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Partial volume correction in arterial spin labeling using a Look-Locker sequence

Corresponding Author

Jan Petr

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Correspondence to: Jan Petr, Ph.D., HZDR, POB 51 01 19, 01314 Dresden, Germany. E-mail: [email protected]Search for more papers by this author

Georg Schramm,

Georg Schramm

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Frank Hofheinz,

Frank Hofheinz

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Jens Langner,

Jens Langner

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Jörg van den Hoff,

Jörg van den Hoff

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Jan Petr,

Corresponding Author

Jan Petr

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Correspondence to: Jan Petr, Ph.D., HZDR, POB 51 01 19, 01314 Dresden, Germany. E-mail: [email protected]Search for more papers by this author

Georg Schramm,

Georg Schramm

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Frank Hofheinz,

Frank Hofheinz

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Jens Langner,

Jens Langner

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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Jörg van den Hoff,

Jörg van den Hoff

PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

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First published: 27 December 2012

https://doi.org/10.1002/mrm.24601

Citations: 24

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Abstract

Purpose

Partial volume (PV) effects are caused by limited spatial resolution and significantly affect cerebral blood flow investigations with arterial spin labeling. Therefore, accurate PV correction (PVC) procedures are required. PVC is commonly based on PV maps obtained from segmented high-resolution T₁-weighted images. Segmentation of these images is error-prone, and it can be difficult to coregister these images accurately with the single-shot ASL images such as those created by echo-planar imaging (EPI). In this paper, an alternative method for PV map generation is proposed.

Methods

The Look-Locker EPI (LL-EPI) acquisition is used for analyzing the T₁-recovery curve and for subsequent PV map generation. The new method was evaluated in five healthy volunteers (mean age 30 ± 3.7 years).

Results

By applying a linear regression method for PVC, a 12% decrease in regression error was reached with the new method.

Conclusion

PV maps extraction from LL-EPI is a viable, possibly superior alternative to the standard approach based on segmentation of high-resolution T₁-weighted images. Magn Reson Med 70:1535–1543, 2013. © 2012 Wiley Periodicals, Inc.

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Volume70, Issue6

December 2013

Pages 1535-1543

Partial volume correction in arterial spin labeling using a Look-Locker sequence

Abstract

Purpose

Methods

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Conclusion

REFERENCES

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Partial volume correction in arterial spin labeling using a Look-Locker sequence

Abstract

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