Adult nemaline myopathy with trabecular muscle fibers
Corresponding Author
Viktoriya S. Irodenko MD
Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USA
Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USASearch for more papers by this authorHan S. Lee MD, PhD
Department of Pathology, Neuropathology Unit, University of California School of Medicine, San Francisco, California, USA
Search for more papers by this authorStephen J. de Armond MD, PhD
Department of Pathology, Neuropathology Unit, University of California School of Medicine, San Francisco, California, USA
Search for more papers by this authorRobert B. Layzer MD
Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USA
Search for more papers by this authorCorresponding Author
Viktoriya S. Irodenko MD
Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USA
Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USASearch for more papers by this authorHan S. Lee MD, PhD
Department of Pathology, Neuropathology Unit, University of California School of Medicine, San Francisco, California, USA
Search for more papers by this authorStephen J. de Armond MD, PhD
Department of Pathology, Neuropathology Unit, University of California School of Medicine, San Francisco, California, USA
Search for more papers by this authorRobert B. Layzer MD
Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USA
Search for more papers by this authorAbstract
The term “trabecular myopathy” has been used to designate a syndrome resembling limb-girdle muscular dystrophy in which the predominant pathological feature is an abundance of lobulated or trabecular muscle fibers. However, the validity of this nosological entity has not been verified. Herein we describe a 63-year-old man with a severe, progressive myopathy who exhibited the typical pathological features of both trabecular myopathy and nemaline myopathy in association with a biclonal gammopathy. In this case, adult-onset nemaline myopathy was probably the primary disease process. The diagnostic significance of trabecular muscle fibers remains uncertain. Muscle Nerve, 2008
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