Volume 34, Issue 4 pp. 628-631

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Validation of ¹⁹f-magnetic resonance determination of myocardial blood volume

Gerald A. Rottman M.D.,

Corresponding Author

Gerald A. Rottman M.D.

Departments of Radiology, Johns Hopkins Medical Institutes, Baltimore, Maryland.

6905 Park Heights Avenue, Baltimore, MD 21215===Search for more papers by this author

Robert M. Judd,

Robert M. Judd

Departments of Radiology, Johns Hopkins Medical Institutes, Baltimore, Maryland.

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Frank C. P. Yin,

Frank C. P. Yin

Departments of Radiology and Medicine, Johns Hopkins Medical Institutes, Baltimore, Maryland.

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Gerald A. Rottman M.D.,

Corresponding Author

Gerald A. Rottman M.D.

Departments of Radiology, Johns Hopkins Medical Institutes, Baltimore, Maryland.

6905 Park Heights Avenue, Baltimore, MD 21215===Search for more papers by this author

Robert M. Judd,

Robert M. Judd

Departments of Radiology, Johns Hopkins Medical Institutes, Baltimore, Maryland.

Search for more papers by this author

Frank C. P. Yin,

Frank C. P. Yin

Departments of Radiology and Medicine, Johns Hopkins Medical Institutes, Baltimore, Maryland.

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First published: October 1995

https://doi.org/10.1002/mrm.1910340421

Citations: 8

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Abstract

The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of ¹⁹F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and ¹²⁵I-albumin. Measurement of myocardial vascular volume by ¹⁹F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.

References

1 R. M. Judd, G. A. Rottman, J. R. Forder, F. C. P. Yin, S. J. Blackband, Feasibility of ₁₉F imaging of perfluorochemical emulsions to measure myocardial vascular volume. Magn. Reson. Med. 28, 129–136 (1992).
10.1002/mrm.1910280113
CAS PubMed Web of Science® Google Scholar
2 K. L. Meyer, P. M. Joseph, B. Mukherji, V. A. Livolsi, R. Lin, Measurement of vascular volume in experimental rat tumors by ₁₉F magnetic resonance imaging. Invest. Radiol. 28, 710–719 (1993).
10.1097/00004424-199308000-00012
CAS PubMed Web of Science® Google Scholar
3 C. Thomas, C. Counsell, P. Wood, G. E. Adams, Use of fluorine-19 nuclear magnetic resonance spectroscopy and hydralazine for measuring dynamic changes in blood perfu-sion volume in tumors in mice. J. Nutl. Cancer Inst. 84, 174–180 (1992).
10.1093/jnci/84.3.174
CAS PubMed Web of Science® Google Scholar
4 T. L. Ceckler, S. L. Gibson, R. Hilf, R. G. Bryant, In situ assessment of tumor vascularity using fluorine NMR imag-ing. Magn. Reson. Med. 13, 416–433 (1990).
10.1002/mrm.1910130309
CAS PubMed Web of Science® Google Scholar
5 R. P. Mason, F. M. H. Jeffrey, C. R. Malloy, E. E. Babcock, P. P. Antich, A noninvasive assessment of myocardial oxy-gen tension: ₁₉F NMR spectroscopy of sequestered perfluo-rocarbon emulsion. Magn. Reson. Med. 27, 310–317 (1992).
10.1002/mrm.1910270210
CAS PubMed Web of Science® Google Scholar
6 J. Taylor, C. Deutsch, ₁₉F nuclear magnetic resonance: mea-surements of [O,] and pH in biological systems. Biophys. J. 53, 227–233 (1988).
10.1016/S0006-3495(88)83084-4
CAS PubMed Web of Science® Google Scholar
7 R. P. Mason, R. L. Nunnally, P. P. Antich, Tissue oxygen-ation: a novel determination using ₁₉F surface coil NMR spectroscopy of sequestered perfluorocarbon emulsion. Magn. Reson. Med. 18, 71–79 (1991).
10.1002/mrm.1910180109
CAS PubMed Web of Science® Google Scholar
8 C. Lai, S. J. Stair, H. Miziorko, J. S. Hyde, Effect of oxygen and the lipid spin label TEMPO-laurate on fluorine-19 and proton relaxation rates of the perfluorochemical blood sub-stitute, FC-43 emulsion. J. Magn. Reson. 57, 447–452 (1984).
10.1016/0022-2364(84)90259-2
CAS Web of Science® Google Scholar
9 P. Parhami, B. M. Fung, Fluorine-19 relaxation study of perfluoro chemicals as oxygen carriers. J. Phys. Chem. 87, 1928–1931 (1983).
10.1021/j100234a020
CAS Web of Science® Google Scholar
10 B. A. Berkowitz, C. R. Wilson, D. L. Hatchell, R. E. London, Quantitative determination of the partial oxygen pressure in the vitrectomized rabbit eye in vivo using ₁₉F NMR. Magn. Reson. Med. 21, 233–241 (1991).
10.1002/mrm.1910210208
Google Scholar
11 D. Eidelberg, G. Johnson, D. Barnes, P. G. Tofts, D. Delpy, D. Plummer, W. I. McDonald, ₁₉F NMR imaging of blood oxy-genation in the brain. Magn. Reson. Med. 6, 344–352 (1988).
10.1002/mrm.1910060312
CAS PubMed Web of Science® Google Scholar
12 J. J. Neil, J. J. H. Ackerman, Detection of pseudodiffusion in rat brain following blood substitution with perfluorocarbon. J. Mugn. Reson. 97, 194–201 (1992).
10.1016/0022-2364(92)90249-7
CAS Web of Science® Google Scholar
13 N. Baldwin, Y. Wang, I. Karalis, T. C. Ng, ₁₉F MRS measure-ment of tumor blood volume: corroboration by radioisotope labeled (lZ5I) protein and correlation with tumor mass, in “Proc., SMR, 2nd Annual Meeting, 1994,” p. 1346.
Google Scholar
14 A. V. Ratner, H. E. Muller, B. Bradley-Simpson, D. E. John-son, R. E. Hurd, C. Sotak, S. W. Young, Detection of tumors with ₁₉F magnetic resonance imaging. Invest. Radiol. 23, 361–364 (1988).
10.1097/00004424-198805000-00006
CAS PubMed Web of Science® Google Scholar
15 A. V. Ratner, R. Hurd, H. H. Muller, B. Bradley-Simpson, W. Pitts, D. Shibata, C. Sotak, S. W. Young, ₁₉F magnetic reso-nance imaging of the reticuloendothelial system. Magn. Re-son. Med. 5, 548–554 (1987).
10.1002/mrm.1910050605
CAS PubMed Web of Science® Google Scholar
16 C. Crone, D. G. Levitt, Capillary permeability to small sol-utes. in “Handbook of Physiology” ( E. M. Renkin, C. C. Michel, S. R. Geiger, Eds.), Vol. IV, pp. 411–439, American Physiological Society: Section 2, Bethesda, 1984
Google Scholar
17 R. M. Judd, J. R. Resar, F. C. P. Yin, Rapid measurements of diastolic intramyocardial vascular volume. Am. J. Physiol. 265, H1038–H1047 (1993).
CAS PubMed Web of Science® Google Scholar
18 R. M. Judd, B. I. Levy, Effects of barium-induced cardiac contraction on large-and small-vessel intramyocardial blood volume. Circ. Res. 68, 217–225 (1991).
10.1161/01.RES.68.1.217
CAS PubMed Web of Science® Google Scholar
19 P. Eliasen, O. Amtorp, E. Tondevold, S. Haunso, Regional blood flow, microvascular blood content and tissue hemat-ocrit in canine myocardium. Cardiovasc. Res. 16, 593–598 (1982).
10.1093/cvr/16.10.593
CAS PubMed Web of Science® Google Scholar
20 N.-H. Areskog, G. Arturson, G. Grotte, Studies on heart lymph: I. Kinetics of 1311-albumin in dog heart-lung prepa-rations. Acta Physiol. Scand. 62, 209–217 (1964).
10.1111/j.1748-1716.1964.tb03968.x
CAS PubMed Web of Science® Google Scholar

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Volume34, Issue4

October 1995

Pages 628-631

Validation of ¹⁹f-magnetic resonance determination of myocardial blood volume

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Validation of 19f-magnetic resonance determination of myocardial blood volume

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Validation of ¹⁹f-magnetic resonance determination of myocardial blood volume