Velocity-selective arterial spin labeling
Corresponding Author
Eric C. Wong
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Department of Psychiatry, University of California–San Diego, La Jolla, California, USA
UCSD Center for Functional MRI, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093-0677===Search for more papers by this authorMatthew Cronin
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorWen-Chau Wu
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorBen Inglis
Henry H. Wheeler, Jr., Brain Imaging Center, University of California–Berkeley, Berkeley, California, USA
Search for more papers by this authorLawrence R. Frank
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorThomas T. Liu
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorCorresponding Author
Eric C. Wong
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Department of Psychiatry, University of California–San Diego, La Jolla, California, USA
UCSD Center for Functional MRI, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093-0677===Search for more papers by this authorMatthew Cronin
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorWen-Chau Wu
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorBen Inglis
Henry H. Wheeler, Jr., Brain Imaging Center, University of California–Berkeley, Berkeley, California, USA
Search for more papers by this authorLawrence R. Frank
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorThomas T. Liu
Department of Radiology, University of California–San Diego, La Jolla, California, USA
Search for more papers by this authorAbstract
In pathologies in which slow or collateral flow conditions may exist, conventional arterial spin labeling (ASL) methods that apply magnetic tags based on the location of arterial spins may not provide robust measures of cerebral blood flow (CBF), as the transit delay for the delivery of blood to target tissues may far exceed the relaxation time of the tag. Here we describe current methods for ASL with velocity-selective (VS) tags (termed VSASL) that do not require spatial selectivity and can thus provide quantitative measures of CBF under slow and collateral flow conditions. The implementation of a robust multislice VSASL technique is described in detail, and data obtained with this technique are compared with those obtained with conventional pulsed ASL (PASL). The technical considerations described here include the design of VS pulses, background suppression, anisotropy with respect to velocity-encoding directions, and CBF quantitation issues. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc.
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