Optimization of on-resonant magnetization transfer contrast in coronary vein MRI
Christian T. Stoeck
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
Search for more papers by this authorPeng Hu
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorDana C. Peters
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorKraig V. Kissinger
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorBeth Goddu
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorLois Goepfert
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorLong Ngo
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorWarren J. Manning
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorSebastian Kozerke
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
Search for more papers by this authorCorresponding Author
Reza Nezafat
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215===Search for more papers by this authorChristian T. Stoeck
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
Search for more papers by this authorPeng Hu
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorDana C. Peters
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorKraig V. Kissinger
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorBeth Goddu
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorLois Goepfert
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorLong Ngo
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorWarren J. Manning
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorSebastian Kozerke
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
Search for more papers by this authorCorresponding Author
Reza Nezafat
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215===Search for more papers by this authorAbstract
Magnetization transfer contrast has been used commonly for endogenous tissue contrast improvements in angiography, brain, body, and cardiac imaging. Both off-resonant and on-resonant RF pulses can be used to generate magnetization transfer based contrast. In this study, on-resonant magnetization transfer preparation using binomial pulses were optimized and compared with off-resonant magnetization transfer for imaging of coronary veins. Three parameters were studied with simulations and in vivo measurements: flip angle, pulse repetitions, and binomial pulse order. Subsequently, first or second order binomial on-resonant magnetization transfer pulses with eight repetitions of 720° and 240° flip angle were used for coronary vein MRI. Flip angles of 720° yielded contrast enhancement of 115% (P < 0.0006) for first order on-resonant and 95% (P < 0.0006) for off-resonant magnetization transfer. There was no statistically significance difference between off-resonant and on-resonant first order binomial Magnetization transfer at 720°. However, for off-resonance pulses, much more preparation time is needed when compared with the binomials but with considerably reduced specific absorption rate. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.
REFERENCES
- 1 Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989; 10: 135–144.
- 2 Henkelman RM, Stanisz GJ, Graham SJ. Magnetization transfer in MRI: a review. NMR Biomed 2001; 14: 57–64.
- 3 Pike GB, Hu BS, Glover GH, Enzmann DR. Magnetization transfer time-of-flight magnetic resonance angiography. Magn Reson Med 1992; 25: 372–379.
- 4 Edelman RR, Ahn SS, Chien D, Li W, Goldmann A, Mantello M, Kramer J, Kleefield J. Improved time-of-flight MR angiography of the brain with magnetization transfer contrast. Radiology 1992; 184: 395–399.
- 5 Atkinson D, Brant-Zawadzki M, Gillan G, Purdy D, Laub G. Improved MR angiography: magnetization transfer suppression with variable flip angle excitation and increased resolution. Radiology 1994; 190: 890–894.
- 6 Wolff SD, Balaban RS. Magnetization transfer imaging: practical aspects and clinical applications. Radiology 1994; 192: 593–599.
- 7 Graham SJ, Henkelman RM. Understanding pulsed magnetization transfer. J Magn Reson Imaging 1997; 7: 903–912.
- 8 Hua J, Hurst GC. Analysis of on- and off-resonance magnetization transfer techniques. J Magn Reson Imaging 1995; 5: 113–120.
- 9 Schneider E, Prost RW, Glover GH. Pulsed magnetization transfer versus continuous wave irradiation for tissue contrast enhancement. J Magn Reson Imaging 1993; 3: 417–423.
- 10 Hu BS, Conolly SM, Wright GA, Nishimura DG, Macovski A. Pulsed saturation transfer contrast. Magn Reson Med 1992; 26: 231–240.
- 11 Yeung HN, Aisen AM. Magnetization transfer contrast with periodic pulsed saturation. Radiology 1992; 183: 209–214.
- 12 Forster J, Schick F, Pfeffer M, Lutz O. Magnetization transfer by simple sequences of rectangular pulses. MAGMA 1995; 3: 83–93.
- 13 Henkelman RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993; 29: 759–766.
- 14 Morrison C, Henkelman RM. A model for magnetization transfer in tissues. Magn Reson Med 1995; 33: 475–482.
- 15 Quesson B, Thiaudiere E, Delalande C, Dousset V, Chateil JF, Canioni P. Magnetization transfer imaging in vivo of the rat brain at 4.7 T: interpretation using a binary spin-bath model with a superLorentzian lineshape. Magn Reson Med 1997; 38: 974–980.
- 16 Lin C, Bernstein MA, Gibbs GF, Huston J III. Reduction of RF power for magnetization transfer with optimized application of RF pulses in k-space. Magn Reson Med 2003; 50: 114–121.
- 17 Wang Y, Grist TM, Mistretta CA. Dispersion in magnetization transfer contrast at a given specific absorption rate due to variations of RF pulse parameters in the magnetization transfer preparation. Magn Reson Med 1997; 37: 957–962.
- 18 Nezafat R, Han Y, Peters DC, Herzka DA, Wylie JV, Goddu B, Kissinger KK, Yeon SB, Zimetbaum PJ, Manning WJ. Coronary magnetic resonance vein imaging: imaging contrast, sequence, and timing. Magn Reson Med 2007; 58: 1196–1206.
- 19
Schick F,
Forster J,
Pfeffer P,
Lutz O.
Pulsed magnetization transfer for imaging and spectroscopic applications on whole-body imagers.
MAGMA
1994;
2:
10.
10.1007/BF01753069 Google Scholar
- 20 Pike GB, Glover GH, Hu BS, Enzmann DR. Pulsed magnetization transfer spin-echo MR imaging. J Magn Reson Imaging 1993; 3: 531–539.
- 21
Davies NP,
Summers IR,
Vennart W.
Optimum setting of binomial pulses for magnetization transfer contrast.
J Magn Reson Imaging
2000;
11:
539–548.
10.1002/(SICI)1522-2586(200005)11:5<539::AID-JMRI10>3.0.CO;2-K CAS PubMed Web of Science® Google Scholar
- 22 Li D, Paschal CB, Haacke EM, Adler LP. Coronary arteries: three-dimensional MR imaging with fat saturation and magnetization transfer contrast. Radiology 1993; 187: 401–406.
- 23
Graham SJ,
Stanisz GJ,
Kecojevic A,
Bronskill MJ,
Henkelman RM.
Analysis of changes in MR properties of tissues after heat treatment.
Magn Reson Med
1999;
42:
1061–1071.
10.1002/(SICI)1522-2594(199912)42:6<1061::AID-MRM10>3.0.CO;2-T CAS PubMed Web of Science® Google Scholar
- 24 Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics 1982; 38: 963–974.
- 25 Littell RC, Milliken GA, Stroup WW, Wolfinger RD. SAS system for mixed models. Cary, North Carolina: SAS Institute, 1996. p 633.
- 26 Hu SB, Conolly MS, Wright AG, Nishimura GD, Macovski A. Pulsed saturation transfer contrast. Magn Reson Med 1992; 26: 231–240.
- 27 Pachot-Clouard M, Darrasse L. Optimization of T2-selective binomial pulses for magnetization transfer. Magn Reson Med 1995; 34: 462–469.
