Backbone-Thermoresponsive Hyperbranched Polyglycerol by Random Copolymerization of Glycidol and 3-Methyl-3-(hydroxymethyl)oxetane
Yumin Xia
College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China
Search for more papers by this authorCorresponding Author
Yimin Wang
College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China
Yimin Wang, College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China Fax: (+86)-21-67792844.
Xinyuan Zhu, School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Fax: (+86)-21-34205722.
Search for more papers by this authorYanping Wang
College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China
Search for more papers by this authorDali Wang
Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorHongping Deng
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorYuanyuan Zhuang
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorDeyue Yan
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorBangshang Zhu
Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorCorresponding Author
Xinyuan Zhu
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Yimin Wang, College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China Fax: (+86)-21-67792844.
Xinyuan Zhu, School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Fax: (+86)-21-34205722.
Search for more papers by this authorYumin Xia
College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China
Search for more papers by this authorCorresponding Author
Yimin Wang
College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China
Yimin Wang, College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China Fax: (+86)-21-67792844.
Xinyuan Zhu, School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Fax: (+86)-21-34205722.
Search for more papers by this authorYanping Wang
College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China
Search for more papers by this authorDali Wang
Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorHongping Deng
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorYuanyuan Zhuang
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorDeyue Yan
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorBangshang Zhu
Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Search for more papers by this authorCorresponding Author
Xinyuan Zhu
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Yimin Wang, College of Materials Science and Engineering, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Songjiang, Shanghai 201620, P.R. China Fax: (+86)-21-67792844.
Xinyuan Zhu, School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China Fax: (+86)-21-34205722.
Search for more papers by this authorAbstract
The hyperbranched polyglycerol analog, hyperbranched poly[glycerol-co-3-methyl-3-(hydroxymethyl)oxetane] [HP(G-co-M)], was synthesized in one-step by random copolymerization of glycidol and 3-methyl-3-(hydroxymethyl)oxetane (MHO). The obtained polymer exhibited a thermoresponsive behavior in an aqueous solution, and the corresponding lower critical solution temperature (LCST) could be readily adjusted by changing the feed ratio of glycidol to MHO. The MTT assay against COS-7 cells demonstrated that HP(G-co-M) had low cytotoxicity. Moreover, the existence of numerous hydroxyl terminals of HP(G-co-M) facilitated their further modification and functionalization. All of these characteristics suggest that this novel backbone-thermoresponsive hyperbranched polyglycerol is a promising functional material for biomedical applications.
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