Original Report

Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study

Alberto Deganello PhD

orcid.org/0000-0003-1008-7333

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Alberto Paderno MD,

Corresponding Author

Alberto Paderno MD

[email protected]

orcid.org/0000-0002-1621-2142

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

Send correspondence to Alberto Paderno, MD, Department of Otorhinolaryngology – Head and Neck Surgery, Spedali Civili of Brescia, Piazzale Spedali Civili 1, University of Brescia, 25123 Brescia, Italy. E-mail: [email protected]

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Riccardo Morello MD,

Riccardo Morello MD

orcid.org/0000-0003-4460-997X

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Surgical Specialties, Cremona, Italy

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Milena Fior MD,

Milena Fior MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Giulia Berretti MD,

Giulia Berretti MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Francesca Del Bon MD,

Francesca Del Bon MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Marco Alparone MD,

Marco Alparone MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Elena Bardellini MD,

Elena Bardellini MD

Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy

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Alessandra Majorana MD,

Alessandra Majorana MD

Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy

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Piero Nicolai MD,

Piero Nicolai MD

Section of Otorhinolaryngology–Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, Italy

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Alberto Deganello PhD,

Alberto Deganello PhD

orcid.org/0000-0003-1008-7333

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Alberto Paderno MD,

Corresponding Author

Alberto Paderno MD

[email protected]

orcid.org/0000-0002-1621-2142

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Riccardo Morello MD,

Riccardo Morello MD

orcid.org/0000-0003-4460-997X

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Surgical Specialties, Cremona, Italy

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Milena Fior MD,

Milena Fior MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Giulia Berretti MD,

Giulia Berretti MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Francesca Del Bon MD,

Francesca Del Bon MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Marco Alparone MD,

Marco Alparone MD

Unit of Otorhinolaryngology–Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

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Elena Bardellini MD,

Elena Bardellini MD

Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy

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Alessandra Majorana MD,

Alessandra Majorana MD

Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy

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Piero Nicolai MD,

Piero Nicolai MD

Section of Otorhinolaryngology–Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, Italy

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First published: 14 August 2020

https://doi.org/10.1002/lary.29035

Citations: 10

Disclosure: The authors have no funding or conflicts of interest to declare.

Editor’s Note: This Manuscript was accepted for publication on July 30, 2020.

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Abstract

Objective

Oral lichen planus (OLP) is a chronic mucocutaneous immune-mediated disease affecting 1% to 4% of the worldwide population. Development of malignant lesions is reported but only affects a minority of patients. The aim of our study was to assess the diagnostic potential of narrow band imaging (NBI) in OLP patients; focusing on the identification of high-grade dysplasia/carcinoma in newly developed lesions.

Methods

Prospective evaluation of 56 patients with histopathologic diagnosis of OLP and presenting newly developed lesions not responding to medical treatment. All lesions were assessed by high-definition (HD) white light (WL) and HD-NBI endoscopy. All patients underwent biopsy regardless of the appearance at HD-WL and HD-NBI. Histology was defined as “positive” in case of high-grade dysplasia or carcinoma.

Results

Five lesions (9%) were diagnosed as high-grade dysplasia/carcinoma. In this setting, overall diagnostic potential of HD-NBI was optimal, with a sensitivity of 100% (95% CI, 48–100), specificity of 96% (95% CI, 86–99), negative predictive value of 100% (95% CI, not calculable), positive predictive value of 71% (95% CI, 39–91), and accuracy of 96% (95% CI, 88–100).

Conclusions

Despite the diffuse inflammatory pattern derived from OLP, NBI improved the diagnostic accuracy and the capability to detect high-grade dysplasia/carcinoma.

Level of Evidence

4 Laryngoscope, 131:E1156–E1161, 2021

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Volume131, Issue4

April 2021

Pages E1156-E1161

Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study

Abstract

Objective

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

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Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study

Abstract

Objective

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

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