Volume 131, Issue 4 pp. 806-812

Original Report

Familial Aggregation of Head and Neck Cancer in Taiwan

Paula Francezca Padua MD,

Paula Francezca Padua MD

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou branch, Taoyuan, Taiwan

These authors contributed equally to this work.

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Chia-Chen Lin MD,

Chia-Chen Lin MD

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou branch, Taoyuan, Taiwan

These authors contributed equally to this work.

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Hui-Tzu Chien PhD,

Hui-Tzu Chien PhD

Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan

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Chi-Kuan Young MD,

Chi-Kuan Young MD

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Keelung branch, Keelung, Taiwan

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Chang-Fu Kuo MD, PhD,

Chang-Fu Kuo MD, PhD

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, UK

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Lai-Chu See PhD,

Lai-Chu See PhD

Department of Public Health, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

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Shue-Fen Luo MD,

Shue-Fen Luo MD

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Lu-Hsiang Huang BS,

Lu-Hsiang Huang BS

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Shiang-Fu Huang MD, PhD,

Corresponding Author

Shiang-Fu Huang MD, PhD

[email protected]

orcid.org/0000-0003-3582-9938

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou branch, Taoyuan, Taiwan

Department of Public Health, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan

Send correspondence to Shiang-Fu Huang, MD, PhD, Department of Otolaryngology, Chang Gung Memorial Hospital at No. 5 Fu-Shin Street, Kwei-Shan, Taoyuan, Taiwan, Republic of China. E-mail: [email protected]

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Paula Francezca Padua MD,

Paula Francezca Padua MD

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou branch, Taoyuan, Taiwan

These authors contributed equally to this work.

Search for more papers by this author

Chia-Chen Lin MD,

Chia-Chen Lin MD

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou branch, Taoyuan, Taiwan

These authors contributed equally to this work.

Search for more papers by this author

Hui-Tzu Chien PhD,

Hui-Tzu Chien PhD

Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan

Search for more papers by this author

Chi-Kuan Young MD,

Chi-Kuan Young MD

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Keelung branch, Keelung, Taiwan

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Chang-Fu Kuo MD, PhD,

Chang-Fu Kuo MD, PhD

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, UK

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Lai-Chu See PhD,

Lai-Chu See PhD

Department of Public Health, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

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Shue-Fen Luo MD,

Shue-Fen Luo MD

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Lu-Hsiang Huang BS,

Lu-Hsiang Huang BS

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Shiang-Fu Huang MD, PhD,

Corresponding Author

Shiang-Fu Huang MD, PhD

[email protected]

orcid.org/0000-0003-3582-9938

Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou branch, Taoyuan, Taiwan

Department of Public Health, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan

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First published: 21 August 2020

https://doi.org/10.1002/lary.28992

Citations: 3

Editor's Note: This Manuscript was accepted for publication on July 13, 2020.

Supported by Chang Gung Memorial Hospital, grants CMRPG3H0793, CMRPG3J0591, CMRPG3J0592, and CMRPB53; the Ministry of Science and Technology, Executive Yuan, Taiwan, ROC; the Health and Welfare Surcharge on Tobacco Products, grants MOST106-2314-B-182-025-MY3 and MOST109-2314-B-182-015-; and the Ministry of Health and Welfare (MOHW), Executive Yuan, Taiwan, ROC, grant MOHW109-TDU-B-212-134016. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives

Head and neck cancer (HNC) incidence has been increasing worldwide. We investigated the familial aggregation of developing HNC if a first-degree relative (FDR) is affected in a large database.

Methods

This retrospective study utilized Taiwan National Health Insurance Database to assemble a cohort of all registered beneficiaries from 1997 to 2013 and identified diagnosed HNC patients with affected FDRs.

Results

Of the 55,916 individuals diagnosed with HNC, 566 (1.01%) had affected FDRs. There were 525 (0.56%) males and 41 (0.05%) females. Age of onset of HNC was found to be earlier for those with an affected FDR at the fourth decade of life compared to the general population. The adjusted relative risks (RRs) of an individual with an affected FDR to develop HNC is 2.04 (95% confidence interval [CI], 1.85–2.26): 2.07 (95% CI, 1.88–2.29) if the affected relative was male, and 1.74 (95% CI, 1.31–2.30) if the affected relative was female. The greatest risk to develop HNC is if the affected individual is a twin with adjusted RR 33.04 (95% CI, 12.89–84.69). This is followed by an affected sibling at RR (95% CI) 3.46 (1.68–7.13), offspring at RR 2.28 (95% CI, 1.94–2.69), and parent at RR 1.66 (95% CI, 1.48–1.87).

Conclusion

Familial tendency of HNC proves the probable contribution of genetic factors to develop cancer. In areca quid endemic region, there is a high likelihood that both environmental and genetic factors work in synergy to develop HNC.

Level of Evidence

3 Laryngoscope, 131:806–812, 2021

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Volume131, Issue4

April 2021

Pages 806-812

Familial Aggregation of Head and Neck Cancer in Taiwan

Abstract

Objectives

Methods

Results

Conclusion

Level of Evidence

BIBLOGRAPHY

Citing Literature

References

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Familial Aggregation of Head and Neck Cancer in Taiwan

Abstract

Objectives

Methods

Results

Conclusion

Level of Evidence

BIBLOGRAPHY

Citing Literature

References

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