Looping Star
Corresponding Author
Florian Wiesinger
ASL Europe, GE Healthcare, Munich, Germany
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
Correspondence
Florian Wiesinger, GE Healthcare
Freisinger Landstrasse 50, 85748 Munich, Germany.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Florian Wiesinger
ASL Europe, GE Healthcare, Munich, Germany
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
Correspondence
Florian Wiesinger, GE Healthcare
Freisinger Landstrasse 50, 85748 Munich, Germany.
Email: [email protected]
Search for more papers by this authorAbstract
Purpose
To introduce a novel MR pulse sequence, termed Looping Star, for fast, robust, and yet quiet, 3D radial multi-gradient echo T2* MR imaging.
Methods
The Looping Star pulse sequence is based on the 3D radial Rotating Ultra-Fast Imaging Sequence (RUFIS) extended by a time-multiplexed gradient-refocusing mechanism. First, multiple magnetic coherences are excited, which are subsequently gradient-refocused in form of a looping k-space trajectory. Accordingly, Looping Star captures an initial FID image followed by gradient echo images at equidistant echo times.
Results
Looping Star was demonstrated in phantom and in vivo volunteer experiments for 3D, high resolution T2* weighted imaging, T2* mapping, and quantitative susceptibility mapping (QSM). The method is fast, quiet, and robust against imperfections including Eddy currents, motion, and geometric distortions. When applied to a motor task fMRI experiment a BOLD sensitivity of 5% was achieved at minimal acoustic noise (i.e. 2.7 dB(A) above ambient noise) and with images congruent to other anatomical scans.
Conclusions
Looping Star imaging provides new and exciting opportunities for fast, robust and yet quiet T2* MR imaging. Potential applications include T2*-weighted imaging, T2* mapping, QSM, and fMRI.
Supporting Information
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mrm27440-sup-0001-FigS1-S2.docxapplication/docx, 356.1 KB |
FIGURE S1 Schematic illustration of Looping Star assuming NSpkPerLoop = 6 and NLoop = 3 (i.e. 1 FID and 2 equidistantechoes). One single segment of the pulse sequence is illustrated in Fig. 1A. RF excitation block pulses (bold red) are applied during the initial FID loop and turned off afterwards. The readout gradient has constant magnitude (bold black) but it’s direction increments by an in-plane rotation of 2π/NSpkPerLoop = π/4 from one spoke to the next. The corresponding k-space encoding is shown in Fig. 1B. Each excitation starts with a straight radial spoke (bold black) which subsequently accumulates to a regular hexagon (black). The selfrefocusing hexagon trajectories of the first two excitations are illustrated in blue and green, respectively. Figure 1C illustrates the magnitude k-space dephasing and refocusing over time. Each excitation generates one coherence (during the initial FID loop) which subsequently refocus (during the later gradient echo loops). In a way, Looping Star can be understood as time-multiplexed, 3D radial gradient echo imaging. For 3D spatial encoding, the planar k-space trajectory needs to be rotated as illustrated in Fig. 1D FIGURE S2 Looping Star provides intrinsic coil sensitivity calibration. The single-channel PD-weighted FID images (top) are ideally suited for coil sensitivity calibration (bottom) as required for parallel imaging scan acceleration |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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