasculitis of diabetic neuropathy been considered to have a hemorheological cause. It is proposed that the pathogenesis of nerve lesions involves an interaction between the specialized nerve vascular system and focal ischemic lesions resulting from rheologically induced stasis. The proposition is extended into other conditions with abnormal blood rheology such as hypothyroidism, uremia, dysglobulinemia, polyarteritis nodosa, and lepromatous leprosy. It is concluded that the treatment of such polyneuropathies should include an agent which would improve the flow properties of the blood.
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