Volume 131, Issue 4 pp. E1287-E1295

Original Report

Low-Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Correction(s) for this article

Yasunori Abe MD,

Yasunori Abe MD

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

Depertment of Otolaryngology, Ehime University Graduate School of Medicine, Ehime, Japan

These authors contributed equally to this work.

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Kensuke Toyama MD, PhD,

Corresponding Author

Kensuke Toyama MD, PhD

[email protected]

orcid.org/0000-0002-3959-4737

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

JA Ehime Kouseiren Checkup Center, Ehime, Japan

These authors contributed equally to this work.

Send correspondence to Kensuke Toyama, MD, PhD, Department of Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa 454, Toon city, Ehime, Japan, 791-0295. E-mail: [email protected]

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Masaya Kazurayama MD,

Masaya Kazurayama MD

JA Ehime Kouseiren Checkup Center, Ehime, Japan

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Shinji Tanaka MD, PhD,

Shinji Tanaka MD, PhD

JA Ehime Kouseiren Checkup Center, Ehime, Japan

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Masamitsu Yamaizumi MD,

Masamitsu Yamaizumi MD

JA Ehime Kouseiren Checkup Center, Ehime, Japan

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Megumi Ueno MD,

Megumi Ueno MD

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

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Joshua M. Spin MD, PhD,

Joshua M. Spin MD, PhD

VA Palo Alto Health Care System, Palo Alto, California, U.S.A.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, U.S.A.

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Naohito Hato MD, PhD,

Naohito Hato MD, PhD

Depertment of Otolaryngology, Ehime University Graduate School of Medicine, Ehime, Japan

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Masaki Mogi MD, PhD,

Masaki Mogi MD, PhD

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

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Yasunori Abe MD,

Yasunori Abe MD

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

Depertment of Otolaryngology, Ehime University Graduate School of Medicine, Ehime, Japan

These authors contributed equally to this work.

Search for more papers by this author

Kensuke Toyama MD, PhD,

Corresponding Author

Kensuke Toyama MD, PhD

[email protected]

orcid.org/0000-0002-3959-4737

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

JA Ehime Kouseiren Checkup Center, Ehime, Japan

These authors contributed equally to this work.

Send correspondence to Kensuke Toyama, MD, PhD, Department of Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa 454, Toon city, Ehime, Japan, 791-0295. E-mail: [email protected]

Search for more papers by this author

Masaya Kazurayama MD,

Masaya Kazurayama MD

JA Ehime Kouseiren Checkup Center, Ehime, Japan

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Shinji Tanaka MD, PhD,

Shinji Tanaka MD, PhD

JA Ehime Kouseiren Checkup Center, Ehime, Japan

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Masamitsu Yamaizumi MD,

Masamitsu Yamaizumi MD

JA Ehime Kouseiren Checkup Center, Ehime, Japan

Search for more papers by this author

Megumi Ueno MD,

Megumi Ueno MD

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

Search for more papers by this author

Joshua M. Spin MD, PhD,

Joshua M. Spin MD, PhD

VA Palo Alto Health Care System, Palo Alto, California, U.S.A.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, U.S.A.

Search for more papers by this author

Naohito Hato MD, PhD,

Naohito Hato MD, PhD

Depertment of Otolaryngology, Ehime University Graduate School of Medicine, Ehime, Japan

Search for more papers by this author

Masaki Mogi MD, PhD,

Masaki Mogi MD, PhD

Department of Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan

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First published: 24 August 2020

https://doi.org/10.1002/lary.28970

Citations: 3

Editor's Note: This Manuscript was accepted for publication on July 07, 2020.

This study was partially supported by a Grant-in-Aid for Young Scientists (Start-up; JSPS KAKENHI grant number: JP19K21316). The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objective

Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor for permanent hearing impairment. This implies that abnormal platelets might contribute to long-term hearing loss. This study investigated the role of platelets in the development of hearing impairment over a 5-year period.

Methods

This study was a retrospective cohort study and consisted of a population-based survey, which was performed for 1,897 participants in 2014 to 2019. To evaluate the effect of platelet level on hearing ability, the subjects were divided into two groups: a high-normal platelet group (25 ∼ 40 × 10⁴ cells/μL) and a low-normal platelet group (15 ∼ 25 × 10⁴ cells/μL). Subjects were defined as having hearing impairment when pure tone audiometry was over 25 dB HL in either ear (tested in 2017 and 2019). Incidence of hearing impairment was analyzed.

Results

Incidence of hearing impairment at low frequencies was significantly higher in the low-normal platelet group than in the high-normal group year over year. Low-normal platelet count associated with low-frequency hearing impairment (LFHI) incidence (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.15–4.76). In the low-normal platelet group, subjects whose counts declined from baseline developed more LFHI than those whose counts increased over time. Further, decreasing platelets appeared to be an independent risk factor contributing to the incidence of LFHI (OR, 2.10; 95%CI, 1.09–4.06) in the low-normal platelet group.

Conclusion

Both a low-normal platelet and a declining platelet count were independently associated with the incidence of LFHI.

Level of Evidence

3 Laryngoscope, 131:E1287–E1295, 2021

Supporting Information

Filename	Description
lary28970-sup-0001-Tables.docxWord 2007 document , 55.6 KB	Table S1. Prevalence of hearing impairment in the participants with pure tone audiometry data and platelet numbers in 2014 (n = 7552). Table S2. Characteristics and clinical parameters. Table S3. Characteristics and clinical parameters in subjects with high-normal and low-normal platelet levels (Propensity score matched sample)
lary28970-sup-0002-FigureS1.pdfPDF document, 51.1 KB	Fig. S1. Histogram of platelet count distribution (2014). Distribution of platelet counts was evaluated in participants with available pure tone audiometry data and platelet numbers from their 2014 checkup (n = 7552).
lary28970-sup-0003-FigureS2.pdfPDF document, 71.7 KB	Fig. S2. Incidence of hearing impairment in subjects with high-normal and low-normal platelet levels (Propensity score matched sample). Incidence levels of hearing impairment over time at 3 years (2017) and 5 years of follow up (2019) at (A) low frequency, and (B) high frequency pure tone analysis are shown, respectively. After adjustment for propensity score, χ2-test was performed in each year between low and high-platelet group at both frequencies. A two-way repeated measure analysis of variance was also used to evaluate simultaneously the effect of grouping for platelet counts on hearing impairment. Numbers described on each bar are “number of incidents/ total numbers”.
lary28970-sup-0004-FigureS3.pdfPDF document, 164.5 KB	Fig. S3. Platelet change in the high−/low-normal platelet group. The line graphs indicate platelet counts at baseline (2014), 3 years of follow up (2017) and 5 years of follow up between platelet decreasing and increasing groups in (A) high-normal and (B) low-normal platelet group. The bar graphs indicate the changes of platelet count over the 5 years in the (C) high-normal and (D) low-normal platelet group.

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Volume131, Issue4

April 2021

Pages E1287-E1295

Low-Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Correction(s) for this article

Erratum

Abstract

Objective

Methods

Results

Conclusion

Level of Evidence

Supporting Information

BIBLIOGRAPHY

Citing Literature

References

Information

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Low-Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Correction(s) for this article

Erratum

Abstract

Objective

Methods

Results

Conclusion

Level of Evidence

Supporting Information

BIBLIOGRAPHY

Citing Literature

References

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