Full Paper
Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI
Daniel P. Bulte,
Knut Drescher,
Peter Jezzard,
Corresponding Author
Daniel P. Bulte
FMRIB Centre, Department of Clinical Neurology, University of Oxford, United Kingdom
FMRIB Centre, John Radcliffe Hospital, Headington, Oxford OX3 9HN United Kingdom===Search for more papers by this authorKnut Drescher
FMRIB Centre, Department of Clinical Neurology, University of Oxford, United Kingdom
Department of Physics, University of Oxford, United Kingdom
Search for more papers by this authorPeter Jezzard
FMRIB Centre, Department of Clinical Neurology, University of Oxford, United Kingdom
Search for more papers by this authorDaniel P. Bulte,
Knut Drescher,
Peter Jezzard,
Corresponding Author
Daniel P. Bulte
FMRIB Centre, Department of Clinical Neurology, University of Oxford, United Kingdom
FMRIB Centre, John Radcliffe Hospital, Headington, Oxford OX3 9HN United Kingdom===Search for more papers by this authorKnut Drescher
FMRIB Centre, Department of Clinical Neurology, University of Oxford, United Kingdom
Department of Physics, University of Oxford, United Kingdom
Search for more papers by this authorPeter Jezzard
FMRIB Centre, Department of Clinical Neurology, University of Oxford, United Kingdom
Search for more papers by this authorAbstract
MRI may be used to measure fractional changes in cerebral oxygen metabolism via a metabolic model. One step commonly used in this measurement is calibration with image data acquired during hypercapnia, which is a state of increased CO2 content of the blood. In this study some commonly used hypercapnia-inducing stimuli were compared to assess their suitability for the calibration step. The following stimuli were investigated: (a) inspiration of a mixture of 4% CO2, 21% O2 and balance N2; (b) 30-s breath holding; and (c) inspiration of a mixture of 4% CO2 and 96% O2 (i.e., carbogen). Measurements of BOLD and cerebral blood flow made on nine subjects during the different hypercapnia-inducing stimuli showed that each stimulus leads to a different calibration of the model. We argue that of the aforementioned stimuli, inspiration of 4% CO2, 21% O2 and balance N2 should be preferred for the calibration as the other stimuli produce responses that violate assumptions of the metabolic model. Magn Reson Med 61:391–398, 2009. © 2009 Wiley-Liss, Inc.
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