Volume 52, Issue S1 pp. 19-27
Research Article

The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern chinese populations

Dongsheng Huang

Dongsheng Huang

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

Guangzhou Chest Hospital, Guangzhou, P.R. China

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Fuman Qiu

Fuman Qiu

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Lei Yang

Lei Yang

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Yinyan Li

Yinyan Li

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Mei Cheng

Mei Cheng

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Hui Wang

Hui Wang

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Guanpei Ma

Guanpei Ma

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Yunnan Wang

Yunnan Wang

Guangzhou Chest Hospital, Guangzhou, P.R. China

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Min Hu

Min Hu

Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, P.R. China

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Weidong Ji

Weidong Ji

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

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Yifeng Zhou

Yifeng Zhou

Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, P.R. China

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Jiachun Lu

Corresponding Author

Jiachun Lu

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, P.R. China

The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou 510182, P.R. China.Search for more papers by this author
First published: 12 June 2012
Citations: 10
D. Huang, F. Qiu, and L. Yang contributed equally to this work.
The authors declare no competing interests.

Abstract

The WW domain-containing oxidoreductase (WWOX) gene is an identified tumor suppressor gene, of which several single nucleotide polymorphisms have been reported to contribute to cancer susceptibility. We hypothesized that genetic variations in WWOX are associated with lung cancer risk. In two independent case–control studies conducted in southern and eastern Chinese, we genotyped five tagSNPs of WWOX gene (rs10220974C > T, rs3764340C > G, rs12918952G > A, rs383362G > T, and rs12828G > A) in 1,559 lung cancer cases and 1,679 controls. Logistic regression analysis showed that two tagSNPs (rs3764340C > G; rs383362G > T) were significantly associated with lung cancer risk in dominant model (rs3764340C > G, GC/GG vs. CC: adjust OR = 1.35, 95% CI = 1.11–1.65; rs383362G > T, TG + TT vs. GG: adjust OR = 1.33, 95% CI = 1.14–1.55). The haplotype analysis further shown that the haplotype “G-T” was associated with the highest increased risk of lung cancer (OR = 2.20; 95% CI = 1.43–3.37). After combined these two loci, the number of the risk genotypes was associated with increased cancer risk in a dose–response manner (Ptrend = 3.16 × 10−6). In addition, a gene-based association analysis by using VEGAS software suggested the WWOX as a susceptible gene for lung cancer (P = 0.009). However, for rs10220974C > T, rs12918952G > A, and rs12828G > A, no significant association was observed for lung cancer risk. Taken together, our data suggested that genetic variants in WWOX may be genetic biomarkers for susceptibility to lung cancer. Copyright © 2012 Wiley Periodicals, Inc.

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